Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy

Detalhes bibliográficos
Autor(a) principal: Escoli, R
Data de Publicação: 2015
Outros Autores: Santos, P, Andrade, S, Carvalho, F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2556
Resumo: Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms.
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spelling Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA NephropathyHCC NEFDabigatranGlomerulonephritis, IGADabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms.Hindawi Publishing CorporationRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEEscoli, RSantos, PAndrade, SCarvalho, F2016-08-12T12:28:33Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2556engCase Rep Nephrol. 2015;2015:29826110.1155/2015/298261info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:38:20Zoai:repositorio.chlc.min-saude.pt:10400.17/2556Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:54.312684Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
title Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
spellingShingle Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
Escoli, R
HCC NEF
Dabigatran
Glomerulonephritis, IGA
title_short Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
title_full Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
title_fullStr Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
title_full_unstemmed Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
title_sort Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
author Escoli, R
author_facet Escoli, R
Santos, P
Andrade, S
Carvalho, F
author_role author
author2 Santos, P
Andrade, S
Carvalho, F
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Escoli, R
Santos, P
Andrade, S
Carvalho, F
dc.subject.por.fl_str_mv HCC NEF
Dabigatran
Glomerulonephritis, IGA
topic HCC NEF
Dabigatran
Glomerulonephritis, IGA
description Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2016-08-12T12:28:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2556
url http://hdl.handle.net/10400.17/2556
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Case Rep Nephrol. 2015;2015:298261
10.1155/2015/298261
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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