Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/23513 |
Resumo: | Distal limb osteoarthritis (OA) is a common cause of lameness in horses and hyaluronic acid (HA) is frequently used, alone or in combination with other drugs, for intra-articular (IA) treatment. Therefore, we decided to investigate a product with high concentration of high molecular weight (HMW)-HA for a single IA injection that has been approved for humans (Goldenberg, 2014). The aim of this study was to assess the treatment efficacy and safety in horses using a body mounted inertial sensor device technology and synovial fluid (SF) analysis before and after treatment. In conclusion, our results suggest that high concentration of a single IA injection of HMW-HA in horses is safe, induce modest subjective lameness and asymmetry improvement and reduces TP in SF. This could represent an alternative, in the short-term period, to drugs that are forbidden in competition for pain relief while preserving joint metabolism. A randomized, double blind and controlled study, with a larger number of horses should be performed in order to confirm the clinical interest of this therapy. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horseshyaluronic acidhorsesintra-articularDistal limb osteoarthritis (OA) is a common cause of lameness in horses and hyaluronic acid (HA) is frequently used, alone or in combination with other drugs, for intra-articular (IA) treatment. Therefore, we decided to investigate a product with high concentration of high molecular weight (HMW)-HA for a single IA injection that has been approved for humans (Goldenberg, 2014). The aim of this study was to assess the treatment efficacy and safety in horses using a body mounted inertial sensor device technology and synovial fluid (SF) analysis before and after treatment. In conclusion, our results suggest that high concentration of a single IA injection of HMW-HA in horses is safe, induce modest subjective lameness and asymmetry improvement and reduces TP in SF. This could represent an alternative, in the short-term period, to drugs that are forbidden in competition for pain relief while preserving joint metabolism. A randomized, double blind and controlled study, with a larger number of horses should be performed in order to confirm the clinical interest of this therapy.Proceedings of ECVS Annual Scientific Meeting, 5-7 de Julho 2018, Atenas, Grécia2018-10-04T11:13:29Z2018-10-042018-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/23513http://hdl.handle.net/10174/23513engSingle intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses. Monteiro S., Bettencourt E., Branco S., Lepage O.M. (Proceedings of ECVS Annual Scientific Meeting, 5-7 de Julho 2018, Atenas, Grécia)ndndndnd206Monteiro, SOBettencourt, EVBranco, SMLepage, OMinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:15:43Zoai:dspace.uevora.pt:10174/23513Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:14:21.301960Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
title |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
spellingShingle |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses Monteiro, SO hyaluronic acid horses intra-articular |
title_short |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
title_full |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
title_fullStr |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
title_full_unstemmed |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
title_sort |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses |
author |
Monteiro, SO |
author_facet |
Monteiro, SO Bettencourt, EV Branco, SM Lepage, OM |
author_role |
author |
author2 |
Bettencourt, EV Branco, SM Lepage, OM |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Monteiro, SO Bettencourt, EV Branco, SM Lepage, OM |
dc.subject.por.fl_str_mv |
hyaluronic acid horses intra-articular |
topic |
hyaluronic acid horses intra-articular |
description |
Distal limb osteoarthritis (OA) is a common cause of lameness in horses and hyaluronic acid (HA) is frequently used, alone or in combination with other drugs, for intra-articular (IA) treatment. Therefore, we decided to investigate a product with high concentration of high molecular weight (HMW)-HA for a single IA injection that has been approved for humans (Goldenberg, 2014). The aim of this study was to assess the treatment efficacy and safety in horses using a body mounted inertial sensor device technology and synovial fluid (SF) analysis before and after treatment. In conclusion, our results suggest that high concentration of a single IA injection of HMW-HA in horses is safe, induce modest subjective lameness and asymmetry improvement and reduces TP in SF. This could represent an alternative, in the short-term period, to drugs that are forbidden in competition for pain relief while preserving joint metabolism. A randomized, double blind and controlled study, with a larger number of horses should be performed in order to confirm the clinical interest of this therapy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-04T11:13:29Z 2018-10-04 2018-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/23513 http://hdl.handle.net/10174/23513 |
url |
http://hdl.handle.net/10174/23513 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Single intra-articular injection of high concentrated hyaluronic acid – A pilot study in horses. Monteiro S., Bettencourt E., Branco S., Lepage O.M. (Proceedings of ECVS Annual Scientific Meeting, 5-7 de Julho 2018, Atenas, Grécia) nd nd nd nd 206 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Proceedings of ECVS Annual Scientific Meeting, 5-7 de Julho 2018, Atenas, Grécia |
publisher.none.fl_str_mv |
Proceedings of ECVS Annual Scientific Meeting, 5-7 de Julho 2018, Atenas, Grécia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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_version_ |
1799136625300602880 |