Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats

Detalhes bibliográficos
Autor(a) principal: Sagradas, Joana
Data de Publicação: 2015
Outros Autores: Costa, Gustavo, Figueirinha, Artur, Castel-Branco, Maria Margarida, Silvério Cabrita, António Manuel, Figueiredo, Isabel Vitória, Batista, Maria Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/101128
https://doi.org/10.1016/j.jep.2015.07.001
Resumo: Ethnopharmacological relevance: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. Materials and methods: The study was performed on adult male Wistar rats (234.0722.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. Results: C. citratus extract, given orally before or after ethanol, significantly (Po0.01) reduced gastric mucosal injury compared with control group (vehicleþethanol). The effect does not appear to be dosedependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. Conclusions: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use.
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spelling Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in ratsCymbopogon citratusLemongrass InfusionInfusionGastric ulcerGastroprotectiveEthnopharmacological relevance: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. Materials and methods: The study was performed on adult male Wistar rats (234.0722.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. Results: C. citratus extract, given orally before or after ethanol, significantly (Po0.01) reduced gastric mucosal injury compared with control group (vehicleþethanol). The effect does not appear to be dosedependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. Conclusions: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use.3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANOinfo:eu-repo/semantics/publishedVersionElsevier2015-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/101128http://hdl.handle.net/10316/101128https://doi.org/10.1016/j.jep.2015.07.001eng0378-8741cv-prod-144373Sagradas, JoanaCosta, GustavoFigueirinha, ArturCastel-Branco, Maria MargaridaSilvério Cabrita, António ManuelFigueiredo, Isabel VitóriaBatista, Maria Teresainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-21T08:36:58Zoai:estudogeral.uc.pt:10316/101128Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:18:21.947388Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
title Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
spellingShingle Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
Sagradas, Joana
Cymbopogon citratus
Lemongrass Infusion
Infusion
Gastric ulcer
Gastroprotective
title_short Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
title_full Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
title_fullStr Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
title_full_unstemmed Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
title_sort Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
author Sagradas, Joana
author_facet Sagradas, Joana
Costa, Gustavo
Figueirinha, Artur
Castel-Branco, Maria Margarida
Silvério Cabrita, António Manuel
Figueiredo, Isabel Vitória
Batista, Maria Teresa
author_role author
author2 Costa, Gustavo
Figueirinha, Artur
Castel-Branco, Maria Margarida
Silvério Cabrita, António Manuel
Figueiredo, Isabel Vitória
Batista, Maria Teresa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sagradas, Joana
Costa, Gustavo
Figueirinha, Artur
Castel-Branco, Maria Margarida
Silvério Cabrita, António Manuel
Figueiredo, Isabel Vitória
Batista, Maria Teresa
dc.subject.por.fl_str_mv Cymbopogon citratus
Lemongrass Infusion
Infusion
Gastric ulcer
Gastroprotective
topic Cymbopogon citratus
Lemongrass Infusion
Infusion
Gastric ulcer
Gastroprotective
description Ethnopharmacological relevance: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. Materials and methods: The study was performed on adult male Wistar rats (234.0722.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. Results: C. citratus extract, given orally before or after ethanol, significantly (Po0.01) reduced gastric mucosal injury compared with control group (vehicleþethanol). The effect does not appear to be dosedependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. Conclusions: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/101128
http://hdl.handle.net/10316/101128
https://doi.org/10.1016/j.jep.2015.07.001
url http://hdl.handle.net/10316/101128
https://doi.org/10.1016/j.jep.2015.07.001
dc.language.iso.fl_str_mv eng
language eng
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cv-prod-144373
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publisher.none.fl_str_mv Elsevier
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