Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/101128 https://doi.org/10.1016/j.jep.2015.07.001 |
Resumo: | Ethnopharmacological relevance: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. Materials and methods: The study was performed on adult male Wistar rats (234.0722.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. Results: C. citratus extract, given orally before or after ethanol, significantly (Po0.01) reduced gastric mucosal injury compared with control group (vehicleþethanol). The effect does not appear to be dosedependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. Conclusions: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use. |
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Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in ratsCymbopogon citratusLemongrass InfusionInfusionGastric ulcerGastroprotectiveEthnopharmacological relevance: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. Materials and methods: The study was performed on adult male Wistar rats (234.0722.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. Results: C. citratus extract, given orally before or after ethanol, significantly (Po0.01) reduced gastric mucosal injury compared with control group (vehicleþethanol). The effect does not appear to be dosedependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. Conclusions: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use.3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANOinfo:eu-repo/semantics/publishedVersionElsevier2015-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/101128http://hdl.handle.net/10316/101128https://doi.org/10.1016/j.jep.2015.07.001eng0378-8741cv-prod-144373Sagradas, JoanaCosta, GustavoFigueirinha, ArturCastel-Branco, Maria MargaridaSilvério Cabrita, António ManuelFigueiredo, Isabel VitóriaBatista, Maria Teresainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-21T08:36:58Zoai:estudogeral.uc.pt:10316/101128Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:18:21.947388Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
title |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
spellingShingle |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats Sagradas, Joana Cymbopogon citratus Lemongrass Infusion Infusion Gastric ulcer Gastroprotective |
title_short |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
title_full |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
title_fullStr |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
title_full_unstemmed |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
title_sort |
Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats |
author |
Sagradas, Joana |
author_facet |
Sagradas, Joana Costa, Gustavo Figueirinha, Artur Castel-Branco, Maria Margarida Silvério Cabrita, António Manuel Figueiredo, Isabel Vitória Batista, Maria Teresa |
author_role |
author |
author2 |
Costa, Gustavo Figueirinha, Artur Castel-Branco, Maria Margarida Silvério Cabrita, António Manuel Figueiredo, Isabel Vitória Batista, Maria Teresa |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sagradas, Joana Costa, Gustavo Figueirinha, Artur Castel-Branco, Maria Margarida Silvério Cabrita, António Manuel Figueiredo, Isabel Vitória Batista, Maria Teresa |
dc.subject.por.fl_str_mv |
Cymbopogon citratus Lemongrass Infusion Infusion Gastric ulcer Gastroprotective |
topic |
Cymbopogon citratus Lemongrass Infusion Infusion Gastric ulcer Gastroprotective |
description |
Ethnopharmacological relevance: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. Materials and methods: The study was performed on adult male Wistar rats (234.0722.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. Results: C. citratus extract, given orally before or after ethanol, significantly (Po0.01) reduced gastric mucosal injury compared with control group (vehicleþethanol). The effect does not appear to be dosedependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. Conclusions: The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/101128 http://hdl.handle.net/10316/101128 https://doi.org/10.1016/j.jep.2015.07.001 |
url |
http://hdl.handle.net/10316/101128 https://doi.org/10.1016/j.jep.2015.07.001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0378-8741 cv-prod-144373 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134078365073408 |