Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/55465 |
Resumo: | © The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. When citing this article, a citation from any of the journals listed is appropriate. For commercial re-use, please contact journals.permissions@oup.com |
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Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation© The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. When citing this article, a citation from any of the journals listed is appropriate. For commercial re-use, please contact journals.permissions@oup.comRandomized controlled trials are the cornerstone for reliably evaluating therapeutic strategies. However, during the past 25 years, the rules and regulations governing randomized trials and their interpretation have become increasingly burdensome, and the cost and complexity of trials has become prohibitive. The present model is unsustainable, and the development of potentially effective treatments is often stopped prematurely on financial grounds, while existing drug treatments or non-drug interventions (such as screening strategies or management tools) may not be assessed reliably. The current ‘best regulatory practice’ environment, and a lack of consensus on what that requires, too often makes it unduly difficult to undertake efficient randomized trials able to provide reliable evidence about the safety and efficacy of potentially valuable interventions. Inclusion of underrepresented population groups and lack of diversity also remain among the challenges.Oxford University PressRepositório da Universidade de LisboaBowman, LouiseWeidinger, FranzAlbert, Michelle A.Fry, Edward T. A.Pinto, Fausto J.Achenbach, StephanBowman, LouiseCasadei, BarbaraCollins, RoryDevereaux, Philip J.Douglas, Pamela S.Frobert, OleGoto, ShinyaGrines, CindyHarrington, Robert A.Haynes, RichardHochman, Judith S.Charney, Leon H.James, StefanKirchhof, PaulusKomajda, MichelLam, Carolyn S. P.Landray, MartinMaggioni, AldoMcMurray, JohnMedhurst, NickMehran, RoxanaNeal, BruceRydén, LarsThiele, HolgerVan Gelder, IsabelleWallentin, LarsYusuf, SalimZannad, Faiez2022-12-20T15:37:58Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55465engEur Heart J. 2022 Dec 16;ehac6330195-668X10.1093/eurheartj/ehac6331522-9645info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:18:12Zoai:repositorio.ul.pt:10451/55465Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:18:12Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
title |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
spellingShingle |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation Bowman, Louise |
title_short |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
title_full |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
title_fullStr |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
title_full_unstemmed |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
title_sort |
Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation |
author |
Bowman, Louise |
author_facet |
Bowman, Louise Weidinger, Franz Albert, Michelle A. Fry, Edward T. A. Pinto, Fausto J. Achenbach, Stephan Casadei, Barbara Collins, Rory Devereaux, Philip J. Douglas, Pamela S. Frobert, Ole Goto, Shinya Grines, Cindy Harrington, Robert A. Haynes, Richard Hochman, Judith S. Charney, Leon H. James, Stefan Kirchhof, Paulus Komajda, Michel Lam, Carolyn S. P. Landray, Martin Maggioni, Aldo McMurray, John Medhurst, Nick Mehran, Roxana Neal, Bruce Rydén, Lars Thiele, Holger Van Gelder, Isabelle Wallentin, Lars Yusuf, Salim Zannad, Faiez |
author_role |
author |
author2 |
Weidinger, Franz Albert, Michelle A. Fry, Edward T. A. Pinto, Fausto J. Achenbach, Stephan Casadei, Barbara Collins, Rory Devereaux, Philip J. Douglas, Pamela S. Frobert, Ole Goto, Shinya Grines, Cindy Harrington, Robert A. Haynes, Richard Hochman, Judith S. Charney, Leon H. James, Stefan Kirchhof, Paulus Komajda, Michel Lam, Carolyn S. P. Landray, Martin Maggioni, Aldo McMurray, John Medhurst, Nick Mehran, Roxana Neal, Bruce Rydén, Lars Thiele, Holger Van Gelder, Isabelle Wallentin, Lars Yusuf, Salim Zannad, Faiez |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Bowman, Louise Weidinger, Franz Albert, Michelle A. Fry, Edward T. A. Pinto, Fausto J. Achenbach, Stephan Bowman, Louise Casadei, Barbara Collins, Rory Devereaux, Philip J. Douglas, Pamela S. Frobert, Ole Goto, Shinya Grines, Cindy Harrington, Robert A. Haynes, Richard Hochman, Judith S. Charney, Leon H. James, Stefan Kirchhof, Paulus Komajda, Michel Lam, Carolyn S. P. Landray, Martin Maggioni, Aldo McMurray, John Medhurst, Nick Mehran, Roxana Neal, Bruce Rydén, Lars Thiele, Holger Van Gelder, Isabelle Wallentin, Lars Yusuf, Salim Zannad, Faiez |
description |
© The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. When citing this article, a citation from any of the journals listed is appropriate. For commercial re-use, please contact journals.permissions@oup.com |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-20T15:37:58Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/55465 |
url |
http://hdl.handle.net/10451/55465 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Eur Heart J. 2022 Dec 16;ehac633 0195-668X 10.1093/eurheartj/ehac633 1522-9645 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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