Polyoxovanadates with emerging biomedical activities
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/17097 |
Resumo: | Polyoxovanadates (POVs) are a subclass of a larger family of polyanionic group V and VI metal-oxo clus ters that are known as polyoxometalates (POMs). POMs have been found to have antidiabetic, antibacte rial, antiprotozoal, antiviral and anticancer activities, which have sparked interest in their use as bioinorganic drugs. Among POVs, decavanadate ([V10O28] 6 ; V10) is an isopolyoxovanadate recently described to have several medicinal applications. In the present review, recent insights into POVs with emergent anticancer, antimicrobial and antiviral applications are described. Additionally, POVs’ stability and speciation under experimental biological conditions as well as POVs (in particular, V10) in vivo and ex vivo effects are highlighted. Finally, we report the most important 21st century studies of POVs’ effects and/or targets against cancer, bacteria and viruses including: apoptosis, cell cycle arrest, interference with ions transport system, inhibition of mRNA synthesis, cell morphology changes, changes in metabolic pathways, phosphorylase enzyme inhibition and cell signaling, formation of reactive oxygen species, lipid peroxidation, inhibition of viral mRNA polymerase, inhibition of virus binding to the host cell, penetra tion and interaction with virus protein cages. |
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Polyoxovanadates with emerging biomedical activitiesPolioxovanadates com atividades biomédicas emergentesPolyoxovanadatesPolyoxometalateDecavanadateVanadateMetal-oxides speciationAnticancer drugAntimicrobial drugAntiviral drugPolyoxovanadates (POVs) are a subclass of a larger family of polyanionic group V and VI metal-oxo clus ters that are known as polyoxometalates (POMs). POMs have been found to have antidiabetic, antibacte rial, antiprotozoal, antiviral and anticancer activities, which have sparked interest in their use as bioinorganic drugs. Among POVs, decavanadate ([V10O28] 6 ; V10) is an isopolyoxovanadate recently described to have several medicinal applications. In the present review, recent insights into POVs with emergent anticancer, antimicrobial and antiviral applications are described. Additionally, POVs’ stability and speciation under experimental biological conditions as well as POVs (in particular, V10) in vivo and ex vivo effects are highlighted. Finally, we report the most important 21st century studies of POVs’ effects and/or targets against cancer, bacteria and viruses including: apoptosis, cell cycle arrest, interference with ions transport system, inhibition of mRNA synthesis, cell morphology changes, changes in metabolic pathways, phosphorylase enzyme inhibition and cell signaling, formation of reactive oxygen species, lipid peroxidation, inhibition of viral mRNA polymerase, inhibition of virus binding to the host cell, penetra tion and interaction with virus protein cages.RASSR79857, FJC2019-039135-I, P33927, P33089ElsevierSapientiaAureliano, ManuelGumerova, Nadiia I.Sciortino, GiuseppeGarribba, EugenioRompel, AnnetteCrans, Debbie C.2021-09-14T08:29:46Z2021-112021-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/17097eng10.1016/j.ccr.2021.2141431873-3840info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:29:13Zoai:sapientia.ualg.pt:10400.1/17097Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:07:06.602985Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Polyoxovanadates with emerging biomedical activities Polioxovanadates com atividades biomédicas emergentes |
title |
Polyoxovanadates with emerging biomedical activities |
spellingShingle |
Polyoxovanadates with emerging biomedical activities Aureliano, Manuel Polyoxovanadates Polyoxometalate Decavanadate Vanadate Metal-oxides speciation Anticancer drug Antimicrobial drug Antiviral drug |
title_short |
Polyoxovanadates with emerging biomedical activities |
title_full |
Polyoxovanadates with emerging biomedical activities |
title_fullStr |
Polyoxovanadates with emerging biomedical activities |
title_full_unstemmed |
Polyoxovanadates with emerging biomedical activities |
title_sort |
Polyoxovanadates with emerging biomedical activities |
author |
Aureliano, Manuel |
author_facet |
Aureliano, Manuel Gumerova, Nadiia I. Sciortino, Giuseppe Garribba, Eugenio Rompel, Annette Crans, Debbie C. |
author_role |
author |
author2 |
Gumerova, Nadiia I. Sciortino, Giuseppe Garribba, Eugenio Rompel, Annette Crans, Debbie C. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Aureliano, Manuel Gumerova, Nadiia I. Sciortino, Giuseppe Garribba, Eugenio Rompel, Annette Crans, Debbie C. |
dc.subject.por.fl_str_mv |
Polyoxovanadates Polyoxometalate Decavanadate Vanadate Metal-oxides speciation Anticancer drug Antimicrobial drug Antiviral drug |
topic |
Polyoxovanadates Polyoxometalate Decavanadate Vanadate Metal-oxides speciation Anticancer drug Antimicrobial drug Antiviral drug |
description |
Polyoxovanadates (POVs) are a subclass of a larger family of polyanionic group V and VI metal-oxo clus ters that are known as polyoxometalates (POMs). POMs have been found to have antidiabetic, antibacte rial, antiprotozoal, antiviral and anticancer activities, which have sparked interest in their use as bioinorganic drugs. Among POVs, decavanadate ([V10O28] 6 ; V10) is an isopolyoxovanadate recently described to have several medicinal applications. In the present review, recent insights into POVs with emergent anticancer, antimicrobial and antiviral applications are described. Additionally, POVs’ stability and speciation under experimental biological conditions as well as POVs (in particular, V10) in vivo and ex vivo effects are highlighted. Finally, we report the most important 21st century studies of POVs’ effects and/or targets against cancer, bacteria and viruses including: apoptosis, cell cycle arrest, interference with ions transport system, inhibition of mRNA synthesis, cell morphology changes, changes in metabolic pathways, phosphorylase enzyme inhibition and cell signaling, formation of reactive oxygen species, lipid peroxidation, inhibition of viral mRNA polymerase, inhibition of virus binding to the host cell, penetra tion and interaction with virus protein cages. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-14T08:29:46Z 2021-11 2021-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/17097 |
url |
http://hdl.handle.net/10400.1/17097 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.ccr.2021.214143 1873-3840 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133315679125504 |