3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/73934 |
Resumo: | Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures. In contrast, 3D bioprinting, an evolving biofabrication method, focuses on the accurate deposition of hydrogel bioinks loaded with cells to construct tissue-engineered structures. The purpose of the present work is to conduct a systematic review (SR) of the published literature, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, providing a source of information on the evolution of organ-on-a-chip platforms obtained resorting to 3D printing and bioprinting techniques. In the literature search, PubMed, Scopus, and ScienceDirect databases were used, and two authors independently performed the search, study selection, and data extraction. The goal of this SR is to highlight the importance and advantages of using 3D printing techniques in obtaining organ-on-a-chip platforms, and also to identify potential gaps and future perspectives in this research field. Additionally, challenges in integrating sensors in organs-on-chip platforms are briefly investigated and discussed. |
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3D printing techniques and their applications to organ-on-a-chip platforms: a systematic reviewBiofabricationOrgan-on-a-chip3D bioprintingIn vitro modelsBiosensorsBiomicrofluidicsScience & TechnologyThree-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures. In contrast, 3D bioprinting, an evolving biofabrication method, focuses on the accurate deposition of hydrogel bioinks loaded with cells to construct tissue-engineered structures. The purpose of the present work is to conduct a systematic review (SR) of the published literature, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, providing a source of information on the evolution of organ-on-a-chip platforms obtained resorting to 3D printing and bioprinting techniques. In the literature search, PubMed, Scopus, and ScienceDirect databases were used, and two authors independently performed the search, study selection, and data extraction. The goal of this SR is to highlight the importance and advantages of using 3D printing techniques in obtaining organ-on-a-chip platforms, and also to identify potential gaps and future perspectives in this research field. Additionally, challenges in integrating sensors in organs-on-chip platforms are briefly investigated and discussed.The authors are grateful for the funding of FCT through the projects NORTE-01-0145- FEDER-029394, NORTE-01-0145-FEDER-030171 funded by COMPETE2020, NORTE2020, PORTUGAL2020, and FEDER. This work was also supported by Fundação para a Ciência e a Tecnologia (FCT) under the strategic grants UIDB/04077/2020, UIDB/00319/2020, UIDB/04436/2020 and UIDB/00532/2020. This work was also funded by AMED-CREST Grant Number JP20gm1310001h0002.Violeta Carvalho acknowledges the PhD scholarship UI/BD/151028/2021 attributed by FCT. Inês Gonçalves acknowledges the PhD scholarship BD/08646/2020 attributed by FCT.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoCarvalho, Violeta MenesesGonçalves, Inês Maia Silva RodrigoLage, Teresa Cristina CarqueijóRodrigues, Raquel OliveiraMinas, GraçaTeixeira, S. F. C. F.Moita, Ana S.Hori, TakeshiKaji, HirokazuLima, Rui Alberto Madeira Macedo2021-05-102021-05-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73934engCarvalho, V.; Gonçalves, I.; Lage, T.; Rodrigues, R.O.; Minas, G.; Teixeira, S.F.C.F.; Moita, A.S.; Hori, T.; Kaji, H.; Lima, R.A. 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review. Sensors 2021, 21, 3304. https://doi.org/10.3390/s210933041424-82201424-822010.3390/s2109330434068811https://www.mdpi.com/1424-8220/21/9/3304info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:29:32Zoai:repositorium.sdum.uminho.pt:1822/73934Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:24:32.111112Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
title |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
spellingShingle |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review Carvalho, Violeta Meneses Biofabrication Organ-on-a-chip 3D bioprinting In vitro models Biosensors Biomicrofluidics Science & Technology |
title_short |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
title_full |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
title_fullStr |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
title_full_unstemmed |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
title_sort |
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
author |
Carvalho, Violeta Meneses |
author_facet |
Carvalho, Violeta Meneses Gonçalves, Inês Maia Silva Rodrigo Lage, Teresa Cristina Carqueijó Rodrigues, Raquel Oliveira Minas, Graça Teixeira, S. F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui Alberto Madeira Macedo |
author_role |
author |
author2 |
Gonçalves, Inês Maia Silva Rodrigo Lage, Teresa Cristina Carqueijó Rodrigues, Raquel Oliveira Minas, Graça Teixeira, S. F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui Alberto Madeira Macedo |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Carvalho, Violeta Meneses Gonçalves, Inês Maia Silva Rodrigo Lage, Teresa Cristina Carqueijó Rodrigues, Raquel Oliveira Minas, Graça Teixeira, S. F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui Alberto Madeira Macedo |
dc.subject.por.fl_str_mv |
Biofabrication Organ-on-a-chip 3D bioprinting In vitro models Biosensors Biomicrofluidics Science & Technology |
topic |
Biofabrication Organ-on-a-chip 3D bioprinting In vitro models Biosensors Biomicrofluidics Science & Technology |
description |
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures. In contrast, 3D bioprinting, an evolving biofabrication method, focuses on the accurate deposition of hydrogel bioinks loaded with cells to construct tissue-engineered structures. The purpose of the present work is to conduct a systematic review (SR) of the published literature, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, providing a source of information on the evolution of organ-on-a-chip platforms obtained resorting to 3D printing and bioprinting techniques. In the literature search, PubMed, Scopus, and ScienceDirect databases were used, and two authors independently performed the search, study selection, and data extraction. The goal of this SR is to highlight the importance and advantages of using 3D printing techniques in obtaining organ-on-a-chip platforms, and also to identify potential gaps and future perspectives in this research field. Additionally, challenges in integrating sensors in organs-on-chip platforms are briefly investigated and discussed. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-10 2021-05-10T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73934 |
url |
http://hdl.handle.net/1822/73934 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carvalho, V.; Gonçalves, I.; Lage, T.; Rodrigues, R.O.; Minas, G.; Teixeira, S.F.C.F.; Moita, A.S.; Hori, T.; Kaji, H.; Lima, R.A. 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review. Sensors 2021, 21, 3304. https://doi.org/10.3390/s21093304 1424-8220 1424-8220 10.3390/s21093304 34068811 https://www.mdpi.com/1424-8220/21/9/3304 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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