Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/47162 |
Resumo: | Copyright © 2020 Miyazaki, Marin-Mogollon, Imai, Mendes, van der Laak, Sturm, Geurten, Miyazaki, Chevalley-Maurel, Ramesar, Kolli, Kroeze, van Schuijlenburg, Salman, Wilder, Reyes-Sandoval, Dechering, Prudencio, Janse, Khan and ̂ Franke-Fayard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine developmentPlasmodium falciparumPlasmodium vivaxChimeric parasitesCircumsporozoite protein (CSP)MalariaVaccinesCopyright © 2020 Miyazaki, Marin-Mogollon, Imai, Mendes, van der Laak, Sturm, Geurten, Miyazaki, Chevalley-Maurel, Ramesar, Kolli, Kroeze, van Schuijlenburg, Salman, Wilder, Reyes-Sandoval, Dechering, Prudencio, Janse, Khan and ̂ Franke-Fayard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Chimeric rodent malaria parasites with the endogenous circumsporozoite protein (csp) gene replaced with csp from the human parasites Plasmodium falciparum (Pf) and P. vivax (Pv) are used in preclinical evaluation of CSP vaccines. Chimeric rodent parasites expressing PfCSP have also been assessed as whole sporozoite (WSP) vaccines. Comparable chimeric P. falciparum parasites expressing CSP of P. vivax could be used both for clinical evaluation of vaccines targeting PvCSP in controlled human P. falciparum infections and in WSP vaccines targeting P. vivax and P. falciparum. We generated chimeric P. falciparum parasites expressing both PfCSP and PvCSP. These Pf-PvCSP parasites produced sporozoite comparable to wild type P. falciparum parasites and expressed PfCSP and PvCSP on the sporozoite surface. Pf-PvCSP sporozoites infected human hepatocytes and induced antibodies to the repeats of both PfCSP and PvCSP after immunization of mice. These results support the use of Pf-PvCSP sporozoites in studies optimizing vaccines targeting PvCSP.CM-M was, in part, supported by Colciencias Ph.D. fellowship (Call 568 from 2012 Resolution 01218 Bogotá, Colombia). TI was, in part, supported by Uehara Memorial Foundation grant. Work performed at IMM was supported by Fundação para a Ciência e Tecnologia (FCT-Portugal)’s grants PTDC/BBB-BMD/2695/2014 and PTDC-SAU-INF-29550-2017. AR-S is supported by the MRC-DPFS grant MR/N019008/1.FrontiersRepositório da Universidade de LisboaMiyazaki, YukikoMarin-Mogollon, CatherinImai, TakashiMendes, António M.van der Laak, RianneSturm, AngelikaGeurten, Fiona J. A.Miyazaki, ShinyaChevalley-Maurel, SeverineRamesar, JaiKolli, Surendra K.Kroeze, Hansvan Schuijlenburg, RoosSalman, Ahmed M.Wilder, Brandon K.Reyes-Sandoval, ArturoDechering, Koen J.Prudêncio, MiguelJanse, Chris J.Khan, Shahid M.Franke-Fayard, Blandine2021-03-30T15:42:05Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47162engFront Cell Infect Microbiol. 2020 Dec 17;10:59104610.3389/fcimb.2020.5910462235-2988info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:51Zoai:repositorio.ul.pt:10451/47162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:14.589917Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| title |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| spellingShingle |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development Miyazaki, Yukiko Plasmodium falciparum Plasmodium vivax Chimeric parasites Circumsporozoite protein (CSP) Malaria Vaccines |
| title_short |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| title_full |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| title_fullStr |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| title_full_unstemmed |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| title_sort |
Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development |
| author |
Miyazaki, Yukiko |
| author_facet |
Miyazaki, Yukiko Marin-Mogollon, Catherin Imai, Takashi Mendes, António M. van der Laak, Rianne Sturm, Angelika Geurten, Fiona J. A. Miyazaki, Shinya Chevalley-Maurel, Severine Ramesar, Jai Kolli, Surendra K. Kroeze, Hans van Schuijlenburg, Roos Salman, Ahmed M. Wilder, Brandon K. Reyes-Sandoval, Arturo Dechering, Koen J. Prudêncio, Miguel Janse, Chris J. Khan, Shahid M. Franke-Fayard, Blandine |
| author_role |
author |
| author2 |
Marin-Mogollon, Catherin Imai, Takashi Mendes, António M. van der Laak, Rianne Sturm, Angelika Geurten, Fiona J. A. Miyazaki, Shinya Chevalley-Maurel, Severine Ramesar, Jai Kolli, Surendra K. Kroeze, Hans van Schuijlenburg, Roos Salman, Ahmed M. Wilder, Brandon K. Reyes-Sandoval, Arturo Dechering, Koen J. Prudêncio, Miguel Janse, Chris J. Khan, Shahid M. Franke-Fayard, Blandine |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Miyazaki, Yukiko Marin-Mogollon, Catherin Imai, Takashi Mendes, António M. van der Laak, Rianne Sturm, Angelika Geurten, Fiona J. A. Miyazaki, Shinya Chevalley-Maurel, Severine Ramesar, Jai Kolli, Surendra K. Kroeze, Hans van Schuijlenburg, Roos Salman, Ahmed M. Wilder, Brandon K. Reyes-Sandoval, Arturo Dechering, Koen J. Prudêncio, Miguel Janse, Chris J. Khan, Shahid M. Franke-Fayard, Blandine |
| dc.subject.por.fl_str_mv |
Plasmodium falciparum Plasmodium vivax Chimeric parasites Circumsporozoite protein (CSP) Malaria Vaccines |
| topic |
Plasmodium falciparum Plasmodium vivax Chimeric parasites Circumsporozoite protein (CSP) Malaria Vaccines |
| description |
Copyright © 2020 Miyazaki, Marin-Mogollon, Imai, Mendes, van der Laak, Sturm, Geurten, Miyazaki, Chevalley-Maurel, Ramesar, Kolli, Kroeze, van Schuijlenburg, Salman, Wilder, Reyes-Sandoval, Dechering, Prudencio, Janse, Khan and ̂ Franke-Fayard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-03-30T15:42:05Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/47162 |
| url |
http://hdl.handle.net/10451/47162 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Front Cell Infect Microbiol. 2020 Dec 17;10:591046 10.3389/fcimb.2020.591046 2235-2988 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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