Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds

Detalhes bibliográficos
Autor(a) principal: Querido, Diana
Data de Publicação: 2022
Outros Autores: Vieira, Tânia, Ferreira, José Luís, Henriques, Célia, Borges, João Paulo, Silva, Jorge Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143378
Resumo: Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffoldscell adhesioncell proliferationchitosanco-electrospinningfibroblastshybrid scaffoldspolycaprolactonetissue engineeringChemistry(all)Polymers and PlasticsPublisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Hybrid scaffolds obtained by combining two or more biopolymers are studied in the context of tissue regeneration due to the possibility of achieving new functional properties or structural features. The aim of this work was to produce a new type of hybrid polycaprolactone (PCL)/chitosan (CS) electrospun mat through the controlled deposition of CS flakes interspaced between the PCL fibers. A poly(ethylene oxide) (PEO) solution was used to transport CS flakes with controlled size. This, and the PCL solution, were simultaneously electrospun onto a rotatory mandrel in a perpendicular setup. Different PCL/CS mass ratios were also studied. The morphology of the resulting fibers, evaluated by SEM, confirmed the presence of the CS flakes between the PCL fibers. The addition of PEO/CS fibers resulted in hydrophilic mats with lower Young's modulus relatively to PCL mats. In vitro cell culture results indicated that the addition of CS lowers both the adhesion and the proliferation of human dermal fibroblasts. The present work demonstrates the feasibility of achieving a controlled deposition of a polymeric component in granular form onto a collector where electrospun nanofibers are being deposited, thereby producing a hybrid scaffold.DF – Departamento de FísicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNQuerido, DianaVieira, TâniaFerreira, José LuísHenriques, CéliaBorges, João PauloSilva, Jorge Carvalho2022-08-30T22:26:43Z2022-04-072022-04-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/143378engPURE: 43940111https://doi.org/10.3390/polym14081496info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:21:42Zoai:run.unl.pt:10362/143378Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:54.697882Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
title Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
spellingShingle Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
Querido, Diana
cell adhesion
cell proliferation
chitosan
co-electrospinning
fibroblasts
hybrid scaffolds
polycaprolactone
tissue engineering
Chemistry(all)
Polymers and Plastics
title_short Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
title_full Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
title_fullStr Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
title_full_unstemmed Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
title_sort Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds
author Querido, Diana
author_facet Querido, Diana
Vieira, Tânia
Ferreira, José Luís
Henriques, Célia
Borges, João Paulo
Silva, Jorge Carvalho
author_role author
author2 Vieira, Tânia
Ferreira, José Luís
Henriques, Célia
Borges, João Paulo
Silva, Jorge Carvalho
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DF – Departamento de Física
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Querido, Diana
Vieira, Tânia
Ferreira, José Luís
Henriques, Célia
Borges, João Paulo
Silva, Jorge Carvalho
dc.subject.por.fl_str_mv cell adhesion
cell proliferation
chitosan
co-electrospinning
fibroblasts
hybrid scaffolds
polycaprolactone
tissue engineering
Chemistry(all)
Polymers and Plastics
topic cell adhesion
cell proliferation
chitosan
co-electrospinning
fibroblasts
hybrid scaffolds
polycaprolactone
tissue engineering
Chemistry(all)
Polymers and Plastics
description Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-30T22:26:43Z
2022-04-07
2022-04-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143378
url http://hdl.handle.net/10362/143378
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 43940111
https://doi.org/10.3390/polym14081496
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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