Superwarfarine Poisoning

Detalhes bibliográficos
Autor(a) principal: Freixo, Ana
Data de Publicação: 2015
Outros Autores: Lopes, Luís, Carvalho, Manuela, Araújo, Fernando
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738
Resumo: The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRON®) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long timeand there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response.
id RCAP_554c9c22c451963ed596bd636f4b908c
oai_identifier_str oai:ojs.www.actamedicaportuguesa.com:article/5738
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Superwarfarine PoisoningIntoxicação por SupervarfarinaBlood Coagulation DisordersRodenticides/poisoningVitamin K.CoagulopatiasRodenticidas/intoxicaçãoVitamina K.The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRON®) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long timeand there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response.Os raticidas do tipo supervarfarina são usados em todo o mundo e distinguem-se da varfarina pela sua elevada potência e duração de acção anticoagulante. O fácil acesso a este produto possibilita o seu uso no envenenamento humano acidental ou deliberado. É apresentado um caso clínico de intoxicação voluntária de raticida (RATIBRON®) por uma mulher que ingeriu uma quantidade total estimada de 27,5 mg de bromadiolona durante duas semanas, com manifestações hemorrágicas ligeiras, cuja reversão do efeito anticoagulante,com correcção do estudo da coagulação, demorou cerca de um mês. A correcção dos valores da hemostase é habitualmentedemorada e não existem orientações terapêuticas para estes casos, sendo que uma diminuição gradual das doses de vitamina K, em ambulatório, acompanhada do estudo do International Normalized Ratio, permite avaliar com segurança a resposta à terapêutica.Ordem dos Médicos2015-06-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegapplication/mswordapplication/mswordimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738oai:ojs.www.actamedicaportuguesa.com:article/5738Acta Médica Portuguesa; Vol. 28 No. 3 (2015): May-June; 389-392Acta Médica Portuguesa; Vol. 28 N.º 3 (2015): Maio-Junho; 389-3921646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/4352https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7356https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7515https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7516https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7517Freixo, AnaLopes, LuísCarvalho, ManuelaAraújo, Fernandoinfo:eu-repo/semantics/openAccess2022-12-20T11:04:27Zoai:ojs.www.actamedicaportuguesa.com:article/5738Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:09.281142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Superwarfarine Poisoning
Intoxicação por Supervarfarina
title Superwarfarine Poisoning
spellingShingle Superwarfarine Poisoning
Freixo, Ana
Blood Coagulation Disorders
Rodenticides/poisoning
Vitamin K.
Coagulopatias
Rodenticidas/intoxicação
Vitamina K.
title_short Superwarfarine Poisoning
title_full Superwarfarine Poisoning
title_fullStr Superwarfarine Poisoning
title_full_unstemmed Superwarfarine Poisoning
title_sort Superwarfarine Poisoning
author Freixo, Ana
author_facet Freixo, Ana
Lopes, Luís
Carvalho, Manuela
Araújo, Fernando
author_role author
author2 Lopes, Luís
Carvalho, Manuela
Araújo, Fernando
author2_role author
author
author
dc.contributor.author.fl_str_mv Freixo, Ana
Lopes, Luís
Carvalho, Manuela
Araújo, Fernando
dc.subject.por.fl_str_mv Blood Coagulation Disorders
Rodenticides/poisoning
Vitamin K.
Coagulopatias
Rodenticidas/intoxicação
Vitamina K.
topic Blood Coagulation Disorders
Rodenticides/poisoning
Vitamin K.
Coagulopatias
Rodenticidas/intoxicação
Vitamina K.
description The superwarfarin-type anticoagulant rodenticides are used throughout the world and distinguish themselves from warfarin for its high potency and long acting anticoagulant activity. Easy access to these products enables the accidental or deliberate human poisoning. A case of voluntary rodenticide poisoning (RATIBRON®) by a woman who ingested an estimated 27.5 mg of bromadiolone total quantity for two weeks, with minor bleeding episodes, whose reversal of the anticoagulant effect with the correction of the abnormal values of the clotting tests took about one month to reverse is reported here. The correction of the haemostasis defects takes usually a long timeand there are no treatment guidelines, but a gradually vitamin K dosage reduction, as out patients, along with the monitoring of the International Normalized Ratio levels, allows a safe evaluation of the therapeutic response.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-05
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738
oai:ojs.www.actamedicaportuguesa.com:article/5738
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/5738
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/4352
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7356
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7515
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7516
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5738/7517
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
image/jpeg
application/msword
application/msword
image/jpeg
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 28 No. 3 (2015): May-June; 389-392
Acta Médica Portuguesa; Vol. 28 N.º 3 (2015): Maio-Junho; 389-392
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130642378653696