Neurovascular and neurometabolic derailment in aging and Alzheimer's disease
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109135 https://doi.org/10.3389/fnagi.2015.00103 |
Resumo: | The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide ((•)NO) is a key player in both phenomena. Alterations in the mechanisms underlying the intimate communication between neural cells and vessels ultimately lead to neuronal dysfunction. Both neurovascular and neurometabolic coupling are perturbed during brain aging and in age-related neuropathologies in close association with cognitive decline. However, despite decades of intense investigation, many aspects remain poorly understood, such as the impact of these alterations. In this review, we address neurovascular and neurometabolic derailment in aging and Alzheimer's disease (AD), discussing its significance in connection with (•)NO-related pathways. |
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Neurovascular and neurometabolic derailment in aging and Alzheimer's diseaseneurovascular couplingneurometabolismnitricoxideAlzheimer’s diseaseagingThe functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide ((•)NO) is a key player in both phenomena. Alterations in the mechanisms underlying the intimate communication between neural cells and vessels ultimately lead to neuronal dysfunction. Both neurovascular and neurometabolic coupling are perturbed during brain aging and in age-related neuropathologies in close association with cognitive decline. However, despite decades of intense investigation, many aspects remain poorly understood, such as the impact of these alterations. In this review, we address neurovascular and neurometabolic derailment in aging and Alzheimer's disease (AD), discussing its significance in connection with (•)NO-related pathways.Frontiers Media S.A.2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109135http://hdl.handle.net/10316/109135https://doi.org/10.3389/fnagi.2015.00103eng1663-4365Lourenço, Cátia F.Ledo, AnaDias, CândidaBarbosa, Rui M.Laranjinha, Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-28T12:01:23Zoai:estudogeral.uc.pt:10316/109135Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:20.185991Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
title |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
spellingShingle |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease Lourenço, Cátia F. neurovascular coupling neurometabolism nitricoxide Alzheimer’s disease aging |
title_short |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
title_full |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
title_fullStr |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
title_full_unstemmed |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
title_sort |
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease |
author |
Lourenço, Cátia F. |
author_facet |
Lourenço, Cátia F. Ledo, Ana Dias, Cândida Barbosa, Rui M. Laranjinha, João |
author_role |
author |
author2 |
Ledo, Ana Dias, Cândida Barbosa, Rui M. Laranjinha, João |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lourenço, Cátia F. Ledo, Ana Dias, Cândida Barbosa, Rui M. Laranjinha, João |
dc.subject.por.fl_str_mv |
neurovascular coupling neurometabolism nitricoxide Alzheimer’s disease aging |
topic |
neurovascular coupling neurometabolism nitricoxide Alzheimer’s disease aging |
description |
The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide ((•)NO) is a key player in both phenomena. Alterations in the mechanisms underlying the intimate communication between neural cells and vessels ultimately lead to neuronal dysfunction. Both neurovascular and neurometabolic coupling are perturbed during brain aging and in age-related neuropathologies in close association with cognitive decline. However, despite decades of intense investigation, many aspects remain poorly understood, such as the impact of these alterations. In this review, we address neurovascular and neurometabolic derailment in aging and Alzheimer's disease (AD), discussing its significance in connection with (•)NO-related pathways. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109135 http://hdl.handle.net/10316/109135 https://doi.org/10.3389/fnagi.2015.00103 |
url |
http://hdl.handle.net/10316/109135 https://doi.org/10.3389/fnagi.2015.00103 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1663-4365 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134136421580800 |