Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/136260 |
Resumo: | European populations display low genetic differentiation as the result of long-term blending of their ancient founding ancestries. However, it is unclear how the combination of ancient ancestries related to early foragers, Neolithic farmers, and Bronze Age nomadic pastoralists can explain the distribution of genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the continental diversity, but have been systematically understudied. Here, we characterize the ancestry profiles of Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe, and the rest of the world. Italian genomes capture several ancient signatures, including a non-steppe contribution derived ultimately from the Caucasus. Differences in ancestry composition, as the result of migration and admixture, have generated in Italy the largest degree of population structure detected so far in the continent, as well as shaping the amount of Neanderthal DNA in modern-day populations. |
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Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern EuropeEuropean populations display low genetic differentiation as the result of long-term blending of their ancient founding ancestries. However, it is unclear how the combination of ancient ancestries related to early foragers, Neolithic farmers, and Bronze Age nomadic pastoralists can explain the distribution of genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the continental diversity, but have been systematically understudied. Here, we characterize the ancestry profiles of Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe, and the rest of the world. Italian genomes capture several ancient signatures, including a non-steppe contribution derived ultimately from the Caucasus. Differences in ancestry composition, as the result of migration and admixture, have generated in Italy the largest degree of population structure detected so far in the continent, as well as shaping the amount of Neanderthal DNA in modern-day populations.American Association for the Advancement of Science20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/136260eng2375-254810.1126/sciadv.aaw3492Raveane, AAneli, SMontinaro, FAthanasiadis, GBarlera, SBirolo, GBoncoraglio, GDi, Blasio, AMDi, Gaetano, CPagani, LParolo, SPaschou, PPiazza, AStamatoyannopoulos, GAngius, ABrucato, NCucca, FHellenthal, GMulas, APeyret-Guzzon, MZoledziewska, MBaali, ABycroft, CCherkaoui, MChiaroni, JDi, Cristofaro, JDina, CDugoujon, JMGalan, PGiemza, JKivisild, TMazieres, SMelhaoui, MMetspalu, MMyers, SPereira, LRicaut, FXBrisighelli, FCardinali, IGrugni, VLancioni, HPascali, VLTorroni, ASemino, OMatullo, GAchilli, AOlivieri, ACapelli, Cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:04:43Zoai:repositorio-aberto.up.pt:10216/136260Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:15:07.711598Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
title |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
spellingShingle |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe Raveane, A |
title_short |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
title_full |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
title_fullStr |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
title_full_unstemmed |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
title_sort |
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe |
author |
Raveane, A |
author_facet |
Raveane, A Aneli, S Montinaro, F Athanasiadis, G Barlera, S Birolo, G Boncoraglio, G Di, Blasio, AM Di, Gaetano, C Pagani, L Parolo, S Paschou, P Piazza, A Stamatoyannopoulos, G Angius, A Brucato, N Cucca, F Hellenthal, G Mulas, A Peyret-Guzzon, M Zoledziewska, M Baali, A Bycroft, C Cherkaoui, M Chiaroni, J Di, Cristofaro, J Dina, C Dugoujon, JM Galan, P Giemza, J Kivisild, T Mazieres, S Melhaoui, M Metspalu, M Myers, S Pereira, L Ricaut, FX Brisighelli, F Cardinali, I Grugni, V Lancioni, H Pascali, VL Torroni, A Semino, O Matullo, G Achilli, A Olivieri, A Capelli, C |
author_role |
author |
author2 |
Aneli, S Montinaro, F Athanasiadis, G Barlera, S Birolo, G Boncoraglio, G Di, Blasio, AM Di, Gaetano, C Pagani, L Parolo, S Paschou, P Piazza, A Stamatoyannopoulos, G Angius, A Brucato, N Cucca, F Hellenthal, G Mulas, A Peyret-Guzzon, M Zoledziewska, M Baali, A Bycroft, C Cherkaoui, M Chiaroni, J Di, Cristofaro, J Dina, C Dugoujon, JM Galan, P Giemza, J Kivisild, T Mazieres, S Melhaoui, M Metspalu, M Myers, S Pereira, L Ricaut, FX Brisighelli, F Cardinali, I Grugni, V Lancioni, H Pascali, VL Torroni, A Semino, O Matullo, G Achilli, A Olivieri, A Capelli, C |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Raveane, A Aneli, S Montinaro, F Athanasiadis, G Barlera, S Birolo, G Boncoraglio, G Di, Blasio, AM Di, Gaetano, C Pagani, L Parolo, S Paschou, P Piazza, A Stamatoyannopoulos, G Angius, A Brucato, N Cucca, F Hellenthal, G Mulas, A Peyret-Guzzon, M Zoledziewska, M Baali, A Bycroft, C Cherkaoui, M Chiaroni, J Di, Cristofaro, J Dina, C Dugoujon, JM Galan, P Giemza, J Kivisild, T Mazieres, S Melhaoui, M Metspalu, M Myers, S Pereira, L Ricaut, FX Brisighelli, F Cardinali, I Grugni, V Lancioni, H Pascali, VL Torroni, A Semino, O Matullo, G Achilli, A Olivieri, A Capelli, C |
description |
European populations display low genetic differentiation as the result of long-term blending of their ancient founding ancestries. However, it is unclear how the combination of ancient ancestries related to early foragers, Neolithic farmers, and Bronze Age nomadic pastoralists can explain the distribution of genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the continental diversity, but have been systematically understudied. Here, we characterize the ancestry profiles of Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe, and the rest of the world. Italian genomes capture several ancient signatures, including a non-steppe contribution derived ultimately from the Caucasus. Differences in ancestry composition, as the result of migration and admixture, have generated in Italy the largest degree of population structure detected so far in the continent, as well as shaping the amount of Neanderthal DNA in modern-day populations. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/136260 |
url |
https://hdl.handle.net/10216/136260 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2375-2548 10.1126/sciadv.aaw3492 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
publisher.none.fl_str_mv |
American Association for the Advancement of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136072125382656 |