Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal

Detalhes bibliográficos
Autor(a) principal: Igrejas, Gilberto
Data de Publicação: 2018
Outros Autores: Correia, Susana, Silva, Vanessa, Hébraud, Michel, Caniça, Manuela, Torres, Carmen, Gomes, Catarina, Nogueira, Fernanda, Poeta, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6312
Resumo: Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292916/
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spelling Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in PortugalMethicillin-resistant Staphylococcus aureusMRSAOne HealthAntimicrobial ResistanceOmicsSurveillanceResistência aos AntimicrobianosFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292916/Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important multidrug-resistant nosocomial pathogens worldwide with infections leading to high rates of morbidity and mortality, a significant burden to human and veterinary clinical practices. The ability of S. aureus colonies to form biofilms on biotic and abiotic surfaces contributes further to its high antimicrobial resistance (AMR) rates and persistence in both host and non-host environments, adding a major ecological dimension to the problem. While there is a lot of information on MRSA prevalence in humans, data about MRSA in animal populations is scarce, incomplete and dispersed. This project is an attempt to evaluate the current epidemiological status of MRSA in Portugal by making a single case study from a One Health perspective. We aim to determine the prevalence of MRSA in anthropogenic sources liable to contaminate different animal habitats. The results obtained will be compiled with existing data on antibiotic resistant staphylococci from Portugal in a user-friendly database, to generate a geographically detailed epidemiological output for surveillance of AMR in MRSA. To achieve this, we will first characterize AMR and genetic lineages of MRSA circulating in northern Portugal in hospital wastewaters, farms near hospitals, farm animals that contact with humans, and wild animals. This will indicate the extent of the AMR problem in the context of local and regional human-animal-environment interactions. MRSA strains will then be tested for their ability to form biofilms. The proteomes of the strains will be compared to better elucidate their AMR mechanisms. Proteomics data will be integrated with the genomic and transcriptomic data obtained. The vast amount of information expected from this omics approach will improve our understanding of AMR in MRSA biofilms, and help us identify new vaccine candidates and biomarkers for early diagnosis and innovative therapeutic strategies to tackle MRSA biofilm-associated infections and potentially other AMR superbugs.This article is based upon work from COST Action (‘Network for Evaluation of One Health’, NEOH, TD14040), supported by COST (European Cooperation in Science and Technology). The authors are grateful to the Associate Laboratory Research Unit for Green Chemistry (LAQV), which is financed by National Funds from FCT/MEC (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 partnership agreement (POCI-01-0145- FEDER – 007265).Frontiers MediaRepositório Científico do Instituto Nacional de SaúdeIgrejas, GilbertoCorreia, SusanaSilva, VanessaHébraud, MichelCaniça, ManuelaTorres, CarmenGomes, CatarinaNogueira, FernandaPoeta, Patrícia2019-03-26T16:01:58Z2018-12-072018-12-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6312engFront Microbiol. 2018 Dec 7;9:2964. doi: 10.3389/fmicb.2018.02964. eCollection 2018.1664-302X10.3389/fmicb.2018.02964info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:20Zoai:repositorio.insa.pt:10400.18/6312Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:57.659867Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
title Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
spellingShingle Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
Igrejas, Gilberto
Methicillin-resistant Staphylococcus aureus
MRSA
One Health
Antimicrobial Resistance
Omics
Surveillance
Resistência aos Antimicrobianos
title_short Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
title_full Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
title_fullStr Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
title_full_unstemmed Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
title_sort Planning a One Health Case Study to Evaluate Methicillin Resistant Staphylococcus aureus and Its Economic Burden in Portugal
author Igrejas, Gilberto
author_facet Igrejas, Gilberto
Correia, Susana
Silva, Vanessa
Hébraud, Michel
Caniça, Manuela
Torres, Carmen
Gomes, Catarina
Nogueira, Fernanda
Poeta, Patrícia
author_role author
author2 Correia, Susana
Silva, Vanessa
Hébraud, Michel
Caniça, Manuela
Torres, Carmen
Gomes, Catarina
Nogueira, Fernanda
Poeta, Patrícia
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Igrejas, Gilberto
Correia, Susana
Silva, Vanessa
Hébraud, Michel
Caniça, Manuela
Torres, Carmen
Gomes, Catarina
Nogueira, Fernanda
Poeta, Patrícia
dc.subject.por.fl_str_mv Methicillin-resistant Staphylococcus aureus
MRSA
One Health
Antimicrobial Resistance
Omics
Surveillance
Resistência aos Antimicrobianos
topic Methicillin-resistant Staphylococcus aureus
MRSA
One Health
Antimicrobial Resistance
Omics
Surveillance
Resistência aos Antimicrobianos
description Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292916/
publishDate 2018
dc.date.none.fl_str_mv 2018-12-07
2018-12-07T00:00:00Z
2019-03-26T16:01:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6312
url http://hdl.handle.net/10400.18/6312
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Microbiol. 2018 Dec 7;9:2964. doi: 10.3389/fmicb.2018.02964. eCollection 2018.
1664-302X
10.3389/fmicb.2018.02964
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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