Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

Detalhes bibliográficos
Autor(a) principal: Xavier, Joana M
Data de Publicação: 2015
Outros Autores: Davatchi, Fereydoun, Abade, Olga, Shahram, Farhad, Francisco, Vânia, Abdollahi, Bahar Sadeghi, Trindade, Hélder, Nadji, Abdolhadi, Shafiee, Niloofar Mojarad, Ghaderibarmi, Fahmida, Ligeiro, Dário, Oliveira, Sofia A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53195
Resumo: © 2015 Xavier et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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spelling Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran© 2015 Xavier et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Introduction: The aim of this study was to characterize the association of human leukocyte antigen (HLA) B alleles and major histocompatibility complex (MHC) single nucleotide polymorphisms (SNPs) with Behçet's disease (BD) in an Iranian dataset. Methods: The association of three SNPs in the MHC region previously identified as the most associated in high-density genotyping studies was tested in a case-control study on 973 BD patients and 825 controls from Iran, and the association of HLA-B alleles was tested in a subset of 681 patients and 414 controls. Results: We found that HLA-B*51 (P = 4.11 × 10(-41), OR [95% CI] = 4.63[3.66-5.85]) and B*15 confer risk for BD (P = 2.83 × 10(-2), OR [95% CI] = 1.75[1.08-2.84]) in Iranian, and in B*51 negative individuals, only the B*15 allele is significantly associated with BD (P = 2.51 × 10(-3), OR [95% CI] = 2.40[1.37-4.20]). rs76546355, formerly known as rs116799036, located between HLA-B and MICA (MHC class I polypeptide-related sequence A), demonstrated the same level of association with BD as HLA-B*51 (P adj = 1.78 × 10(-46), OR [95% CI] = 5.46[4.21-7.09], and P adj = 8.34 × 10(-48), OR [95% CI] = 5.44[4.20-7.05], respectively) in the HLA-B allelotyped subset, while rs2848713 was less associated (P adj = 7.14 × 10(-35), OR [95% CI] = 3.73[2.97-4.69]) and rs9260997 was not associated (P adj = 1.00 × 10(-1)). Additionally, we found that B*51 genotype-phenotype correlations do not survive Bonferroni correction, while carriers of the rs76546355 risk allele predominate in BD cases with genital ulcers, positive pathergy test and positive BD family history (2.31 × 10(-4) ≤ P ≤ 1.59 × 10(-3)). Conclusions: We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients.This work was supported by the Portuguese Fundação para a Ciência e a Tecnologia (grants PTDC/SAU-GMG/098937/2008, PTDC/IIM-GES/5015/2012 and CMUP-ERI/TPE/0028/2013, fellowships SFRH/BD/43895/2008 to JMX, SFRH/BPD/35737/2007 to PA, SFRH/BPD/70008/2010 to IS, a Ciência and an Investigator-FCT contract to SAO), and the Research Committee of the Tehran University of Medical Sciences (grant 132/714).Springer NatureRepositório da Universidade de LisboaXavier, Joana MDavatchi, FereydounAbade, OlgaShahram, FarhadFrancisco, VâniaAbdollahi, Bahar SadeghiTrindade, HélderNadji, AbdolhadiShafiee, Niloofar MojaradGhaderibarmi, FahmidaLigeiro, DárioOliveira, Sofia A2022-05-26T16:23:51Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53195engArthritis Res Ther. 2015 Mar 19;17(1):811478-635410.1186/s13075-015-0585-61478-6362info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:52Zoai:repositorio.ul.pt:10451/53195Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:09.646997Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
title Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
spellingShingle Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
Xavier, Joana M
title_short Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
title_full Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
title_fullStr Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
title_full_unstemmed Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
title_sort Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
author Xavier, Joana M
author_facet Xavier, Joana M
Davatchi, Fereydoun
Abade, Olga
Shahram, Farhad
Francisco, Vânia
Abdollahi, Bahar Sadeghi
Trindade, Hélder
Nadji, Abdolhadi
Shafiee, Niloofar Mojarad
Ghaderibarmi, Fahmida
Ligeiro, Dário
Oliveira, Sofia A
author_role author
author2 Davatchi, Fereydoun
Abade, Olga
Shahram, Farhad
Francisco, Vânia
Abdollahi, Bahar Sadeghi
Trindade, Hélder
Nadji, Abdolhadi
Shafiee, Niloofar Mojarad
Ghaderibarmi, Fahmida
Ligeiro, Dário
Oliveira, Sofia A
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Xavier, Joana M
Davatchi, Fereydoun
Abade, Olga
Shahram, Farhad
Francisco, Vânia
Abdollahi, Bahar Sadeghi
Trindade, Hélder
Nadji, Abdolhadi
Shafiee, Niloofar Mojarad
Ghaderibarmi, Fahmida
Ligeiro, Dário
Oliveira, Sofia A
description © 2015 Xavier et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-05-26T16:23:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53195
url http://hdl.handle.net/10451/53195
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arthritis Res Ther. 2015 Mar 19;17(1):81
1478-6354
10.1186/s13075-015-0585-6
1478-6362
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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