Chronic unpredictable stress inhibits nociception in male rats
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/1686 |
Resumo: | Chronic stress elicits remarkable alterations to the structure and function of several areas of the central nervous system. Nociception is known to be affected by chronic stress and age, although the observations are contradictory. Herein we report that both young and old rats submitted to a chronic unpredictable stress paradigm have reduced nociception in the tail-flick nociceptive test. Moreover, stressed animals show an increase in nociceptive threshold after three successive exposures to noxious stimulation (within a 2 min interval). While the sustained stress-induced analgesia is usually attributed to the resulting hypercorticalism, the immediate exacerbation of tolerance to pain displayed by stressed animals is most likely mediated through other mechanisms due to the very rapid antinociceptive effect observed. |
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Chronic unpredictable stress inhibits nociception in male ratsRatChronic unpredictable stressPain toleranceTail-flickAntinociceptionScience & TechnologyChronic stress elicits remarkable alterations to the structure and function of several areas of the central nervous system. Nociception is known to be affected by chronic stress and age, although the observations are contradictory. Herein we report that both young and old rats submitted to a chronic unpredictable stress paradigm have reduced nociception in the tail-flick nociceptive test. Moreover, stressed animals show an increase in nociceptive threshold after three successive exposures to noxious stimulation (within a 2 min interval). While the sustained stress-induced analgesia is usually attributed to the resulting hypercorticalism, the immediate exacerbation of tolerance to pain displayed by stressed animals is most likely mediated through other mechanisms due to the very rapid antinociceptive effect observed.Fundação para a Ciência e a Tecnologia (FCT) – Programa Operacional “Ciência, Tecnologia, Inovação” (POCTI), União Europeia (UE). Fundo Europeu de Desenvolvimento Regional (FEDER) - POCTI/NSE/46399/2002.Grunenthal Foundation.ElsevierUniversidade do MinhoRibeiro, Filipa PintoAlmeida, ArmandoPêgo, José M.Cerqueira, JoãoSousa, Nuno20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/1686eng"Neuroscience letters". ISSN 0304-3940. 359 (2004) 73–76.0304-394010.1016/j.neulet.2004.02.01615050715http://www.elsevier.com/wps/find/homepage.cws_homeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:03Zoai:repositorium.sdum.uminho.pt:1822/1686Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:52.553661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chronic unpredictable stress inhibits nociception in male rats |
title |
Chronic unpredictable stress inhibits nociception in male rats |
spellingShingle |
Chronic unpredictable stress inhibits nociception in male rats Ribeiro, Filipa Pinto Rat Chronic unpredictable stress Pain tolerance Tail-flick Antinociception Science & Technology |
title_short |
Chronic unpredictable stress inhibits nociception in male rats |
title_full |
Chronic unpredictable stress inhibits nociception in male rats |
title_fullStr |
Chronic unpredictable stress inhibits nociception in male rats |
title_full_unstemmed |
Chronic unpredictable stress inhibits nociception in male rats |
title_sort |
Chronic unpredictable stress inhibits nociception in male rats |
author |
Ribeiro, Filipa Pinto |
author_facet |
Ribeiro, Filipa Pinto Almeida, Armando Pêgo, José M. Cerqueira, João Sousa, Nuno |
author_role |
author |
author2 |
Almeida, Armando Pêgo, José M. Cerqueira, João Sousa, Nuno |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ribeiro, Filipa Pinto Almeida, Armando Pêgo, José M. Cerqueira, João Sousa, Nuno |
dc.subject.por.fl_str_mv |
Rat Chronic unpredictable stress Pain tolerance Tail-flick Antinociception Science & Technology |
topic |
Rat Chronic unpredictable stress Pain tolerance Tail-flick Antinociception Science & Technology |
description |
Chronic stress elicits remarkable alterations to the structure and function of several areas of the central nervous system. Nociception is known to be affected by chronic stress and age, although the observations are contradictory. Herein we report that both young and old rats submitted to a chronic unpredictable stress paradigm have reduced nociception in the tail-flick nociceptive test. Moreover, stressed animals show an increase in nociceptive threshold after three successive exposures to noxious stimulation (within a 2 min interval). While the sustained stress-induced analgesia is usually attributed to the resulting hypercorticalism, the immediate exacerbation of tolerance to pain displayed by stressed animals is most likely mediated through other mechanisms due to the very rapid antinociceptive effect observed. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 2004-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/1686 |
url |
http://hdl.handle.net/1822/1686 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Neuroscience letters". ISSN 0304-3940. 359 (2004) 73–76. 0304-3940 10.1016/j.neulet.2004.02.016 15050715 http://www.elsevier.com/wps/find/homepage.cws_home |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133081876037632 |