A review of conventional and emerging technologies for hydrogels sterilization

Detalhes bibliográficos
Autor(a) principal: S. A. Bento, Cristiana
Data de Publicação: 2023
Outros Autores: C. Gaspar, M., Coimbra, Patrícia, de Sousa, Hermínio C., E. M. Braga, Mara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/9199
Resumo: Funding This work was financially supported by Fundaçao ˜ para a Ciˆencia e Tecnologia (FCT), Portugal, through the project STERILAEROGEL – Green method to prepare sterilised biopolymer-based aerogel (POCI01–0145-FEDER-032625) and Strategic Projects FCT-MEC PEst-C/EQB/ UI0102/2019, UIDB/00102/2020 and Programmatic Project UIDP/ 00102/2020 of the CIEPQPF, and UI/05704/2020 of the ciTechCare. C. S. A. Bento acknowledges for PhD grant UI/BD/151008/2021 and M. C. Gaspar acknowledges FCT for the financial support under Scientific Employment Stimulus – Individual and Institutional Calls (CEECIND/ 00527/2017 and CEECINST/00060/2021).
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spelling A review of conventional and emerging technologies for hydrogels sterilizationHydrogelPolymersSterilizationAseptic processingBiomedical applicationsFunding This work was financially supported by Fundaçao ˜ para a Ciˆencia e Tecnologia (FCT), Portugal, through the project STERILAEROGEL – Green method to prepare sterilised biopolymer-based aerogel (POCI01–0145-FEDER-032625) and Strategic Projects FCT-MEC PEst-C/EQB/ UI0102/2019, UIDB/00102/2020 and Programmatic Project UIDP/ 00102/2020 of the CIEPQPF, and UI/05704/2020 of the ciTechCare. C. S. A. Bento acknowledges for PhD grant UI/BD/151008/2021 and M. C. Gaspar acknowledges FCT for the financial support under Scientific Employment Stimulus – Individual and Institutional Calls (CEECIND/ 00527/2017 and CEECINST/00060/2021).Hydrogels are extensively used in the biomedical field, as drug delivery systems, wound dressings, contact lenses or as scaffolds for tissue engineering. Due to their polymeric nature and the presence of high amounts of water in their structure, hydrogels generally present high sensitivity to terminal sterilization. The establishment of an efficient sterilization protocol that does not compromise the functional properties of the hydrogels is one of the challenges faced by researchers when developing a hydrogel for a specific application. Yet, until very recently this aspect was largely ignored in the literature. The present paper reviews the state of literature concerning hydrogels sterilization, compiling the main findings. Conventional terminal sterilization methods (heat sterilization, radiation sterilization, and gas sterilization) as well as emerging sterilization techniques (ozone, supercritical carbon dioxide) are covered. Considerations about aseptic processing are also included. Additionally, and as a framework, hydrogels’ polymeric materials, types of networks, and main biomedical applications are summarily described.ElsevierIC-OnlineS. A. Bento, CristianaC. Gaspar, M.Coimbra, Patríciade Sousa, Hermínio C.E. M. Braga, Mara2024-01-08T12:19:05Z2023-02-012023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/9199engCristiana S. A. Bento, Marisa C. Gaspar, Patrícia Coimbra, Hermínio C. de Sousa, Mara E. M. Braga, A review of conventional and emerging technologies for hydrogels sterilization, International Journal of Pharmaceutics, Volume 634, 2023, 122671, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2023.122671.0378-5173https://doi.org/10.1016/j.ijpharm.2023.122671info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:59:03Zoai:iconline.ipleiria.pt:10400.8/9199Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:46.232193Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A review of conventional and emerging technologies for hydrogels sterilization
title A review of conventional and emerging technologies for hydrogels sterilization
spellingShingle A review of conventional and emerging technologies for hydrogels sterilization
S. A. Bento, Cristiana
Hydrogel
Polymers
Sterilization
Aseptic processing
Biomedical applications
title_short A review of conventional and emerging technologies for hydrogels sterilization
title_full A review of conventional and emerging technologies for hydrogels sterilization
title_fullStr A review of conventional and emerging technologies for hydrogels sterilization
title_full_unstemmed A review of conventional and emerging technologies for hydrogels sterilization
title_sort A review of conventional and emerging technologies for hydrogels sterilization
author S. A. Bento, Cristiana
author_facet S. A. Bento, Cristiana
C. Gaspar, M.
Coimbra, Patrícia
de Sousa, Hermínio C.
E. M. Braga, Mara
author_role author
author2 C. Gaspar, M.
Coimbra, Patrícia
de Sousa, Hermínio C.
E. M. Braga, Mara
author2_role author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv S. A. Bento, Cristiana
C. Gaspar, M.
Coimbra, Patrícia
de Sousa, Hermínio C.
E. M. Braga, Mara
dc.subject.por.fl_str_mv Hydrogel
Polymers
Sterilization
Aseptic processing
Biomedical applications
topic Hydrogel
Polymers
Sterilization
Aseptic processing
Biomedical applications
description Funding This work was financially supported by Fundaçao ˜ para a Ciˆencia e Tecnologia (FCT), Portugal, through the project STERILAEROGEL – Green method to prepare sterilised biopolymer-based aerogel (POCI01–0145-FEDER-032625) and Strategic Projects FCT-MEC PEst-C/EQB/ UI0102/2019, UIDB/00102/2020 and Programmatic Project UIDP/ 00102/2020 of the CIEPQPF, and UI/05704/2020 of the ciTechCare. C. S. A. Bento acknowledges for PhD grant UI/BD/151008/2021 and M. C. Gaspar acknowledges FCT for the financial support under Scientific Employment Stimulus – Individual and Institutional Calls (CEECIND/ 00527/2017 and CEECINST/00060/2021).
publishDate 2023
dc.date.none.fl_str_mv 2023-02-01
2023-02-01T00:00:00Z
2024-01-08T12:19:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/9199
url http://hdl.handle.net/10400.8/9199
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cristiana S. A. Bento, Marisa C. Gaspar, Patrícia Coimbra, Hermínio C. de Sousa, Mara E. M. Braga, A review of conventional and emerging technologies for hydrogels sterilization, International Journal of Pharmaceutics, Volume 634, 2023, 122671, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2023.122671.
0378-5173
https://doi.org/10.1016/j.ijpharm.2023.122671
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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