Comprehensive Landscape of STEAP Family Members Expression in Human Cancers

Detalhes bibliográficos
Autor(a) principal: Rocha, Sandra M.
Data de Publicação: 2022
Outros Autores: Socorro, Sílvia, Passarinha, Luís A., Maia, Cláudio J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/144510
Resumo: Project No. 007491 Project No. 029114 LA/P/0140/2020 Centro-01-0145-FEDER-000019-C4
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spelling Comprehensive Landscape of STEAP Family Members Expression in Human CancersUnraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics AnalysiscBioPortalhuman cancersOncomineprognosisSTEAP membersInformation SystemsComputer Science ApplicationsInformation Systems and ManagementSDG 3 - Good Health and Well-beingProject No. 007491 Project No. 029114 LA/P/0140/2020 Centro-01-0145-FEDER-000019-C4The human Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) family com-prises STEAP1-4. Several studies have pointed out STEAP proteins as putative biomarkers, as well as therapeutic targets in several types of human cancers, particularly in prostate cancer. However, the relationships and significance of the expression pattern of STEAP1-4 in cancer cases are barely known. Herein, the Oncomine database and cBioPortal platform were selected to predict the differential expression levels of STEAP members and clinical prognosis. The most common expression pattern observed was the combination of the over-and underexpression of distinct STEAP genes, but cervical and gastric cancer and lymphoma showed overexpression of all STEAP genes. It was also found that STEAP genes’ expression levels were already deregulated in benign lesions. Regarding the prognostic value, it was found that STEAP1 (prostate), STEAP2 (brain and central nervous system), STEAP3 (kidney, leukemia and testicular) and STEAP4 (bladder, cervical, gastric) overexpression correlate with lower patient survival rate. However, in prostate cancer, overexpression of the STEAP4 gene was correlated with a higher survival rate. Overall, this study first showed that the expression levels of STEAP genes are highly variable in human cancers, which may be related to different patients’ outcomes.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNRocha, Sandra M.Socorro, SílviaPassarinha, Luís A.Maia, Cláudio J.2022-10-06T22:16:33Z2022-05-112022-05-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article48application/pdfhttp://hdl.handle.net/10362/144510eng2306-5729PURE: 46297629https://doi.org/10.3390/data7050064info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:24:10Zoai:run.unl.pt:10362/144510Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:35.986499Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
Unraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysis
title Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
spellingShingle Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
Rocha, Sandra M.
cBioPortal
human cancers
Oncomine
prognosis
STEAP members
Information Systems
Computer Science Applications
Information Systems and Management
SDG 3 - Good Health and Well-being
title_short Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
title_full Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
title_fullStr Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
title_full_unstemmed Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
title_sort Comprehensive Landscape of STEAP Family Members Expression in Human Cancers
author Rocha, Sandra M.
author_facet Rocha, Sandra M.
Socorro, Sílvia
Passarinha, Luís A.
Maia, Cláudio J.
author_role author
author2 Socorro, Sílvia
Passarinha, Luís A.
Maia, Cláudio J.
author2_role author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Rocha, Sandra M.
Socorro, Sílvia
Passarinha, Luís A.
Maia, Cláudio J.
dc.subject.por.fl_str_mv cBioPortal
human cancers
Oncomine
prognosis
STEAP members
Information Systems
Computer Science Applications
Information Systems and Management
SDG 3 - Good Health and Well-being
topic cBioPortal
human cancers
Oncomine
prognosis
STEAP members
Information Systems
Computer Science Applications
Information Systems and Management
SDG 3 - Good Health and Well-being
description Project No. 007491 Project No. 029114 LA/P/0140/2020 Centro-01-0145-FEDER-000019-C4
publishDate 2022
dc.date.none.fl_str_mv 2022-10-06T22:16:33Z
2022-05-11
2022-05-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/144510
url http://hdl.handle.net/10362/144510
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2306-5729
PURE: 46297629
https://doi.org/10.3390/data7050064
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 48
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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