Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure

Detalhes bibliográficos
Autor(a) principal: Antunes de Almeida, Gustavo
Data de Publicação: 2020
Outros Autores: Custódio, Sara, Órfão, João, Campos, Ana, Estibeiro, Hugo, Montalvão, Pedro, Magalhães, Miguel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.34631/sporl.851
Resumo: Objective: Analyze salvage total laryngectomy as treatment in recurrence after organ preserving strategy (QRT/RT), determine recurrence rates, survival and predictive factors. Study design: Retrospective charts review. Materials and methods: Salvage total laryngectomy patients, from 2005 to 2017. Univariate analysis with T Student, Mann Whitney, survival estimates with Kaplan-Meier method and Cox proportional hazards model. Results and conclusions: 63 patients, 95,24% male, mean age 56,75<7,9 years. 12,7% supraglotic location, 71,2% glotic and 15,9% transglotic. Primary tumor T stage was 54% T1/T2, 46% T3, N stage 69,8% N0 and 30,2% N+. T1/T2 group had 91,2% 2-year survival rate vs 62,1% for T3 stage. For N0 2-year survival rate was 88,6% vs 52,6% for N+ patients, glotic tumors had a 2-year survival rate of 84,4% vs 61,1% for non-glotic. Total laryngectomy in salvage setting is safe and effective, primary T and N stage, tumor location and age were identified as predictive factors of survival. 
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spelling Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failureLaringectomia de resgate para cancro recorrente da laringe após após falência de tratamento não cirúrgicoLarynxSalvage laryngectomyLaringeal cancertotal laryngectomyLaringeLaringectomia de resgateLaringectomia salvagecancro da laringecarcinoma da laringelaringectomia totalObjective: Analyze salvage total laryngectomy as treatment in recurrence after organ preserving strategy (QRT/RT), determine recurrence rates, survival and predictive factors. Study design: Retrospective charts review. Materials and methods: Salvage total laryngectomy patients, from 2005 to 2017. Univariate analysis with T Student, Mann Whitney, survival estimates with Kaplan-Meier method and Cox proportional hazards model. Results and conclusions: 63 patients, 95,24% male, mean age 56,75<7,9 years. 12,7% supraglotic location, 71,2% glotic and 15,9% transglotic. Primary tumor T stage was 54% T1/T2, 46% T3, N stage 69,8% N0 and 30,2% N+. T1/T2 group had 91,2% 2-year survival rate vs 62,1% for T3 stage. For N0 2-year survival rate was 88,6% vs 52,6% for N+ patients, glotic tumors had a 2-year survival rate of 84,4% vs 61,1% for non-glotic. Total laryngectomy in salvage setting is safe and effective, primary T and N stage, tumor location and age were identified as predictive factors of survival. Objetivos: Avaliar o papel terapêutico da laringectomia salvage na recorrência de doença após terapêutica conservadora (QRT/RT) em doentes com CPC da laringe, determinar taxas de recorrência, sobrevida e fatores preditivos de sobrevida. Desenho do estudo: Análise retrospetiva. Material e Métodos: Selecionados doentes com neoplasia recorrente ou persistente da laringe submetidos a laringectomia salvage entre 2005 e 2017. Análise estatística com testes T de Studente Mann Whitney, pelo método Kaplan-Meier e regressão Cox. Resultados e conclusões: Identificados 63 doentes, 95,24% homens, idade média 56,75<7,9 anos. Distribuição dos tumores 12,7% supraglóticos, 71,2% glóticos, 15,9% transglóticos. Estadiamento inicial da doença: a) local 54% T1/T2, 46% T3; b) regional 69,8% N0, 30,2% N+. Sobrevida a 2 anos T1/T2 foi 91,2% vs 62,1% (T3), para N0 88,6% vs N+ 52,6% (p<0,001), tumores glóticos 84,4% vs 61,1% não glóticos. A laringectomia total de resgate é eficaz e segura. O estadiamento local e regional, localização do tumor e idade são fatores preditivos de sobrevida. Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2020-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34631/sporl.851https://doi.org/10.34631/sporl.851Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 58 No. 3 (2020): Setembro; 145-150Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 58 Núm. 3 (2020): Setembro; 145-150Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 58 N.