A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells

Detalhes bibliográficos
Autor(a) principal: Seco, Pedro
Data de Publicação: 2020
Outros Autores: Martins, Gabriel G., Jacinto, António, Tavares, Ana Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/108670
Resumo: FUNDING This work was supported by the FCT – Fundação para a Ciência e a Tecnologia, I.P. (PTDC/BTM-SAL/29377/2017) and iNOVA4Health (UID/Multi/04462/2019). The Advanced Imaging Facility of the Instituto Gulbenkian de Ciência was supported by national Portuguese funding co-financed by the Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and FCT (PPBI-POCI-01- 0145-FEDER-022122). AT was funded by the FCT in the context of a program contract under “Norma Transitória” (DL57/2016 of 29 August, as amended by DL57/2017 of 19 July).
id RCAP_50cf45a1dcd5d0ca2fcb1f06461a2c2b
oai_identifier_str oai:run.unl.pt:10362/108670
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cellsavian embryodorsal aortahemangioblasthemogenic endotheliumlineage-tracingyolk sacDevelopmental BiologyCell BiologyFUNDING This work was supported by the FCT – Fundação para a Ciência e a Tecnologia, I.P. (PTDC/BTM-SAL/29377/2017) and iNOVA4Health (UID/Multi/04462/2019). The Advanced Imaging Facility of the Instituto Gulbenkian de Ciência was supported by national Portuguese funding co-financed by the Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and FCT (PPBI-POCI-01- 0145-FEDER-022122). AT was funded by the FCT in the context of a program contract under “Norma Transitória” (DL57/2016 of 29 August, as amended by DL57/2017 of 19 July).During early embryogenesis, the hemogenic endothelium of the developing dorsal aorta is the main source of definitive hematopoietic stem cells (HSCs), which will generate all blood cell lineages of the adult organism. The hemogenic endothelial cells (HECs) of the dorsal aorta are known to arise from the splanchnic lateral plate mesoderm. However, the specific cell lineages and developmental paths that give rise to aortic HECs are still unclear. Over the past half a century, the scientific debate on the origin of aortic HECs and HSCs has largely focused on two potential and apparently alternative birthplaces, the extraembryonic yolk sac blood islands and the intraembryonic splanchnic mesoderm. However, as we argue, both yolk sac blood islands and aortic HECs may have a common hemangioblastic origin. Further insight into aortic HEC development is being gained from fate-mapping studies that address the identity of progenitor cell lineages, rather than their physical location within the developing embryo. In this perspective article, we discuss the current knowledge on the origin of aortic HECs with a particular focus on the evidence provided by studies in the avian embryo, a model that pioneered the field of developmental hematopoiesis.iNOVA4Health - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSeco, PedroMartins, Gabriel G.Jacinto, AntónioTavares, Ana Teresa2020-12-15T05:28:35Z2020-11-172020-11-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/108670engPURE: 26838731https://doi.org/10.3389/fcell.2020.605274info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:53:09Zoai:run.unl.pt:10362/108670Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:41:13.379549Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
title A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
spellingShingle A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
Seco, Pedro
avian embryo
dorsal aorta
hemangioblast
hemogenic endothelium
lineage-tracing
yolk sac
Developmental Biology
Cell Biology
title_short A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
title_full A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
title_fullStr A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
title_full_unstemmed A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
title_sort A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells
author Seco, Pedro
author_facet Seco, Pedro
Martins, Gabriel G.
Jacinto, António
Tavares, Ana Teresa
author_role author
author2 Martins, Gabriel G.
Jacinto, António
Tavares, Ana Teresa
author2_role author
author
author
dc.contributor.none.fl_str_mv iNOVA4Health - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Seco, Pedro
Martins, Gabriel G.
Jacinto, António
Tavares, Ana Teresa
dc.subject.por.fl_str_mv avian embryo
dorsal aorta
hemangioblast
hemogenic endothelium
lineage-tracing
yolk sac
Developmental Biology
Cell Biology
topic avian embryo
dorsal aorta
hemangioblast
hemogenic endothelium
lineage-tracing
yolk sac
Developmental Biology
Cell Biology
description FUNDING This work was supported by the FCT – Fundação para a Ciência e a Tecnologia, I.P. (PTDC/BTM-SAL/29377/2017) and iNOVA4Health (UID/Multi/04462/2019). The Advanced Imaging Facility of the Instituto Gulbenkian de Ciência was supported by national Portuguese funding co-financed by the Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and FCT (PPBI-POCI-01- 0145-FEDER-022122). AT was funded by the FCT in the context of a program contract under “Norma Transitória” (DL57/2016 of 29 August, as amended by DL57/2017 of 19 July).
publishDate 2020
dc.date.none.fl_str_mv 2020-12-15T05:28:35Z
2020-11-17
2020-11-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/108670
url http://hdl.handle.net/10362/108670
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 26838731
https://doi.org/10.3389/fcell.2020.605274
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138025654976512

Registros relacionados