PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.70.2.29 |
Resumo: | Introduction: Pyoderma gangrenosum (PG) is an idiopathic, recurrent, neutrophilic and ulcerative skin disease. Case report: A 43-year-old man with chronic hepatitis C and drugs addiction in the past presented with a 6-months history of painful, violaceus, suppurative and necrotic ulcers on his lower extremities and any skin area inju- red by needle stick. PG was the main diagnosis proposed. Histological examination of the lesion edge demonstrated microscopic changes compatible with PG. Laboratory and radiological evaluation findings were compatible with his chronic liver disease. The patient was treated, in different moments, with systemic steroids, cyclosporine, dapsone, and thalidomide, with no satisfactory response. A complete remission was achieved with etanercept. Twelve months later, there were no signals of skin lesions, relevant hepatic damages or increase in viral load. Conclusion: Etanercept was a safe and effective therapeutic option.KEYWORDS – Pyoderma Gangrenosum; Hepatitis C, Chronic; Thalidomide; Glucocorticoids; Receptors, Tumor Necro- sis Factor; Immunoglobulin G. |
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PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPTPIODERMA GANGRENOSO ASSOCIADO A HEPATITE C CRÓNICA TRATADO EFICAZMENTE COM ETANERCEPTIntroduction: Pyoderma gangrenosum (PG) is an idiopathic, recurrent, neutrophilic and ulcerative skin disease. Case report: A 43-year-old man with chronic hepatitis C and drugs addiction in the past presented with a 6-months history of painful, violaceus, suppurative and necrotic ulcers on his lower extremities and any skin area inju- red by needle stick. PG was the main diagnosis proposed. Histological examination of the lesion edge demonstrated microscopic changes compatible with PG. Laboratory and radiological evaluation findings were compatible with his chronic liver disease. The patient was treated, in different moments, with systemic steroids, cyclosporine, dapsone, and thalidomide, with no satisfactory response. A complete remission was achieved with etanercept. Twelve months later, there were no signals of skin lesions, relevant hepatic damages or increase in viral load. Conclusion: Etanercept was a safe and effective therapeutic option.KEYWORDS – Pyoderma Gangrenosum; Hepatitis C, Chronic; Thalidomide; Glucocorticoids; Receptors, Tumor Necro- sis Factor; Immunoglobulin G.Introdução: O pioderma gangrenoso (PG) é uma dermatose neutrofílica, ulcerativa, recorrente e de etio-patogenia desconhecida. Caso clínico: Homem, de 43 anos, ex-toxicodependente e portador de hepatite C crónica, observado por quadro clínico com 6 meses de evolução, caracterizado por úlceras dolorosas, de fundo supurativo e necrótico, localizadas nos membros inferiores e em áreas de picadas por agulha. Colocou-se como principal hipótese de diagnóstico o PG, tendo o exame histológico do bordo da lesão demonstrado alterações compatíveis com o mesmo. A avaliação imagiológica e laboratorial evidenciou apenas alterações relacionadas com a doença hepática crónica. Foi submetido, em momentos diferentes, a tratamentos com corticóides sistémicos, ciclosporina, dapsona e talidomida, sem resposta satisfatória. Após introdução do etanercept, verificou-se remissão completa do quadro. Doze meses após introdução do anti-TNF-α, o doente encontra-se sem lesões cutâneas, alterações hepáticas relevan- tes ou elevação da carga viral. Conclusão: O etanercept mostrou-se ser uma alternativa eficaz e segura.PALAVRAS-CHAVE – Pioderma Gangrenoso; Hepatite C Crónica; Talidomida; Corticóides; Etanercept.Sociedade Portuguesa de Dermatologia e Venereologia2013-01-17T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.70.2.29oai:ojs.revista.spdv.com.pt:article/29Journal of the Portuguese Society of Dermatology and Venereology; Vol 70 No 2 (2012): Abril - Junho; 215Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 70 n. 2 (2012): Abril - Junho; 2152182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/29https://doi.org/10.29021/spdv.70.2.29https://revista.spdv.com.pt/index.php/spdv/article/view/29/29Tavares, ErmelindoDores, José AlbertoAranha, Joãoinfo:eu-repo/semantics/openAccess2022-10-06T12:34:36Zoai:ojs.revista.spdv.com.pt:article/29Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:38.066397Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT PIODERMA GANGRENOSO ASSOCIADO A HEPATITE C CRÓNICA TRATADO EFICAZMENTE COM ETANERCEPT |
title |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT |
spellingShingle |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT Tavares, Ermelindo |
title_short |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT |
title_full |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT |
title_fullStr |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT |
title_full_unstemmed |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT |
title_sort |
PYODERMA GANGRENOSUM ASSOCIATED WITH CHRONIC HEPATITIS C SUCCESSFULLY TREATED WITH ETANERCEPT |
author |
Tavares, Ermelindo |
author_facet |
Tavares, Ermelindo Dores, José Alberto Aranha, João |
author_role |
author |
author2 |
Dores, José Alberto Aranha, João |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Tavares, Ermelindo Dores, José Alberto Aranha, João |
description |
Introduction: Pyoderma gangrenosum (PG) is an idiopathic, recurrent, neutrophilic and ulcerative skin disease. Case report: A 43-year-old man with chronic hepatitis C and drugs addiction in the past presented with a 6-months history of painful, violaceus, suppurative and necrotic ulcers on his lower extremities and any skin area inju- red by needle stick. PG was the main diagnosis proposed. Histological examination of the lesion edge demonstrated microscopic changes compatible with PG. Laboratory and radiological evaluation findings were compatible with his chronic liver disease. The patient was treated, in different moments, with systemic steroids, cyclosporine, dapsone, and thalidomide, with no satisfactory response. A complete remission was achieved with etanercept. Twelve months later, there were no signals of skin lesions, relevant hepatic damages or increase in viral load. Conclusion: Etanercept was a safe and effective therapeutic option.KEYWORDS – Pyoderma Gangrenosum; Hepatitis C, Chronic; Thalidomide; Glucocorticoids; Receptors, Tumor Necro- sis Factor; Immunoglobulin G. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-17T00:00:00Z |
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journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.70.2.29 oai:ojs.revista.spdv.com.pt:article/29 |
url |
https://doi.org/10.29021/spdv.70.2.29 |
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oai:ojs.revista.spdv.com.pt:article/29 |
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por |
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dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/29 https://doi.org/10.29021/spdv.70.2.29 https://revista.spdv.com.pt/index.php/spdv/article/view/29/29 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Sociedade Portuguesa de Dermatologia e Venereologia |
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Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 70 No 2 (2012): Abril - Junho; 215 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 70 n. 2 (2012): Abril - Junho; 215 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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