The influence of ionic liquids on the solubility/permeation of poorly soluble active compounds

• Autor(a) principal: Caparica, Rita
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10437/8377
• topic: MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS; CIÊNCIAS FARMACÊUTICAS; FARMACOLOGIA; LÍQUIDOS IÓNICOS; SOLUBILIDADE; SISTEMAS DE LIBERTAÇÃO DE MEDICAMENTOS; PHARMACEUTICAL SCIENCES; PHARMACOLOGY; IONIC LIQUIDS; SOLUBILITY; DRUG DELIVERY SYSTEMS

The pharmaceutical industry has developed alternative forms of drug delivery over the years and the delivery through the skin, topical or transdermal delivery, has been increasingly used. However, incorporating poorly soluble or partially insoluble drugs into the developed delivery systems has been difficult to solve. Ionic liquids have specific properties, arising from their structure, which allows them to be used in aqueous, oily or hydroalcoholic solutions. Hence, ionic liquids can be used as excipients with the aim of increasing/improving the topical and transdermal delivery of drugs. Herein, the efficacy of ionic liquids derived from amino acids, [Cho][Phe] and [Cho][Glu], as solubility and/or permeation promoters of poorly soluble actives were evaluated. The studied actives were ferulic acid and rutin, both natural antioxidant compounds, with low solubility, which restricts their use in topical and dermocosmetic products, since they require the use of high proportions of organic solvents. The solubility studies carried out showed that the solubility of both active compounds is always increased in the presence of the prepared ionic liquids in all the studied conditions. Regarding the permeation studies, the ionic liquids did not shown a significant effect on the permeation of the studied actives. The obtained results indicate that the ionic liquids studied can be efficient functional ingredients, since they allow an increase in the solubility of the studied actives, even at low concentrations of the studied ionic liquids.