Superwarfarine Poisoning
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738 |
Resumo: | The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRON®) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long timeand there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response. |
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Superwarfarine PoisoningIntoxicação por SupervarfarinaBlood Coagulation DisordersRodenticides/poisoningVitamin K.CoagulopatiasRodenticidas/intoxicaçãoVitamina K.The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRON®) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long timeand there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response.Os raticidas do tipo supervarfarina são usados em todo o mundo e distinguem-se da varfarina pela sua elevada potência e duração de acção anticoagulante. O fácil acesso a este produto possibilita o seu uso no envenenamento humano acidental ou deliberado. É apresentado um caso clínico de intoxicação voluntária de raticida (RATIBRON®) por uma mulher que ingeriu uma quantidade total estimada de 27,5 mg de bromadiolona durante duas semanas, com manifestações hemorrágicas ligeiras, cuja reversão do efeito anticoagulante,com correcção do estudo da coagulação, demorou cerca de um mês. A correcção dos valores da hemostase é habitualmentedemorada e não existem orientações terapêuticas para estes casos, sendo que uma diminuição gradual das doses de vitamina K, em ambulatório, acompanhada do estudo do International Normalized Ratio, permite avaliar com segurança a resposta à terapêutica.Ordem dos Médicos2015-06-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegapplication/mswordapplication/mswordimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738oai:ojs.www.actamedicaportuguesa.com:article/5738Acta Médica Portuguesa; Vol. 28 No. 3 (2015): May-June; 389-392Acta Médica Portuguesa; Vol. 28 N.º 3 (2015): Maio-Junho; 389-3921646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/4352https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7356https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7515https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7516https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7517Freixo, AnaLopes, LuísCarvalho, ManuelaAraújo, Fernandoinfo:eu-repo/semantics/openAccess2022-12-20T11:04:27Zoai:ojs.www.actamedicaportuguesa.com:article/5738Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:09.281142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Superwarfarine Poisoning Intoxicação por Supervarfarina |
title |
Superwarfarine Poisoning |
spellingShingle |
Superwarfarine Poisoning Freixo, Ana Blood Coagulation Disorders Rodenticides/poisoning Vitamin K. Coagulopatias Rodenticidas/intoxicação Vitamina K. |
title_short |
Superwarfarine Poisoning |
title_full |
Superwarfarine Poisoning |
title_fullStr |
Superwarfarine Poisoning |
title_full_unstemmed |
Superwarfarine Poisoning |
title_sort |
Superwarfarine Poisoning |
author |
Freixo, Ana |
author_facet |
Freixo, Ana Lopes, Luís Carvalho, Manuela Araújo, Fernando |
author_role |
author |
author2 |
Lopes, Luís Carvalho, Manuela Araújo, Fernando |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Freixo, Ana Lopes, Luís Carvalho, Manuela Araújo, Fernando |
dc.subject.por.fl_str_mv |
Blood Coagulation Disorders Rodenticides/poisoning Vitamin K. Coagulopatias Rodenticidas/intoxicação Vitamina K. |
topic |
Blood Coagulation Disorders Rodenticides/poisoning Vitamin K. Coagulopatias Rodenticidas/intoxicação Vitamina K. |
description |
The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRON®) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long timeand there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-05 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738 oai:ojs.www.actamedicaportuguesa.com:article/5738 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738 |
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oai:ojs.www.actamedicaportuguesa.com:article/5738 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/4352 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7356 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7515 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7516 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7517 |
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openAccess |
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Ordem dos Médicos |
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Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 28 No. 3 (2015): May-June; 389-392 Acta Médica Portuguesa; Vol. 28 N.º 3 (2015): Maio-Junho; 389-392 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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