Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469

Detalhes bibliográficos
Autor(a) principal: Leal, Inês
Data de Publicação: 2018
Outros Autores: Sousa, David Cordeiro, Costa, João, Vaz-Carneiro, António
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660
Resumo: Non-infectious uveitis is a heterogeneous collection of inflammatory eye diseases and is one of the most important causes of blindness among active adults in developed countries. Inflammation control is crucial in the prevention of ocular structural and functional damage. Regarding acute inflammatory control, corticosteroids are the mainstay of treatment. Several types of intra-ocular corticosteroids have been used with the aim of enhanced efficacy compared to their topical or peri-ocular administration, while minimizing its adverse effects associated with the systemic administration. The purpose of this Cochrane review was to synthetize the available evidence regarding the efficacy and safety of corticosteroid implants in comparison with standard treatment. Due to the heterogeneity in the design of the studies and outcome measures assessed, authors could not conclude that implants are superior to traditional systemic therapy in Non-infectious uveitis. The safety analysis suggested increased risks of post-implant surgery for cataract and high intraocular pressure compared with standard-of-care therapy.
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spelling Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469Análise da Revisão Cochrane: Implantes de Corticóides na Uveíte Não-Infecciosa Crónica. Cochrane Database Syst Rev. 2016;2:CD010469Adrenal Cortex Hormones/administration & dosageDrug ImplantsRandomized Controlled Trials as TopicUveitis/drug therapyCorticosteroides/administração e dosagemImplantes de MedicamentoRevisão sistemáticaUveíte/tratamentoNon-infectious uveitis is a heterogeneous collection of inflammatory eye diseases and is one of the most important causes of blindness among active adults in developed countries. Inflammation control is crucial in the prevention of ocular structural and functional damage. Regarding acute inflammatory control, corticosteroids are the mainstay of treatment. Several types of intra-ocular corticosteroids have been used with the aim of enhanced efficacy compared to their topical or peri-ocular administration, while minimizing its adverse effects associated with the systemic administration. The purpose of this Cochrane review was to synthetize the available evidence regarding the efficacy and safety of corticosteroid implants in comparison with standard treatment. Due to the heterogeneity in the design of the studies and outcome measures assessed, authors could not conclude that implants are superior to traditional systemic therapy in Non-infectious uveitis. The safety analysis suggested increased risks of post-implant surgery for cataract and high intraocular pressure compared with standard-of-care therapy.A uveíte não infecciosa inclui várias patologias com elevada morbilidade, sendo uma das causas mais importantes de cegueira na população activa de países desenvolvidos. O controlo da inflamação é essencial na prevenção do dano estrutural e funcional às estruturas oculares. Sendo os corticóides fármacos de primeira linha no controlo agudo da inflamação, têm sido usadas formulações intra-oculares destes fármacos, com o objectivo de aumentar a eficácia face ao uso tópico ou periocular e de induzir menos efeitos adversos secundários comparativamente ao uso sistémico. O objectivo desta revisão Cochrane foi sintetizar a evidência existente sobre a eficácia e segurança de implantes de corticóides intravítreos, em comparação com a terapêutica convencional. Devido à heterogeneidade no desenho e medidas de eficácia utilizadas, os autores não conseguiram demonstrar superioridade dos implantes intravítreos de corticóides em comparação com a terapêutica convencional, na uveíte não infecciosa. A análise de segurança sugere que estes possam aumentar a probabilidade de necessidade de cirurgia de catarata e de elevação da pressão intraocular, em comparação com a terapêutica standard.Ordem dos Médicos2018-05-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660oai:ojs.www.actamedicaportuguesa.com:article/10660Acta Médica Portuguesa; Vol. 31 No. 5 (2018): May; 243-246Acta Médica Portuguesa; Vol. 31 N.º 5 (2018): Maio; 243-2461646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660/5418https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660/10316Direitos de Autor (c) 2018 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessLeal, InêsSousa, David CordeiroCosta, JoãoVaz-Carneiro, António2022-12-20T11:06:03Zoai:ojs.www.actamedicaportuguesa.com:article/10660Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:55.506879Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
Análise da Revisão Cochrane: Implantes de Corticóides na Uveíte Não-Infecciosa Crónica. Cochrane Database Syst Rev. 2016;2:CD010469
title Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
spellingShingle Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
Leal, Inês
Adrenal Cortex Hormones/administration & dosage
Drug Implants
Randomized Controlled Trials as Topic
Uveitis/drug therapy
Corticosteroides/administração e dosagem
Implantes de Medicamento
Revisão sistemática
Uveíte/tratamento
title_short Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
title_full Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
title_fullStr Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
title_full_unstemmed Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
title_sort Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469
author Leal, Inês
author_facet Leal, Inês
Sousa, David Cordeiro
Costa, João
Vaz-Carneiro, António
author_role author
author2 Sousa, David Cordeiro
Costa, João
Vaz-Carneiro, António
author2_role author
author
author
dc.contributor.author.fl_str_mv Leal, Inês
Sousa, David Cordeiro
Costa, João
Vaz-Carneiro, António
dc.subject.por.fl_str_mv Adrenal Cortex Hormones/administration & dosage
Drug Implants
Randomized Controlled Trials as Topic
Uveitis/drug therapy
Corticosteroides/administração e dosagem
Implantes de Medicamento
Revisão sistemática
Uveíte/tratamento
topic Adrenal Cortex Hormones/administration & dosage
Drug Implants
Randomized Controlled Trials as Topic
Uveitis/drug therapy
Corticosteroides/administração e dosagem
Implantes de Medicamento
Revisão sistemática
Uveíte/tratamento
description Non-infectious uveitis is a heterogeneous collection of inflammatory eye diseases and is one of the most important causes of blindness among active adults in developed countries. Inflammation control is crucial in the prevention of ocular structural and functional damage. Regarding acute inflammatory control, corticosteroids are the mainstay of treatment. Several types of intra-ocular corticosteroids have been used with the aim of enhanced efficacy compared to their topical or peri-ocular administration, while minimizing its adverse effects associated with the systemic administration. The purpose of this Cochrane review was to synthetize the available evidence regarding the efficacy and safety of corticosteroid implants in comparison with standard treatment. Due to the heterogeneity in the design of the studies and outcome measures assessed, authors could not conclude that implants are superior to traditional systemic therapy in Non-infectious uveitis. The safety analysis suggested increased risks of post-implant surgery for cataract and high intraocular pressure compared with standard-of-care therapy.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-30
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv por
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language por
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660/5418
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10660/10316
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2018 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2018 Acta Médica Portuguesa
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 31 No. 5 (2018): May; 243-246
Acta Médica Portuguesa; Vol. 31 N.º 5 (2018): Maio; 243-246
1646-0758
0870-399X
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