Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release

Detalhes bibliográficos
Autor(a) principal: Lopes, Mafalda
Data de Publicação: 2021
Outros Autores: Restani, Rita, Carvalho, Marco António Paulo de, Correia, I.J., Ricardo, Ana Aguiar, Bonifácio, Vasco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/11112
Resumo: Chitosan, a natural and abundant biopolymer has been long explored as a biocompatible material for the preparation of drug delivery devices. This strategy has been mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking has been shown to reduce both biocompatibility and swelling. In this work chitosan was crosslinked with novel biocompatible crosslinkers, based on oligo-oxazolines and glycidyl methacrylate copolymers, leading to patches with a very high swelling capacity. Dexamethasone therapeutics is strongly enhanced by a controlled release administration. This study shows that oligo-oxazoline-crosslinked chitosan is a suitable biomaterial for loading and controlled release of dexamethasone.
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spelling Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug releaseOligo-oxazolinesChitosanCrosslinkingSupercritical carbon dioxideDexamethasoneChitosan, a natural and abundant biopolymer has been long explored as a biocompatible material for the preparation of drug delivery devices. This strategy has been mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking has been shown to reduce both biocompatibility and swelling. In this work chitosan was crosslinked with novel biocompatible crosslinkers, based on oligo-oxazolines and glycidyl methacrylate copolymers, leading to patches with a very high swelling capacity. Dexamethasone therapeutics is strongly enhanced by a controlled release administration. This study shows that oligo-oxazoline-crosslinked chitosan is a suitable biomaterial for loading and controlled release of dexamethasone.uBibliorumLopes, MafaldaRestani, RitaCarvalho, Marco António Paulo deCorreia, I.J.Ricardo, Ana AguiarBonifácio, Vasco2023-02-20T01:30:19Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/11112eng10.1016/j.reactfunctpolym.2021.104846info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:53:22Zoai:ubibliorum.ubi.pt:10400.6/11112Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:50:57.924789Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
title Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
spellingShingle Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
Lopes, Mafalda
Oligo-oxazolines
Chitosan
Crosslinking
Supercritical carbon dioxide
Dexamethasone
title_short Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
title_full Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
title_fullStr Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
title_full_unstemmed Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
title_sort Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release
author Lopes, Mafalda
author_facet Lopes, Mafalda
Restani, Rita
Carvalho, Marco António Paulo de
Correia, I.J.
Ricardo, Ana Aguiar
Bonifácio, Vasco
author_role author
author2 Restani, Rita
Carvalho, Marco António Paulo de
Correia, I.J.
Ricardo, Ana Aguiar
Bonifácio, Vasco
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Lopes, Mafalda
Restani, Rita
Carvalho, Marco António Paulo de
Correia, I.J.
Ricardo, Ana Aguiar
Bonifácio, Vasco
dc.subject.por.fl_str_mv Oligo-oxazolines
Chitosan
Crosslinking
Supercritical carbon dioxide
Dexamethasone
topic Oligo-oxazolines
Chitosan
Crosslinking
Supercritical carbon dioxide
Dexamethasone
description Chitosan, a natural and abundant biopolymer has been long explored as a biocompatible material for the preparation of drug delivery devices. This strategy has been mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking has been shown to reduce both biocompatibility and swelling. In this work chitosan was crosslinked with novel biocompatible crosslinkers, based on oligo-oxazolines and glycidyl methacrylate copolymers, leading to patches with a very high swelling capacity. Dexamethasone therapeutics is strongly enhanced by a controlled release administration. This study shows that oligo-oxazoline-crosslinked chitosan is a suitable biomaterial for loading and controlled release of dexamethasone.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2023-02-20T01:30:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/11112
url http://hdl.handle.net/10400.6/11112
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.reactfunctpolym.2021.104846
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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