Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412 |
Resumo: | Brazil is one of the most diverse countries in the world when it comes to its plant species, with about 46,096 plants in more than nine different ecosystems, making it an indispensable area for research involving phytotherapy. Among the species that present therapeutic interests is Cannabis sativa L., which is a shrub from the Moraceae family that contains about 400 compounds, including more than 60 cannabinoids, the best known compounds of this group being tetrahydrocannabinol and cannabidiol. Thus, this study aims to investigate which phytochemical compounds are linked to the therapeutic properties of the species Cannabis sativa L. The active compounds, tetrahydrocannabinol, cannabidiol and pentacyclic triterpenes are responsible for various therapeutic activities, being mainly linked their mechanisms of action by the affinity to bind to G protein-coupled receptors, CB1 and CB2 present in the membranes of different human cells, having greater affinity for the CB1 receptor, being linked to psychoactive properties. It is believed that the effects of the action of cannabis compounds on the CB2 receptor may provide immunomodulatory effects, such as regulation of cytokine activity, as well as anti-inflammatory, antineoplastic, antimicrobial, analgesic, muscle relaxant, and antioxidant activities. Thus, the literature investigates that the phytochemical compounds, cannabidiol, tetrahydrocannabinol, and pentacyclic triterpenes are primarily responsible for the therapeutic properties of Cannabis sativa L.Keywords: Cannabis, phytochemical compounds, medicinal plants. |
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Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature reviewPropriedades terapêuticas dos compostos fitoquímicos da espécie Cannabis sativa L.: Uma revisão de literaturaBrazil is one of the most diverse countries in the world when it comes to its plant species, with about 46,096 plants in more than nine different ecosystems, making it an indispensable area for research involving phytotherapy. Among the species that present therapeutic interests is Cannabis sativa L., which is a shrub from the Moraceae family that contains about 400 compounds, including more than 60 cannabinoids, the best known compounds of this group being tetrahydrocannabinol and cannabidiol. Thus, this study aims to investigate which phytochemical compounds are linked to the therapeutic properties of the species Cannabis sativa L. The active compounds, tetrahydrocannabinol, cannabidiol and pentacyclic triterpenes are responsible for various therapeutic activities, being mainly linked their mechanisms of action by the affinity to bind to G protein-coupled receptors, CB1 and CB2 present in the membranes of different human cells, having greater affinity for the CB1 receptor, being linked to psychoactive properties. It is believed that the effects of the action of cannabis compounds on the CB2 receptor may provide immunomodulatory effects, such as regulation of cytokine activity, as well as anti-inflammatory, antineoplastic, antimicrobial, analgesic, muscle relaxant, and antioxidant activities. Thus, the literature investigates that the phytochemical compounds, cannabidiol, tetrahydrocannabinol, and pentacyclic triterpenes are primarily responsible for the therapeutic properties of Cannabis sativa L.Keywords: Cannabis, phytochemical compounds, medicinal plants.O Brasil é um dos países mais diversificados do mundo no que se refere às suas espécies vegetais, detém cerca de 46.096 plantas em mais de nove diferentes ecossistemas, sendo uma imprescindível área para pesquisas que envolvam a fitoterapia. Dentre as espécies de que apresentam interesses terapêuticos, está a Cannabis sativa L., que é um arbusto da família Moraceae que contém cerca de mais de 400 compostos, incluindo mais de 60 canabinóides, sendo os compostos mais conhecidos desse grupo o tetra-hidrocanabinol e o canabidiol. Assim, o presente estudo tem como objetivo investigar quais compostos fitoquímicos estão vinculados com as propriedades terapêuticas da espécie Cannabis sativa L. Os compostos ativos, tetra-hidrocanabinol, canabidiol e triterpenos pentacíclicos são responsáveis por diversas atividades terapêuticas, estando principalmente ligados seus mecanismos de ação pela afinidade em se ligar aos receptores acoplados à proteína G, CB1 e CB2 presentes nas membranas de diferentes células humanas, tendo maior afinidade para o receptor CB1, estando ligado às propriedades psicoativas. Acredita-se que os efeitos da ação dos compostos da Cannabis no receptor CB2 possam proporcionar efeitos imunomoduladores, como a regulação da atividade das citocinas, assim apresentado atividades anti-inflamatórias, antineoplásicas, antimicrobiana, analgésicas, relaxantes musculares e antioxidantes. Desse modo, a literatura investiga apresenta os compostos fitoquímicos, canabidiol, tetra-hidrocanabinol e triterpenos pentacíclicos são os principais responsáveis pelas propriedades terapêuticas da Cannabis sativa L.Palavras-chave: Cannabis, compostos fitoquímicos, plantas medicinais.Acta Farmacêutica Portuguesa2023-12-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412Acta Farmacêutica Portuguesa; v. 12 n. 2 (2023): Acta Farmacêutica Portuguesa 2023; 19-282182-3340reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412/310Torres, Sabrinada Silva, EllisonSilva, IranLima, JoãoSilva, Vitorinfo:eu-repo/semantics/openAccess2024-01-12T17:00:19Zoai:ojs.actafarmaceuticaportuguesa.com:article/412Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:30:17.882216Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review Propriedades terapêuticas dos compostos fitoquímicos da espécie Cannabis sativa L.: Uma revisão de literatura |
title |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review |
spellingShingle |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review Torres, Sabrina |
title_short |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review |
title_full |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review |
title_fullStr |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review |
title_full_unstemmed |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review |
title_sort |
Therapeutic properties of the phytochemical compounds of the species Cannabis sativa L.: A literature review |
author |
Torres, Sabrina |
author_facet |
Torres, Sabrina da Silva, Ellison Silva, Iran Lima, João Silva, Vitor |
author_role |
author |
author2 |
da Silva, Ellison Silva, Iran Lima, João Silva, Vitor |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Torres, Sabrina da Silva, Ellison Silva, Iran Lima, João Silva, Vitor |
description |
Brazil is one of the most diverse countries in the world when it comes to its plant species, with about 46,096 plants in more than nine different ecosystems, making it an indispensable area for research involving phytotherapy. Among the species that present therapeutic interests is Cannabis sativa L., which is a shrub from the Moraceae family that contains about 400 compounds, including more than 60 cannabinoids, the best known compounds of this group being tetrahydrocannabinol and cannabidiol. Thus, this study aims to investigate which phytochemical compounds are linked to the therapeutic properties of the species Cannabis sativa L. The active compounds, tetrahydrocannabinol, cannabidiol and pentacyclic triterpenes are responsible for various therapeutic activities, being mainly linked their mechanisms of action by the affinity to bind to G protein-coupled receptors, CB1 and CB2 present in the membranes of different human cells, having greater affinity for the CB1 receptor, being linked to psychoactive properties. It is believed that the effects of the action of cannabis compounds on the CB2 receptor may provide immunomodulatory effects, such as regulation of cytokine activity, as well as anti-inflammatory, antineoplastic, antimicrobial, analgesic, muscle relaxant, and antioxidant activities. Thus, the literature investigates that the phytochemical compounds, cannabidiol, tetrahydrocannabinol, and pentacyclic triterpenes are primarily responsible for the therapeutic properties of Cannabis sativa L.Keywords: Cannabis, phytochemical compounds, medicinal plants. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412 |
url |
https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412 https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/412/310 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Acta Farmacêutica Portuguesa |
publisher.none.fl_str_mv |
Acta Farmacêutica Portuguesa |
dc.source.none.fl_str_mv |
Acta Farmacêutica Portuguesa; v. 12 n. 2 (2023): Acta Farmacêutica Portuguesa 2023; 19-28 2182-3340 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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