Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.15/3687 |
Resumo: | Late-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice. |
id |
RCAP_545cd5278acb54aec000c2cba565ae00 |
---|---|
oai_identifier_str |
oai:repositorio.ipsantarem.pt:10400.15/3687 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunctionherb–drug interactionsbotanicalsfood supplementsnootropicsphytochemicalsnutraceuticalspharmacokineticscognitive dysfunctionLate-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.MDPIRepositório Científico do Instituto Politécnico de SantarémAuxtero, Maria D.Chalante, SusanaAbade, Mário R.Jorge, RuiFernandes, Ana I.2021-11-15T13:17:24Z2021-01-192021-01-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.15/3687engAuxtero, M.D.; Chalante, S.; Abade, M.R.; Jorge, R.; Fernandes, A.I. Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 2021, 13, 124. https://doi.org/ 10.3390/pharmaceutics130101241999-492310.3390/pharmaceutics13010124info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-21T07:35:46Zoai:repositorio.ipsantarem.pt:10400.15/3687Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:55:26.657238Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
title |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
spellingShingle |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction Auxtero, Maria D. herb–drug interactions botanicals food supplements nootropics phytochemicals nutraceuticals pharmacokinetics cognitive dysfunction |
title_short |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
title_full |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
title_fullStr |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
title_full_unstemmed |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
title_sort |
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction |
author |
Auxtero, Maria D. |
author_facet |
Auxtero, Maria D. Chalante, Susana Abade, Mário R. Jorge, Rui Fernandes, Ana I. |
author_role |
author |
author2 |
Chalante, Susana Abade, Mário R. Jorge, Rui Fernandes, Ana I. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Santarém |
dc.contributor.author.fl_str_mv |
Auxtero, Maria D. Chalante, Susana Abade, Mário R. Jorge, Rui Fernandes, Ana I. |
dc.subject.por.fl_str_mv |
herb–drug interactions botanicals food supplements nootropics phytochemicals nutraceuticals pharmacokinetics cognitive dysfunction |
topic |
herb–drug interactions botanicals food supplements nootropics phytochemicals nutraceuticals pharmacokinetics cognitive dysfunction |
description |
Late-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-15T13:17:24Z 2021-01-19 2021-01-19T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.15/3687 |
url |
http://hdl.handle.net/10400.15/3687 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Auxtero, M.D.; Chalante, S.; Abade, M.R.; Jorge, R.; Fernandes, A.I. Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction. Pharmaceutics 2021, 13, 124. https://doi.org/ 10.3390/pharmaceutics13010124 1999-4923 10.3390/pharmaceutics13010124 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1817553961127772160 |