Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/37275 |
Resumo: | Pernicious effects of plastic particles, emergent contaminants worldwide, have been described in different species. In teleost species, alterations of immune function after exposure to nanoplastics (NPs) have been reported, but the interaction with cortisol - hypothalamic-pituitary-adrenal (HPI) axis has not yet been explored. Furthermore, the role of dissolved organic matter on the effects of NPs is poorly known. Thus, the aims of this research were to assess if polystyrene NPs (PSNPs) acted as a stressor on juvenile European seabass (Dicentrarchus labrax), interfering with the immune response, as well as to elucidate if humic acids (HA) modulated the potential effects of PSNPs. A short-term exposure to PSNPs and HA elicited an immuno-modulatory response, with an activation of steroidogenic stress-related pathways. An upregulation of anti-inflammatory cytokine (il10, tgfb) and stress-related (mc2r, gr1) transcripts were observed after exposure to HA and PSNPs both individually and in co-exposure. No notable alteration of inflammatory markers was consistently found, which may reflect a protective anti-inflammatory effect of HA in the presence of PSNPs. Nevertheless, there seems to be a more complex interaction between both components. Overall, data show that understanding the interaction of NPs with dissolved organic substances is key to deciphering their environmental risks. |
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Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax)Immune responseTransforming growth factor betaStress responseGlucocorticoid receptor 1Head kidneyPernicious effects of plastic particles, emergent contaminants worldwide, have been described in different species. In teleost species, alterations of immune function after exposure to nanoplastics (NPs) have been reported, but the interaction with cortisol - hypothalamic-pituitary-adrenal (HPI) axis has not yet been explored. Furthermore, the role of dissolved organic matter on the effects of NPs is poorly known. Thus, the aims of this research were to assess if polystyrene NPs (PSNPs) acted as a stressor on juvenile European seabass (Dicentrarchus labrax), interfering with the immune response, as well as to elucidate if humic acids (HA) modulated the potential effects of PSNPs. A short-term exposure to PSNPs and HA elicited an immuno-modulatory response, with an activation of steroidogenic stress-related pathways. An upregulation of anti-inflammatory cytokine (il10, tgfb) and stress-related (mc2r, gr1) transcripts were observed after exposure to HA and PSNPs both individually and in co-exposure. No notable alteration of inflammatory markers was consistently found, which may reflect a protective anti-inflammatory effect of HA in the presence of PSNPs. Nevertheless, there seems to be a more complex interaction between both components. Overall, data show that understanding the interaction of NPs with dissolved organic substances is key to deciphering their environmental risks.Elsevier2023-07-15T00:00:00Z2021-07-15T00:00:00Z2021-07-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37275eng0304-389410.1016/j.jhazmat.2021.125562Brandts, I.Balasch, J. C.Gonçalves, A. P.Martins, M. A.Pereira, M. L.Tvarijonaviciute, A.Teles, M.Oliveira, M.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:11:53Zoai:ria.ua.pt:10773/37275Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:53.259816Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
title |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
spellingShingle |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) Brandts, I. Immune response Transforming growth factor beta Stress response Glucocorticoid receptor 1 Head kidney |
title_short |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
title_full |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
title_fullStr |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
title_full_unstemmed |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
title_sort |
Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax) |
author |
Brandts, I. |
author_facet |
Brandts, I. Balasch, J. C. Gonçalves, A. P. Martins, M. A. Pereira, M. L. Tvarijonaviciute, A. Teles, M. Oliveira, M. |
author_role |
author |
author2 |
Balasch, J. C. Gonçalves, A. P. Martins, M. A. Pereira, M. L. Tvarijonaviciute, A. Teles, M. Oliveira, M. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Brandts, I. Balasch, J. C. Gonçalves, A. P. Martins, M. A. Pereira, M. L. Tvarijonaviciute, A. Teles, M. Oliveira, M. |
dc.subject.por.fl_str_mv |
Immune response Transforming growth factor beta Stress response Glucocorticoid receptor 1 Head kidney |
topic |
Immune response Transforming growth factor beta Stress response Glucocorticoid receptor 1 Head kidney |
description |
Pernicious effects of plastic particles, emergent contaminants worldwide, have been described in different species. In teleost species, alterations of immune function after exposure to nanoplastics (NPs) have been reported, but the interaction with cortisol - hypothalamic-pituitary-adrenal (HPI) axis has not yet been explored. Furthermore, the role of dissolved organic matter on the effects of NPs is poorly known. Thus, the aims of this research were to assess if polystyrene NPs (PSNPs) acted as a stressor on juvenile European seabass (Dicentrarchus labrax), interfering with the immune response, as well as to elucidate if humic acids (HA) modulated the potential effects of PSNPs. A short-term exposure to PSNPs and HA elicited an immuno-modulatory response, with an activation of steroidogenic stress-related pathways. An upregulation of anti-inflammatory cytokine (il10, tgfb) and stress-related (mc2r, gr1) transcripts were observed after exposure to HA and PSNPs both individually and in co-exposure. No notable alteration of inflammatory markers was consistently found, which may reflect a protective anti-inflammatory effect of HA in the presence of PSNPs. Nevertheless, there seems to be a more complex interaction between both components. Overall, data show that understanding the interaction of NPs with dissolved organic substances is key to deciphering their environmental risks. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-15T00:00:00Z 2021-07-15 2023-07-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/37275 |
url |
http://hdl.handle.net/10773/37275 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0304-3894 10.1016/j.jhazmat.2021.125562 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137732583227392 |