Natural-based hydrogels for tissue engineering applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/68545 |
Resumo: | In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissuesâ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies. |
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Natural-based hydrogels for tissue engineering applicationsAnisotropyBiomimeticBlood derivativesDecellularized tissueDNAExtracellular matrixGlycosaminoglycansNanoparticlesProteinsSupramolecular crosslinkingScience & TechnologyIn the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissuesâ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.Authors acknowledge financial support from the European Union Framework Programme for Research and Innovation Horizon 2020 under European Research Council grant agreement No. 772817; FCT (Fundação para a Ciência e a Tecnologia) for individual fellowship CEECIND/01375/2017 (MGF); FCT for project PTDC/NAN-MAT/30595/2017; Xunta de Galicia for postdoctoral fellowship ED481B-2019-025 (AP); Norwegian Research Council (NFR) for project No. 287953.MDPIUniversidade do MinhoGomez-Florit, ManuelPardo, AlbertoDomingues, Rui Miguel AndradeGraça, Ana L.Babo, Pedro Miguel SousaReis, R. L.Gomes, Manuela E.2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68545engGómez-Florit M., Pardo A., Domingues R. M. A., Graça A. L., Babo P. S., Reis R. L., Gomes M. E. Natural-Based Hydrogels for Tissue Engineering Applications, Molecules, Vol. 25, Issue 24, pp. 5858, doi:10.3390/molecules25245858, 20201420-304910.3390/molecules2524585833322369https://www.mdpi.com/1420-3049/25/24/5858info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:46:24Zoai:repositorium.sdum.uminho.pt:1822/68545Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:44:23.608642Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Natural-based hydrogels for tissue engineering applications |
title |
Natural-based hydrogels for tissue engineering applications |
spellingShingle |
Natural-based hydrogels for tissue engineering applications Gomez-Florit, Manuel Anisotropy Biomimetic Blood derivatives Decellularized tissue DNA Extracellular matrix Glycosaminoglycans Nanoparticles Proteins Supramolecular crosslinking Science & Technology |
title_short |
Natural-based hydrogels for tissue engineering applications |
title_full |
Natural-based hydrogels for tissue engineering applications |
title_fullStr |
Natural-based hydrogels for tissue engineering applications |
title_full_unstemmed |
Natural-based hydrogels for tissue engineering applications |
title_sort |
Natural-based hydrogels for tissue engineering applications |
author |
Gomez-Florit, Manuel |
author_facet |
Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui Miguel Andrade Graça, Ana L. Babo, Pedro Miguel Sousa Reis, R. L. Gomes, Manuela E. |
author_role |
author |
author2 |
Pardo, Alberto Domingues, Rui Miguel Andrade Graça, Ana L. Babo, Pedro Miguel Sousa Reis, R. L. Gomes, Manuela E. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui Miguel Andrade Graça, Ana L. Babo, Pedro Miguel Sousa Reis, R. L. Gomes, Manuela E. |
dc.subject.por.fl_str_mv |
Anisotropy Biomimetic Blood derivatives Decellularized tissue DNA Extracellular matrix Glycosaminoglycans Nanoparticles Proteins Supramolecular crosslinking Science & Technology |
topic |
Anisotropy Biomimetic Blood derivatives Decellularized tissue DNA Extracellular matrix Glycosaminoglycans Nanoparticles Proteins Supramolecular crosslinking Science & Technology |
description |
In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissuesâ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 2020-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/68545 |
url |
http://hdl.handle.net/1822/68545 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gómez-Florit M., Pardo A., Domingues R. M. A., Graça A. L., Babo P. S., Reis R. L., Gomes M. E. Natural-Based Hydrogels for Tissue Engineering Applications, Molecules, Vol. 25, Issue 24, pp. 5858, doi:10.3390/molecules25245858, 2020 1420-3049 10.3390/molecules25245858 33322369 https://www.mdpi.com/1420-3049/25/24/5858 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133004886441984 |