Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation

Detalhes bibliográficos
Autor(a) principal: Bowman, Louise
Data de Publicação: 2022
Outros Autores: Weidinger, Franz, Albert, Michelle A., Fry, Edward T. A., Pinto, Fausto J., Achenbach, Stephan, Casadei, Barbara, Collins, Rory, Devereaux, Philip J., Douglas, Pamela S., Frobert, Ole, Goto, Shinya, Grines, Cindy, Harrington, Robert A., Haynes, Richard, Hochman, Judith S., Charney, Leon H., James, Stefan, Kirchhof, Paulus, Komajda, Michel, Lam, Carolyn S. P., Landray, Martin, Maggioni, Aldo, McMurray, John, Medhurst, Nick, Mehran, Roxana, Neal, Bruce, Rydén, Lars, Thiele, Holger, Van Gelder, Isabelle, Wallentin, Lars, Yusuf, Salim, Zannad, Faiez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55465
Resumo: © The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. When citing this article, a citation from any of the journals listed is appropriate. For commercial re-use, please contact journals.permissions@oup.com
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spelling Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation© The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. When citing this article, a citation from any of the journals listed is appropriate. For commercial re-use, please contact journals.permissions@oup.comRandomized controlled trials are the cornerstone for reliably evaluating therapeutic strategies. However, during the past 25 years, the rules and regulations governing randomized trials and their interpretation have become increasingly burdensome, and the cost and complexity of trials has become prohibitive. The present model is unsustainable, and the development of potentially effective treatments is often stopped prematurely on financial grounds, while existing drug treatments or non-drug interventions (such as screening strategies or management tools) may not be assessed reliably. The current ‘best regulatory practice’ environment, and a lack of consensus on what that requires, too often makes it unduly difficult to undertake efficient randomized trials able to provide reliable evidence about the safety and efficacy of potentially valuable interventions. Inclusion of underrepresented population groups and lack of diversity also remain among the challenges.Oxford University PressRepositório da Universidade de LisboaBowman, LouiseWeidinger, FranzAlbert, Michelle A.Fry, Edward T. A.Pinto, Fausto J.Achenbach, StephanBowman, LouiseCasadei, BarbaraCollins, RoryDevereaux, Philip J.Douglas, Pamela S.Frobert, OleGoto, ShinyaGrines, CindyHarrington, Robert A.Haynes, RichardHochman, Judith S.Charney, Leon H.James, StefanKirchhof, PaulusKomajda, MichelLam, Carolyn S. P.Landray, MartinMaggioni, AldoMcMurray, JohnMedhurst, NickMehran, RoxanaNeal, BruceRydén, LarsThiele, HolgerVan Gelder, IsabelleWallentin, LarsYusuf, SalimZannad, Faiez2022-12-20T15:37:58Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55465engEur Heart J. 2022 Dec 16;ehac6330195-668X10.1093/eurheartj/ehac6331522-9645info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:26Zoai:repositorio.ul.pt:10451/55465Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:06.778713Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
title Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
spellingShingle Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
Bowman, Louise
title_short Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
title_full Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
title_fullStr Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
title_full_unstemmed Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
title_sort Randomized trials fit for the 21st century. A joint opinion from the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation
author Bowman, Louise
author_facet Bowman, Louise
Weidinger, Franz
Albert, Michelle A.
Fry, Edward T. A.
Pinto, Fausto J.
Achenbach, Stephan
Casadei, Barbara
Collins, Rory
Devereaux, Philip J.
Douglas, Pamela S.
Frobert, Ole
Goto, Shinya
Grines, Cindy
Harrington, Robert A.
Haynes, Richard
Hochman, Judith S.
Charney, Leon H.
James, Stefan
Kirchhof, Paulus
Komajda, Michel
Lam, Carolyn S. P.
Landray, Martin
Maggioni, Aldo
McMurray, John
Medhurst, Nick
Mehran, Roxana
Neal, Bruce
Rydén, Lars
Thiele, Holger
Van Gelder, Isabelle
Wallentin, Lars
Yusuf, Salim
Zannad, Faiez
author_role author
author2 Weidinger, Franz
Albert, Michelle A.
Fry, Edward T. A.
Pinto, Fausto J.
Achenbach, Stephan
Casadei, Barbara
Collins, Rory
Devereaux, Philip J.
Douglas, Pamela S.
Frobert, Ole
Goto, Shinya
Grines, Cindy
Harrington, Robert A.
Haynes, Richard
Hochman, Judith S.
Charney, Leon H.
James, Stefan
Kirchhof, Paulus
Komajda, Michel
Lam, Carolyn S. P.
Landray, Martin
Maggioni, Aldo
McMurray, John
Medhurst, Nick
Mehran, Roxana
Neal, Bruce
Rydén, Lars
Thiele, Holger
Van Gelder, Isabelle
Wallentin, Lars
Yusuf, Salim
Zannad, Faiez
author2_role author
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author
author
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author
author
author
author
author
author
author
author
author
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author
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bowman, Louise
Weidinger, Franz
Albert, Michelle A.
Fry, Edward T. A.
Pinto, Fausto J.
Achenbach, Stephan
Bowman, Louise
Casadei, Barbara
Collins, Rory
Devereaux, Philip J.
Douglas, Pamela S.
Frobert, Ole
Goto, Shinya
Grines, Cindy
Harrington, Robert A.
Haynes, Richard
Hochman, Judith S.
Charney, Leon H.
James, Stefan
Kirchhof, Paulus
Komajda, Michel
Lam, Carolyn S. P.
Landray, Martin
Maggioni, Aldo
McMurray, John
Medhurst, Nick
Mehran, Roxana
Neal, Bruce
Rydén, Lars
Thiele, Holger
Van Gelder, Isabelle
Wallentin, Lars
Yusuf, Salim
Zannad, Faiez
description © The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. When citing this article, a citation from any of the journals listed is appropriate. For commercial re-use, please contact journals.permissions@oup.com
publishDate 2022
dc.date.none.fl_str_mv 2022-12-20T15:37:58Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.relation.none.fl_str_mv Eur Heart J. 2022 Dec 16;ehac633
0195-668X
10.1093/eurheartj/ehac633
1522-9645
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dc.publisher.none.fl_str_mv Oxford University Press
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