Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1371/journal.pone.0185866 |
Resumo: | Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV clusters (2 subtype F1 and one CRF14_BG) and thirteen smaller HCV transmission networks (genotypes 1a, 1b, 3a, 4a and 4d) were identified. Eighty (65%) patients were both in HIV and HCV transmission chains and 70 of those shared the same HIV and HCV cluster with at least one other patient. Molecular clock analysis indicated that all identified HIV clusters originated around 2006, while the origin of the different HCV clusters ranged between 1980 (genotype 1b) and 2011 (genotypes 3a and 4d). HCV infection preceded HIV infection in 80.3% of cases. Coincidental transmission of HIV and HCV was estimated to be rather low (19.65%) and associated with an outbreak among PWID during detention in the same penitentiary. This study has reconstructed and compared the dispersion of these two viruses in a PWID population. |
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Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug usersHEPATITIS-CMOLECULAR EPIDEMIOLOGYVIRUS-INFECTIONHIGH PREVALENCESUBTYPE F1PEOPLESEQUENCESGENOTYPESSPREADRISKEpidemiologyInfectious DiseasesBiochemistry, Genetics and Molecular Biology (miscellaneous)Ecology, Evolution, Behavior and SystematicsSDG 3 - Good Health and Well-beingCo-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV clusters (2 subtype F1 and one CRF14_BG) and thirteen smaller HCV transmission networks (genotypes 1a, 1b, 3a, 4a and 4d) were identified. Eighty (65%) patients were both in HIV and HCV transmission chains and 70 of those shared the same HIV and HCV cluster with at least one other patient. Molecular clock analysis indicated that all identified HIV clusters originated around 2006, while the origin of the different HCV clusters ranged between 1980 (genotype 1b) and 2011 (genotypes 3a and 4d). HCV infection preceded HIV infection in 80.3% of cases. Coincidental transmission of HIV and HCV was estimated to be rather low (19.65%) and associated with an outbreak among PWID during detention in the same penitentiary. This study has reconstructed and compared the dispersion of these two viruses in a PWID population.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)TB, HIV and opportunistic diseases and pathogens (THOP)RUNParaschiv, SimonaBanica, LeontinaNicolae, IoneliaNiculescu, IuliaAbagiu, AdrianJipa, RalucaPineda-Peña, Andrea ClemenciaPingarilho, MartaNeaga, EmilTheys, KristofLibin, PieterOtelea, DanAbecasis, Ana2018-05-10T22:18:11Z2017-10-012017-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1371/journal.pone.0185866eng1932-6203PURE: 3255973http://www.scopus.com/inward/record.url?scp=85031014330&partnerID=8YFLogxKhttps://doi.org/10.1371/journal.pone.0185866info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:19:54Zoai:run.unl.pt:10362/36491Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:31.203971Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
title |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
spellingShingle |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users Paraschiv, Simona HEPATITIS-C MOLECULAR EPIDEMIOLOGY VIRUS-INFECTION HIGH PREVALENCE SUBTYPE F1 PEOPLE SEQUENCES GENOTYPES SPREAD RISK Epidemiology Infectious Diseases Biochemistry, Genetics and Molecular Biology (miscellaneous) Ecology, Evolution, Behavior and Systematics SDG 3 - Good Health and Well-being |
title_short |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
title_full |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
title_fullStr |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
title_full_unstemmed |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
title_sort |
Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users |
author |
Paraschiv, Simona |
author_facet |
Paraschiv, Simona Banica, Leontina Nicolae, Ionelia Niculescu, Iulia Abagiu, Adrian Jipa, Raluca Pineda-Peña, Andrea Clemencia Pingarilho, Marta Neaga, Emil Theys, Kristof Libin, Pieter Otelea, Dan Abecasis, Ana |
author_role |
author |
author2 |
Banica, Leontina Nicolae, Ionelia Niculescu, Iulia Abagiu, Adrian Jipa, Raluca Pineda-Peña, Andrea Clemencia Pingarilho, Marta Neaga, Emil Theys, Kristof Libin, Pieter Otelea, Dan Abecasis, Ana |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) TB, HIV and opportunistic diseases and pathogens (THOP) RUN |
dc.contributor.author.fl_str_mv |
Paraschiv, Simona Banica, Leontina Nicolae, Ionelia Niculescu, Iulia Abagiu, Adrian Jipa, Raluca Pineda-Peña, Andrea Clemencia Pingarilho, Marta Neaga, Emil Theys, Kristof Libin, Pieter Otelea, Dan Abecasis, Ana |
dc.subject.por.fl_str_mv |
HEPATITIS-C MOLECULAR EPIDEMIOLOGY VIRUS-INFECTION HIGH PREVALENCE SUBTYPE F1 PEOPLE SEQUENCES GENOTYPES SPREAD RISK Epidemiology Infectious Diseases Biochemistry, Genetics and Molecular Biology (miscellaneous) Ecology, Evolution, Behavior and Systematics SDG 3 - Good Health and Well-being |
topic |
HEPATITIS-C MOLECULAR EPIDEMIOLOGY VIRUS-INFECTION HIGH PREVALENCE SUBTYPE F1 PEOPLE SEQUENCES GENOTYPES SPREAD RISK Epidemiology Infectious Diseases Biochemistry, Genetics and Molecular Biology (miscellaneous) Ecology, Evolution, Behavior and Systematics SDG 3 - Good Health and Well-being |
description |
Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV clusters (2 subtype F1 and one CRF14_BG) and thirteen smaller HCV transmission networks (genotypes 1a, 1b, 3a, 4a and 4d) were identified. Eighty (65%) patients were both in HIV and HCV transmission chains and 70 of those shared the same HIV and HCV cluster with at least one other patient. Molecular clock analysis indicated that all identified HIV clusters originated around 2006, while the origin of the different HCV clusters ranged between 1980 (genotype 1b) and 2011 (genotypes 3a and 4d). HCV infection preceded HIV infection in 80.3% of cases. Coincidental transmission of HIV and HCV was estimated to be rather low (19.65%) and associated with an outbreak among PWID during detention in the same penitentiary. This study has reconstructed and compared the dispersion of these two viruses in a PWID population. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 2017-10-01T00:00:00Z 2018-05-10T22:18:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1371/journal.pone.0185866 |
url |
https://doi.org/10.1371/journal.pone.0185866 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1932-6203 PURE: 3255973 http://www.scopus.com/inward/record.url?scp=85031014330&partnerID=8YFLogxK https://doi.org/10.1371/journal.pone.0185866 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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