Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds

Detalhes bibliográficos
Autor(a) principal: Mancini, Simona
Data de Publicação: 2018
Outros Autores: Nardo, Luca, Gregori, Maria, Ribeiro, Inês, Mantegazza, Francesco, Delerue-Matos, Cristina, Masserini, Massimo, Grosso, Clara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14710
Resumo: Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.
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spelling Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compoundsAnnonaAntioxidantsBlood-Brain BarrierDrug CarriersEndothelial CellsFree Radical ScavengersHumansHydrogen PeroxideLiposomesMonoamine Oxidase InhibitorsNanostructuresPhenolsPlant ExtractsMulti-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.This work was financed through project UID/QUI/50006/2013, receiving financial support from FCT/MEC through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. C. G. thanks FCT for the FCT Investigator(/IF/01332/2014/CP1255/CT0001). The authors would also like to acknowledge Sílvia Maia from CEMUP for her technical assistance with LTQ Orbitrap XL analyses and to Professor Michael Clifford for his advices in analyzing the MS spectra of phenolic acids.SpringerRepositório Científico do Instituto Politécnico do PortoMancini, SimonaNardo, LucaGregori, MariaRibeiro, InêsMantegazza, FrancescoDelerue-Matos, CristinaMasserini, MassimoGrosso, Clara2019-10-07T14:29:02Z2018-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14710eng0944-711310.1016/j.phymed.2018.03.053info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:57:46Zoai:recipp.ipp.pt:10400.22/14710Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:14.648726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
title Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
spellingShingle Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
Mancini, Simona
Annona
Antioxidants
Blood-Brain Barrier
Drug Carriers
Endothelial Cells
Free Radical Scavengers
Humans
Hydrogen Peroxide
Liposomes
Monoamine Oxidase Inhibitors
Nanostructures
Phenols
Plant Extracts
title_short Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
title_full Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
title_fullStr Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
title_full_unstemmed Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
title_sort Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
author Mancini, Simona
author_facet Mancini, Simona
Nardo, Luca
Gregori, Maria
Ribeiro, Inês
Mantegazza, Francesco
Delerue-Matos, Cristina
Masserini, Massimo
Grosso, Clara
author_role author
author2 Nardo, Luca
Gregori, Maria
Ribeiro, Inês
Mantegazza, Francesco
Delerue-Matos, Cristina
Masserini, Massimo
Grosso, Clara
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Mancini, Simona
Nardo, Luca
Gregori, Maria
Ribeiro, Inês
Mantegazza, Francesco
Delerue-Matos, Cristina
Masserini, Massimo
Grosso, Clara
dc.subject.por.fl_str_mv Annona
Antioxidants
Blood-Brain Barrier
Drug Carriers
Endothelial Cells
Free Radical Scavengers
Humans
Hydrogen Peroxide
Liposomes
Monoamine Oxidase Inhibitors
Nanostructures
Phenols
Plant Extracts
topic Annona
Antioxidants
Blood-Brain Barrier
Drug Carriers
Endothelial Cells
Free Radical Scavengers
Humans
Hydrogen Peroxide
Liposomes
Monoamine Oxidase Inhibitors
Nanostructures
Phenols
Plant Extracts
description Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
2018-01-01T00:00:00Z
2019-10-07T14:29:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14710
url http://hdl.handle.net/10400.22/14710
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0944-7113
10.1016/j.phymed.2018.03.053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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