Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours

Detalhes bibliográficos
Autor(a) principal: Albergaria, André
Data de Publicação: 2009
Outros Autores: Paredes, Joana, Sousa, Bárbara, Milanezi, Maria Fernanda Grillo, Carneiro, Vítor, Bastos, Joana, Costa, Sandra, Vieira, Daniella, Lopes, Nair, Lam, Eric W., Lunet, Nuno, Schmitt, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/67581
Resumo: The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERalpha, both encoding for transcription factors with a potential involvement in the ERalpha-mediated action in breast cancer. The purpose of this study was to explore if the expression of FOXA1 and GATA-3 may provide an opportunity to stratify subsets of patients that could have better outcome, among the ERalpha-negative/poor prognosis breast cancer group.
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spelling Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumoursAdultAgedAged, 80 and overDisease-Free SurvivalFemaleGATA3 Transcription FactorHepatocyte Nuclear Factor 3-alphaHumansImmunohistochemistryMiddle AgedPrognosisProportional Hazards ModelsReceptors, EstrogenTreatment OutcomeGene Expression Regulation, NeoplasticCiências Médicas::Medicina BásicaScience & TechnologyThe expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERalpha, both encoding for transcription factors with a potential involvement in the ERalpha-mediated action in breast cancer. The purpose of this study was to explore if the expression of FOXA1 and GATA-3 may provide an opportunity to stratify subsets of patients that could have better outcome, among the ERalpha-negative/poor prognosis breast cancer group.The present study was supported by a research grant (SFRH/BD/15316/ 2005 to AA) financed by the Portuguese Science and Technology Foundation (FCT). The authors thank Prof. Raquel Seruca ( coordinator from the Cancer Genetics group at IPATIMUP) for scientific assistance, Dr Jose Luis Costa (postdoctorate at IPATIMUP) for critically reading the manuscript before submission, and Dr Nuno Marcos ( PhD student at IPATIMUP) for artwork assistance.BioMed Central (BMC)Universidade do MinhoAlbergaria, AndréParedes, JoanaSousa, BárbaraMilanezi, Maria Fernanda GrilloCarneiro, VítorBastos, JoanaCosta, SandraVieira, DaniellaLopes, NairLam, Eric W.Lunet, NunoSchmitt, Fernando2009-062009-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67581engAlbergaria, A., Paredes, J., Sousa, B., Milanezi, F., et. al.(2009). Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast cancer research, 11(3), R401465-54111465-542X10.1186/bcr232719549328https://link.springer.com/article/10.1186/bcr2327info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:00:51Zoai:repositorium.sdum.uminho.pt:1822/67581Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:50:44.102455Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
title Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
spellingShingle Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
Albergaria, André
Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
GATA3 Transcription Factor
Hepatocyte Nuclear Factor 3-alpha
Humans
Immunohistochemistry
Middle Aged
Prognosis
Proportional Hazards Models
Receptors, Estrogen
Treatment Outcome
Gene Expression Regulation, Neoplastic
Ciências Médicas::Medicina Básica
Science & Technology
title_short Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
title_full Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
title_fullStr Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
title_full_unstemmed Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
title_sort Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
author Albergaria, André
author_facet Albergaria, André
Paredes, Joana
Sousa, Bárbara
Milanezi, Maria Fernanda Grillo
Carneiro, Vítor
Bastos, Joana
Costa, Sandra
Vieira, Daniella
Lopes, Nair
Lam, Eric W.
Lunet, Nuno
Schmitt, Fernando
author_role author
author2 Paredes, Joana
Sousa, Bárbara
Milanezi, Maria Fernanda Grillo
Carneiro, Vítor
Bastos, Joana
Costa, Sandra
Vieira, Daniella
Lopes, Nair
Lam, Eric W.
Lunet, Nuno
Schmitt, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Albergaria, André
Paredes, Joana
Sousa, Bárbara
Milanezi, Maria Fernanda Grillo
Carneiro, Vítor
Bastos, Joana
Costa, Sandra
Vieira, Daniella
Lopes, Nair
Lam, Eric W.
Lunet, Nuno
Schmitt, Fernando
dc.subject.por.fl_str_mv Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
GATA3 Transcription Factor
Hepatocyte Nuclear Factor 3-alpha
Humans
Immunohistochemistry
Middle Aged
Prognosis
Proportional Hazards Models
Receptors, Estrogen
Treatment Outcome
Gene Expression Regulation, Neoplastic
Ciências Médicas::Medicina Básica
Science & Technology
topic Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
GATA3 Transcription Factor
Hepatocyte Nuclear Factor 3-alpha
Humans
Immunohistochemistry
Middle Aged
Prognosis
Proportional Hazards Models
Receptors, Estrogen
Treatment Outcome
Gene Expression Regulation, Neoplastic
Ciências Médicas::Medicina Básica
Science & Technology
description The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERalpha, both encoding for transcription factors with a potential involvement in the ERalpha-mediated action in breast cancer. The purpose of this study was to explore if the expression of FOXA1 and GATA-3 may provide an opportunity to stratify subsets of patients that could have better outcome, among the ERalpha-negative/poor prognosis breast cancer group.
publishDate 2009
dc.date.none.fl_str_mv 2009-06
2009-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/67581
url http://hdl.handle.net/1822/67581
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Albergaria, A., Paredes, J., Sousa, B., Milanezi, F., et. al.(2009). Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast cancer research, 11(3), R40
1465-5411
1465-542X
10.1186/bcr2327
19549328
https://link.springer.com/article/10.1186/bcr2327
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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