A minimal HIV-AIDS infection model with general incidence rate and application to Morocco data

• Autor(a) principal: Lotfi, El Mehdi
• Data de Publicação: 2019
• Outros Autores: Mahrouf, Marouane, Maziane, Mehdi, Silva, Cristiana J., Torres, Delfim F. M., Yousfi, Noura
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10773/26476
• topic: SICA compartmental model; General incidence function; Global stability; Lyapunov functionals

We study the global dynamics of a SICA infection model with general incidence rate. The proposed model is calibrated with cumulative cases of infection by HIV–AIDS in Morocco from 1986 to 2015. We first prove that our model is biologically and mathematically well-posed. Stability analysis of different steady states is performed and threshold parameters are identified where the model exhibits clearance of infection or maintenance of a chronic infection. Furthermore, we examine the robustness of the model to some parameter values by examining the sensitivity of the basic reproduction number. Finally, using numerical simulations with real data from Morocco, we show that the model predicts well such reality.