Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction

Detalhes bibliográficos
Autor(a) principal: Auxtero, Maria D.
Data de Publicação: 2021
Outros Autores: Chalante, Susana, Abade, Mário R., Jorge, Rui, Fernandes, Ana I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.15/3687
Resumo: Late-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.
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spelling Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunctionherb–drug interactionsbotanicalsfood supplementsnootropicsphytochemicalsnutraceuticalspharmacokineticscognitive dysfunctionLate-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.MDPIRepositório Científico do Instituto Politécnico de SantarémAuxtero, Maria D.Chalante, SusanaAbade, Mário R.Jorge, RuiFernandes, Ana I.2021-11-15T13:17:24Z2021-01-192021-01-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.15/3687engAuxtero, M.D.; Chalante, S.; Abade, M.R.; Jorge, R.; Fernandes, A.I. Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 2021, 13, 124. https://doi.org/ 10.3390/pharmaceutics130101241999-492310.3390/pharmaceutics13010124info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-21T07:35:46Zoai:repositorio.ipsantarem.pt:10400.15/3687Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:55:26.657238Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
title Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
spellingShingle Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
Auxtero, Maria D.
herb–drug interactions
botanicals
food supplements
nootropics
phytochemicals
nutraceuticals
pharmacokinetics
cognitive dysfunction
title_short Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
title_full Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
title_fullStr Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
title_full_unstemmed Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
title_sort Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
author Auxtero, Maria D.
author_facet Auxtero, Maria D.
Chalante, Susana
Abade, Mário R.
Jorge, Rui
Fernandes, Ana I.
author_role author
author2 Chalante, Susana
Abade, Mário R.
Jorge, Rui
Fernandes, Ana I.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Santarém
dc.contributor.author.fl_str_mv Auxtero, Maria D.
Chalante, Susana
Abade, Mário R.
Jorge, Rui
Fernandes, Ana I.
dc.subject.por.fl_str_mv herb–drug interactions
botanicals
food supplements
nootropics
phytochemicals
nutraceuticals
pharmacokinetics
cognitive dysfunction
topic herb–drug interactions
botanicals
food supplements
nootropics
phytochemicals
nutraceuticals
pharmacokinetics
cognitive dysfunction
description Late-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-15T13:17:24Z
2021-01-19
2021-01-19T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.15/3687
url http://hdl.handle.net/10400.15/3687
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Auxtero, M.D.; Chalante, S.; Abade, M.R.; Jorge, R.; Fernandes, A.I. Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 2021, 13, 124. https://doi.org/ 10.3390/pharmaceutics13010124
1999-4923
10.3390/pharmaceutics13010124
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dc.publisher.none.fl_str_mv MDPI
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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