A hypometabolic defense strategy against malaria

• Autor(a) principal: Ramos, Susana
• Data de Publicação: 2022
• Outros Autores: Ademolue, Temitope W, Jentho, Elisa, Wu, Qian, Guerra, Joel, Martins, Rui, Pires, Gil, Weis, Sebastian, Carlos, Ana Rita, Mahú, Inês, Seixas, Elsa, Duarte, Denise, Rajas, Fabienne, Cardoso, Sílvia, Sousa, António G G, Lilue, Jingtao, Paixão, Tiago, Mithieux, Gilles, Nogueira, Fátima, Soares, Miguel P
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/142754
• topic: SDG 3 - Good Health and Well-being

Funding Information: We thank Dr. Silvia Portugal (Max Plank Institute, Berlin) and Dr. Jessica Thompson (Instituto Gulbenkian de Ciência; IGC) for their critical review of the manuscript; Dr. Joanne Thompson (University of Edinburgh) for PcAS-GFPML parasites; BEI Resources for P. falciparum parasites (MRA-1029, deposited by Andrew M. Talman and Robert E. Sinden); and excellent support from IGC's Advanced Imaging, Flow Cytometry & Antibody and Genomics facilities. S.R. was supported by Fundação Para a Ciência e Tecnologia (FCT; 5723/2014; FEDER029411); T.W.A. by the Gulbenkian foundation (IBB2017); E.J. by the Deutsche Forschungsgemeinschaft (DFG, EXC 2051; 390713860); A.R.C. by FCT (SFRH/BPD/101608/2014); S.W. and J.G. by the Center for Sepsis Control and Care (CSCC), Jena University Hospital (BMBF 01EO1502), and DFG (EXC 2051, 390713860, and WE 4971/6-1); and D.D. and F.N. by FCT (GHTM; UID/04413/2020). The M.P.S. laboratory is supported by the Gulbenkian, “La Caixa” (HR18-00502), and FCT (5723/2014; FEDER029411) foundations, as well as by the Oeiras-ERC Frontier Research Incentive Awards. M.P.S. is an associate member of the DFG Cluster of Excellence “Balance of the Microverse” (https://microverse-cluster.de/en). Support by Congento (LISBOA-01-0145-FEDER-022170) is acknowledged. Study design, experimental work, data analysis, and interpretation, S.R. and T.W.A.; Plasmodium scRNA data, E.J. (with S.R. and T.W.A.); in vitro experiments on heme regulation of gluconeogenesis, A.R.C. and Q.W.; indirect calorimetry measurements of heme-treated mice, J.G. and S.W.; flow cytometry experiments R.M. (with T.W.A.); Plasmodium virulence experiments, G.P. assisted S.R. and T.W.A.; experiments of induction of illness-induced anorexia in response to Plasmodium infection, I.M. and E.S. assisted S.R. and T.W.A.; maintenance and characterization of mouse strains; S.C.; bulk RNA and scRNA sequencing data analysis, A.G.G.S. and J.L. (with S.R. T.W.A. and E.J.); data interpretation, G.M. and F.R.; P. falciparum glucose tolerance in vitro experiments, F.N. (with S.R. and D.D.); formulation of the original hypothesis, study design, and writing of the manuscript, M.P.S. (with S.R. and T.W.A.). All authors read and approved the manuscript. The authors declare no competing interests. Funding Information: We thank Dr. Silvia Portugal (Max Plank Institute, Berlin) and Dr. Jessica Thompson (Instituto Gulbenkian de Ciência; IGC) for their critical review of the manuscript; Dr. Joanne Thompson (University of Edinburgh) for PcAS-GFP ML parasites; BEI Resources for P. falciparum parasites (MRA-1029, deposited by Andrew M. Talman and Robert E. Sinden); and excellent support from IGC’s Advanced Imaging, Flow Cytometry & Antibody and Genomics facilities. S.R. was supported by Fundação Para a Ciência e Tecnologia (FCT; 5723/2014 ; FEDER029411 ); T.W.A. by the Gulbenkian foundation ( IBB2017 ); E.J. by the Deutsche Forschungsgemeinschaft (DFG, EXC 2051 ; 390713860 ); A.R.C. by FCT ( SFRH/BPD/101608/2014 ); S.W. and J.G. by the Center for Sepsis Control and Care (CSCC), Jena University Hospital ( BMBF 01EO1502 ), and DFG ( EXC 2051 , 390713860 , and WE 4971/6-1 ); and D.D. and F.N. by FCT (GHTM; UID/04413/2020 ). The M.P.S. laboratory is supported by the Gulbenkian, “La Caixa” ( HR18-00502 ), and FCT ( 5723/2014 ; FEDER029411 ) foundations, as well as by the Oeiras-ERC Frontier Research Incentive Awards . M.P.S. is an associate member of the DFG Cluster of Excellence “Balance of the Microverse” ( https://microverse-cluster.de/en ). Support by Congento ( LISBOA-01-0145-FEDER-022170 ) is acknowledged. Publisher Copyright: © 2022 Elsevier Inc.