º 3 (2020): Setembro; 145-1502184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://journalsporl.com/index.php/sporl/article/view/2239https://journalsporl.com/index.php/sporl/article/view/2239/211Direitos de Autor (c) 2020 Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessAntunes de Almeida, GustavoCustódio, SaraÓrfão, JoãoCampos, AnaEstibeiro, HugoMontalvão, PedroMagalhães, Miguel2024-06-06T12:57:32Zoai:journalsporl.com:article/2239Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-06-06T12:57:32Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
Laringectomia de resgate para cancro recorrente da laringe após após falência de tratamento não cirúrgico
title Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
spellingShingle Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
Antunes de Almeida, Gustavo
Larynx
Salvage laryngectomy
Laringeal cancer
total laryngectomy
Laringe
Laringectomia de resgate
Laringectomia salvage
cancro da laringe
carcinoma da laringe
laringectomia total
title_short Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
title_full Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
title_fullStr Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
title_full_unstemmed Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
title_sort Salvage laryngectomy for recurrent larynx cancer after nonsurgical treatment failure
author Antunes de Almeida, Gustavo
author_facet Antunes de Almeida, Gustavo
Custódio, Sara
Órfão, João
Campos, Ana
Estibeiro, Hugo
Montalvão, Pedro
Magalhães, Miguel
author_role author
author2 Custódio, Sara
Órfão, João
Campos, Ana
Estibeiro, Hugo
Montalvão, Pedro
Magalhães, Miguel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Antunes de Almeida, Gustavo
Custódio, Sara
Órfão, João
Campos, Ana
Estibeiro, Hugo
Montalvão, Pedro
Magalhães, Miguel
dc.subject.por.fl_str_mv Larynx
Salvage laryngectomy
Laringeal cancer
total laryngectomy
Laringe
Laringectomia de resgate
Laringectomia salvage
cancro da laringe
carcinoma da laringe
laringectomia total
topic Larynx
Salvage laryngectomy
Laringeal cancer
total laryngectomy
Laringe
Laringectomia de resgate
Laringectomia salvage
cancro da laringe
carcinoma da laringe
laringectomia total
description Objective: Analyze salvage total laryngectomy as treatment in recurrence after organ preserving strategy (QRT/RT), determine recurrence rates, survival and predictive factors. Study design: Retrospective charts review. Materials and methods: Salvage total laryngectomy patients, from 2005 to 2017. Univariate analysis with T Student, Mann Whitney, survival estimates with Kaplan-Meier method and Cox proportional hazards model. Results and conclusions: 63 patients, 95,24% male, mean age 56,75<7,9 years. 12,7% supraglotic location, 71,2% glotic and 15,9% transglotic. Primary tumor T stage was 54% T1/T2, 46% T3, N stage 69,8% N0 and 30,2% N+. T1/T2 group had 91,2% 2-year survival rate vs 62,1% for T3 stage. For N0 2-year survival rate was 88,6% vs 52,6% for N+ patients, glotic tumors had a 2-year survival rate of 84,4% vs 61,1% for non-glotic. Total laryngectomy in salvage setting is safe and effective, primary T and N stage, tumor location and age were identified as predictive factors of survival. 
publishDate 2020
dc.date.none.fl_str_mv 2020-10-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.34631/sporl.851
https://doi.org/10.34631/sporl.851
url https://doi.org/10.34631/sporl.851
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://journalsporl.com/index.php/sporl/article/view/2239
https://journalsporl.com/index.php/sporl/article/view/2239/211
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.source.none.fl_str_mv Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 58 No. 3 (2020): Setembro; 145-150
Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 58 Núm. 3 (2020): Setembro; 145-150
Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 58 N.º 3 (2020): Setembro; 145-150
2184-6499
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817546026920181760

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