Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.13/2976 |
Resumo: | A male West African sample from Guinea-Bissau (West-African coast) was genetically analyzed using 12 X chromosomal short tandem repeats that are grouped into four haplotype groups. Linkage disequilibrium was tested (p ≤ 0.0008) and association was detected for the majority of markers in three out of the four studied haplotype clusters. The sample of 332 unrelated individuals analyzed in this study belonged to several recognized ethnic groups (n = 18) which were used to evaluate the genetic variation of Guinea-Bissau’s population. Pairwise genetic distances (FST) did not reveal significant differences among the majority of groups. An additional 110 samples from other countries also belonging to West Africa were as well compared with the sample of Guinea-Bissau. No significant differences were found between these two groups of West African individuals, supporting the genetic homogeneity of this region on the X chromosome level. The generation of over 100 DNA West African sequences provided new insights into the repeat sequence structure of some of the present X-STRs. Parameters for forensic evaluation were also calculated for each X-STR, supporting the potential application of these markers in typical kinship scenarios. Also, the high power of discrimination values for samples of female and male origin observed in this study, confirms the usefulness of the present X-STRs in identification analysis. |
id |
RCAP_50f1b8466249eb9bfe272b8c306303b5 |
---|---|
oai_identifier_str |
oai:digituma.uma.pt:10400.13/2976 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic populationGuinea-BissauWest AfricaX- STRsInvestigator Argus X-12Forensic genetics.Faculdade de Ciências da VidaA male West African sample from Guinea-Bissau (West-African coast) was genetically analyzed using 12 X chromosomal short tandem repeats that are grouped into four haplotype groups. Linkage disequilibrium was tested (p ≤ 0.0008) and association was detected for the majority of markers in three out of the four studied haplotype clusters. The sample of 332 unrelated individuals analyzed in this study belonged to several recognized ethnic groups (n = 18) which were used to evaluate the genetic variation of Guinea-Bissau’s population. Pairwise genetic distances (FST) did not reveal significant differences among the majority of groups. An additional 110 samples from other countries also belonging to West Africa were as well compared with the sample of Guinea-Bissau. No significant differences were found between these two groups of West African individuals, supporting the genetic homogeneity of this region on the X chromosome level. The generation of over 100 DNA West African sequences provided new insights into the repeat sequence structure of some of the present X-STRs. Parameters for forensic evaluation were also calculated for each X-STR, supporting the potential application of these markers in typical kinship scenarios. Also, the high power of discrimination values for samples of female and male origin observed in this study, confirms the usefulness of the present X-STRs in identification analysis.ElsevierDigitUMaGomes, IvaPereira, Plácido J.P.Harms, SonjaOliveira, Andréa M.Schneider, Peter M.Brehm, António2020-11-13T11:54:14Z2017-01-01T00:00:00Z2017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/2976engGomes, I., Pereira, P. J., Harms, S., Oliveira, A. M., Schneider, P. M., & Brehm, A. (2017). Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population. Forensic Science International: Genetics, 31, 89-94.10.1016/j.fsigen.2017.08.016info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T12:55:52Zoai:digituma.uma.pt:10400.13/2976Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:05:48.978642Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
title |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
spellingShingle |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population Gomes, Iva Guinea-Bissau West Africa X- STRs Investigator Argus X-12 Forensic genetics . Faculdade de Ciências da Vida |
title_short |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
title_full |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
title_fullStr |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
title_full_unstemmed |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
title_sort |
Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population |
author |
Gomes, Iva |
author_facet |
Gomes, Iva Pereira, Plácido J.P. Harms, Sonja Oliveira, Andréa M. Schneider, Peter M. Brehm, António |
author_role |
author |
author2 |
Pereira, Plácido J.P. Harms, Sonja Oliveira, Andréa M. Schneider, Peter M. Brehm, António |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
DigitUMa |
dc.contributor.author.fl_str_mv |
Gomes, Iva Pereira, Plácido J.P. Harms, Sonja Oliveira, Andréa M. Schneider, Peter M. Brehm, António |
dc.subject.por.fl_str_mv |
Guinea-Bissau West Africa X- STRs Investigator Argus X-12 Forensic genetics . Faculdade de Ciências da Vida |
topic |
Guinea-Bissau West Africa X- STRs Investigator Argus X-12 Forensic genetics . Faculdade de Ciências da Vida |
description |
A male West African sample from Guinea-Bissau (West-African coast) was genetically analyzed using 12 X chromosomal short tandem repeats that are grouped into four haplotype groups. Linkage disequilibrium was tested (p ≤ 0.0008) and association was detected for the majority of markers in three out of the four studied haplotype clusters. The sample of 332 unrelated individuals analyzed in this study belonged to several recognized ethnic groups (n = 18) which were used to evaluate the genetic variation of Guinea-Bissau’s population. Pairwise genetic distances (FST) did not reveal significant differences among the majority of groups. An additional 110 samples from other countries also belonging to West Africa were as well compared with the sample of Guinea-Bissau. No significant differences were found between these two groups of West African individuals, supporting the genetic homogeneity of this region on the X chromosome level. The generation of over 100 DNA West African sequences provided new insights into the repeat sequence structure of some of the present X-STRs. Parameters for forensic evaluation were also calculated for each X-STR, supporting the potential application of these markers in typical kinship scenarios. Also, the high power of discrimination values for samples of female and male origin observed in this study, confirms the usefulness of the present X-STRs in identification analysis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01T00:00:00Z 2017-01-01T00:00:00Z 2020-11-13T11:54:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.13/2976 |
url |
http://hdl.handle.net/10400.13/2976 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gomes, I., Pereira, P. J., Harms, S., Oliveira, A. M., Schneider, P. M., & Brehm, A. (2017). Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: inferences from a multiethnic population. Forensic Science International: Genetics, 31, 89-94. 10.1016/j.fsigen.2017.08.016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799129929401499648 |