Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds

Detalhes bibliográficos
Autor(a) principal: Silva, Jordana Benfica
Data de Publicação: 2024
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/41881
Resumo: Hydrotropy is considered a more recent approach that satisfies the relevant principles of green engineering and chemistry. Hydrotropes are amphiphilic molecules with a balanced hydrophobic and hydrophilic part with a tendency to self-aggregate above the minimum hydrotropic concentration. This thesis is related to the investigation of alternative solvents as hydrotropes to increase the solubility of compounds that are not very soluble in water. In addition to investigating the solubilization mechanism through the development of experimental data sets to measure solubility curves supported by spectroscopy and mathematical modeling techniques. Initially, in order to create new applications for these alternative solvents, ionic liquids, eutectic solvents, inorganic salts and bio-based solvents are used to increase the solubility of hydrophobic compounds with a wide range of applications in the pharmaceutical and food industries. Then, based on solubility curves and supported by spectroscopic techniques, solubilization mechanisms are addressed in order to clarify and justify the chemical mechanisms that govern the increase in solubility provided by the hydrotropes studied here.
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spelling Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compoundsHydrotropySolubilityIonic liquidsEutectic solventsInorganic saltsBio based solventsSolublization mechanismPH effectNuclear magnetic resonanceHydrotropy is considered a more recent approach that satisfies the relevant principles of green engineering and chemistry. Hydrotropes are amphiphilic molecules with a balanced hydrophobic and hydrophilic part with a tendency to self-aggregate above the minimum hydrotropic concentration. This thesis is related to the investigation of alternative solvents as hydrotropes to increase the solubility of compounds that are not very soluble in water. In addition to investigating the solubilization mechanism through the development of experimental data sets to measure solubility curves supported by spectroscopy and mathematical modeling techniques. Initially, in order to create new applications for these alternative solvents, ionic liquids, eutectic solvents, inorganic salts and bio-based solvents are used to increase the solubility of hydrophobic compounds with a wide range of applications in the pharmaceutical and food industries. Then, based on solubility curves and supported by spectroscopic techniques, solubilization mechanisms are addressed in order to clarify and justify the chemical mechanisms that govern the increase in solubility provided by the hydrotropes studied here.A hidrotropia é considerada uma abordagem mais recente que satisfaz os princípios relevantes da engenharia e química verdes. Hidrotrópicos são moléculas anfifílicas com uma parte hidrofóbica e hidrofílica equilibrada com tendência a se auto-agregar acima da concentração mínima de hidrótropos. Esta tese está relacionada com a investigações de solventes alternativos como hidrótropos para aumentar a solubilidade de compostos pouco solúveis em água. Além de investigar mecanismo de solubilização através do desenvolvimento de conjuntos de dados experimentais para medir as curvas de solubilidade apoiado a técnicas de espectroscopia e modelagem matemática. Inicialmente, de forma a criar novas aplicações para estes solventes alternativos, líquidos iónicos, solventes eutéticos, sais inorgânicos e solventes de base biológica são utilizados para aumentar a solubilidade de compostos hidrofóbicos com ampla gama de aplicação na indústria farmacêutica e alimentar. Depois, com base nas curvas de solubilidade e apoiado a técnicas de espectroscopia, mecanismo de solubilização são abordados a fim de esclarecer e justificar os mecanismos químicos que regem o aumento de solubilidade proporcionado pelos hidrótropos aqui estudados.2024-05-14T13:32:37Z2024-04-15T00:00:00Z2024-04-15doctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10773/41881engSilva, Jordana Benficainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-27T01:46:30Zoai:ria.ua.pt:10773/41881Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-27T01:46:30Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
title Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
spellingShingle Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
Silva, Jordana Benfica
Hydrotropy
Solubility
Ionic liquids
Eutectic solvents
Inorganic salts
Bio based solvents
Solublization mechanism
PH effect
Nuclear magnetic resonance
title_short Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
title_full Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
title_fullStr Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
title_full_unstemmed Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
title_sort Unlocking the hydrotropy potential of alternative solvents for the solubilization of target compounds
author Silva, Jordana Benfica
author_facet Silva, Jordana Benfica
author_role author
dc.contributor.author.fl_str_mv Silva, Jordana Benfica
dc.subject.por.fl_str_mv Hydrotropy
Solubility
Ionic liquids
Eutectic solvents
Inorganic salts
Bio based solvents
Solublization mechanism
PH effect
Nuclear magnetic resonance
topic Hydrotropy
Solubility
Ionic liquids
Eutectic solvents
Inorganic salts
Bio based solvents
Solublization mechanism
PH effect
Nuclear magnetic resonance
description Hydrotropy is considered a more recent approach that satisfies the relevant principles of green engineering and chemistry. Hydrotropes are amphiphilic molecules with a balanced hydrophobic and hydrophilic part with a tendency to self-aggregate above the minimum hydrotropic concentration. This thesis is related to the investigation of alternative solvents as hydrotropes to increase the solubility of compounds that are not very soluble in water. In addition to investigating the solubilization mechanism through the development of experimental data sets to measure solubility curves supported by spectroscopy and mathematical modeling techniques. Initially, in order to create new applications for these alternative solvents, ionic liquids, eutectic solvents, inorganic salts and bio-based solvents are used to increase the solubility of hydrophobic compounds with a wide range of applications in the pharmaceutical and food industries. Then, based on solubility curves and supported by spectroscopic techniques, solubilization mechanisms are addressed in order to clarify and justify the chemical mechanisms that govern the increase in solubility provided by the hydrotropes studied here.
publishDate 2024
dc.date.none.fl_str_mv 2024-05-14T13:32:37Z
2024-04-15T00:00:00Z
2024-04-15
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/41881
url http://hdl.handle.net/10773/41881
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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