Sarcopenia and associated factors among older adults at high risk of dementia

Detalhes bibliográficos
Autor(a) principal: de Sousa, D.
Data de Publicação: 2024
Outros Autores: Costa, A.R., Vicente, M., Cruz, V.T., Padrão, Patrícia
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/162462
Resumo: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Sarcopenia and dementia share pathophysiological pathways and risk factors, including advanced age, physical inactivity, unhealthy diet, smoking and diabetes. Older adults at high risk of dementia may face increased susceptibility to sarcopenia, which can also exacerbate cognitive decline. Thus, this study aims to estimate the frequency of sarcopenia and its associated factors within this vulnerable population.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This cross-sectional analysis includes data from a subset of older adults (65 years of age) enrolled in the MIND-Matosinhos randomized controlled trial, a community-based cognitive decline prevention program. Per the European Working Group on Sarcopenia in Older People, probable sarcopenia is defined as low muscle strength (handgrip strength &lt;16 kg for women and &lt;27 kg for men). Sociodemographic, lifestyle and health-related data were collected via structured questionnaires. To assess factors associated with sarcopenia, odds ratios (OR) and respective confidence intervals (95% CI) were estimated using logistic regression.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 157 participants (58.6% female), with a median age of 73 years (range: 65 to 85 years), were included. The overall prevalence of sarcopenia was 21.7% (n=34). After adjusting for sex, age and education, inadequate adherence to Mediterranean Diet (MD) (OR=10.90; 95% CI:1.41-84.52), current smoking status (OR=5.06; 95% CI:1.06-24.18) and poorer self-perceived health (OR=2.74; 95% CI:1.03-7.28) were positively associated with sarcopenia. No other statistically significant associations were found.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The observed sarcopenia frequency underscores the need for enhanced screening and management of this condition in community settings and among those at dementia risk. Inadequate adherence to MD, smoking and poor self-perceived health, seem to be associated with sarcopenia in older adults at high risk of dementia. Sarcopenia prevention should involve a holistic approach to promoting a healthy lifestyle.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>Sarcopenia was observed in 21.7% of older adults at high risk of dementia, indicating a significant burden on this vulnerable population.</jats:p> <jats:p>Inadequate adherence to the Mediterranean diet, smoking and poor self-perceived health were associated with sarcopenia.</jats:p> </jats:sec>
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spelling Sarcopenia and associated factors among older adults at high risk of dementiaCiências da Saúde, Ciências médicas e da saúdeHealth sciences, Medical and Health sciences<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Sarcopenia and dementia share pathophysiological pathways and risk factors, including advanced age, physical inactivity, unhealthy diet, smoking and diabetes. Older adults at high risk of dementia may face increased susceptibility to sarcopenia, which can also exacerbate cognitive decline. Thus, this study aims to estimate the frequency of sarcopenia and its associated factors within this vulnerable population.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This cross-sectional analysis includes data from a subset of older adults (65 years of age) enrolled in the MIND-Matosinhos randomized controlled trial, a community-based cognitive decline prevention program. Per the European Working Group on Sarcopenia in Older People, probable sarcopenia is defined as low muscle strength (handgrip strength &lt;16 kg for women and &lt;27 kg for men). Sociodemographic, lifestyle and health-related data were collected via structured questionnaires. To assess factors associated with sarcopenia, odds ratios (OR) and respective confidence intervals (95% CI) were estimated using logistic regression.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 157 participants (58.6% female), with a median age of 73 years (range: 65 to 85 years), were included. The overall prevalence of sarcopenia was 21.7% (n=34). After adjusting for sex, age and education, inadequate adherence to Mediterranean Diet (MD) (OR=10.90; 95% CI:1.41-84.52), current smoking status (OR=5.06; 95% CI:1.06-24.18) and poorer self-perceived health (OR=2.74; 95% CI:1.03-7.28) were positively associated with sarcopenia. No other statistically significant associations were found.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The observed sarcopenia frequency underscores the need for enhanced screening and management of this condition in community settings and among those at dementia risk. Inadequate adherence to MD, smoking and poor self-perceived health, seem to be associated with sarcopenia in older adults at high risk of dementia. Sarcopenia prevention should involve a holistic approach to promoting a healthy lifestyle.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>Sarcopenia was observed in 21.7% of older adults at high risk of dementia, indicating a significant burden on this vulnerable population.</jats:p> <jats:p>Inadequate adherence to the Mediterranean diet, smoking and poor self-perceived health were associated with sarcopenia.</jats:p> </jats:sec>20242024-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/10216/162462eng10.1093/eurpub/ckae144.1346de Sousa, D.Costa, A.R.Vicente, M.Cruz, V.T.Padrão, Patríciainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-08T01:22:46Zoai:repositorio-aberto.up.pt:10216/162462Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-08T01:22:46Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sarcopenia and associated factors among older adults at high risk of dementia
title Sarcopenia and associated factors among older adults at high risk of dementia
spellingShingle Sarcopenia and associated factors among older adults at high risk of dementia
de Sousa, D.
Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
title_short Sarcopenia and associated factors among older adults at high risk of dementia
title_full Sarcopenia and associated factors among older adults at high risk of dementia
title_fullStr Sarcopenia and associated factors among older adults at high risk of dementia
title_full_unstemmed Sarcopenia and associated factors among older adults at high risk of dementia
title_sort Sarcopenia and associated factors among older adults at high risk of dementia
author de Sousa, D.
author_facet de Sousa, D.
Costa, A.R.
Vicente, M.
Cruz, V.T.
Padrão, Patrícia
author_role author
author2 Costa, A.R.
Vicente, M.
Cruz, V.T.
Padrão, Patrícia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv de Sousa, D.
Costa, A.R.
Vicente, M.
Cruz, V.T.
Padrão, Patrícia
dc.subject.por.fl_str_mv Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
topic Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
description <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Sarcopenia and dementia share pathophysiological pathways and risk factors, including advanced age, physical inactivity, unhealthy diet, smoking and diabetes. Older adults at high risk of dementia may face increased susceptibility to sarcopenia, which can also exacerbate cognitive decline. Thus, this study aims to estimate the frequency of sarcopenia and its associated factors within this vulnerable population.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This cross-sectional analysis includes data from a subset of older adults (65 years of age) enrolled in the MIND-Matosinhos randomized controlled trial, a community-based cognitive decline prevention program. Per the European Working Group on Sarcopenia in Older People, probable sarcopenia is defined as low muscle strength (handgrip strength &lt;16 kg for women and &lt;27 kg for men). Sociodemographic, lifestyle and health-related data were collected via structured questionnaires. To assess factors associated with sarcopenia, odds ratios (OR) and respective confidence intervals (95% CI) were estimated using logistic regression.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 157 participants (58.6% female), with a median age of 73 years (range: 65 to 85 years), were included. The overall prevalence of sarcopenia was 21.7% (n=34). After adjusting for sex, age and education, inadequate adherence to Mediterranean Diet (MD) (OR=10.90; 95% CI:1.41-84.52), current smoking status (OR=5.06; 95% CI:1.06-24.18) and poorer self-perceived health (OR=2.74; 95% CI:1.03-7.28) were positively associated with sarcopenia. No other statistically significant associations were found.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The observed sarcopenia frequency underscores the need for enhanced screening and management of this condition in community settings and among those at dementia risk. Inadequate adherence to MD, smoking and poor self-perceived health, seem to be associated with sarcopenia in older adults at high risk of dementia. Sarcopenia prevention should involve a holistic approach to promoting a healthy lifestyle.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>Sarcopenia was observed in 21.7% of older adults at high risk of dementia, indicating a significant burden on this vulnerable population.</jats:p> <jats:p>Inadequate adherence to the Mediterranean diet, smoking and poor self-perceived health were associated with sarcopenia.</jats:p> </jats:sec>
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
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status_str publishedVersion
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url https://hdl.handle.net/10216/162462
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1093/eurpub/ckae144.1346
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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repository.mail.fl_str_mv mluisa.alvim@gmail.com
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