Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.11/8743 |
Resumo: | Hepatitis E virus (HEV) is a zoonotic foodborne virus with an annual infection prevalence of 20 million human cases, which seriously affects public health and economic development in both developed and developing countries. To better understand the epidemiology of HEV in Central Portugal, a cross-sectional study was conducted from 2016 to 2023 with sera samples from wild ungulates. The seroprevalence and risk factors for HEV seropositivity were evaluated in the present study. Specifically, antibodies against HEV were determined by a commercial enzyme-linked immunesorbent assay (ELISA). Our results show that in the 650 sera samples collected from 298 wild red deer and 352 wild boars in Portugal, 9.1% red deer and 1.7% wild boar were positive for antibodies to HEV. Regarding age, the seropositivity in juvenile wild ungulates was 1.3%, whereas it was 7.2% in adults. Logistic regression models investigated risk factors for seropositivity. The odds of being seropositive was 3.6 times higher in adults than in juveniles, and the risk was 4.2 times higher in red deer than in wild boar. Both wild ungulate species were exposed to HEV. The higher seroprevalence in red deer suggests that this species may make a major contribution to the ecology of HEV in Central Portugal. Further research is needed to understand how wildlife affects the epidemiology of HEV infections in Portugal. |
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Prevalence and risk factors for hepatitis E virus in wild boar and red deer in PortugalELISAHepatitis E virusPortugalRed deerRisk factorsWild boarHepatitis E virus (HEV) is a zoonotic foodborne virus with an annual infection prevalence of 20 million human cases, which seriously affects public health and economic development in both developed and developing countries. To better understand the epidemiology of HEV in Central Portugal, a cross-sectional study was conducted from 2016 to 2023 with sera samples from wild ungulates. The seroprevalence and risk factors for HEV seropositivity were evaluated in the present study. Specifically, antibodies against HEV were determined by a commercial enzyme-linked immunesorbent assay (ELISA). Our results show that in the 650 sera samples collected from 298 wild red deer and 352 wild boars in Portugal, 9.1% red deer and 1.7% wild boar were positive for antibodies to HEV. Regarding age, the seropositivity in juvenile wild ungulates was 1.3%, whereas it was 7.2% in adults. Logistic regression models investigated risk factors for seropositivity. The odds of being seropositive was 3.6 times higher in adults than in juveniles, and the risk was 4.2 times higher in red deer than in wild boar. Both wild ungulate species were exposed to HEV. The higher seroprevalence in red deer suggests that this species may make a major contribution to the ecology of HEV in Central Portugal. Further research is needed to understand how wildlife affects the epidemiology of HEV infections in Portugal.: This research was funded by projects UIDP/00772/2020 and LA/P/0059/2020, funded by the Portuguese Foundation for Science and Technology (FCT). Sérgio Santos-Silva would like to thank Fundação para a Ciência e a Tecnologia (FCT) for the financial support of his Ph.D. work under the scholarship 2021.09461.BD contract through the Maria de Sousa-2021 program.MDPIRepositório Científico do Instituto Politécnico de Castelo BrancoPires, HumbertoCardoso, LuísLopes, Ana PatríciaFontes, Maria da ConceiçãoSilva, Sérgio SantosMatos, ManuelaPintado, C.S.Figueira, LuisMatos, A.C.Mesquita, João RodrigoCoelho, Ana Cláudia2023-12-19T15:46:45Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.11/8743engPIRES, H. [et al.] 82023) - Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal. Microorganisms. 11:10, E2576. DOI: https://doi.org/10.3390/microorganisms1110257610.3390/microorganisms11102576info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-10T01:48:54Zoai:repositorio.ipcb.pt:10400.11/8743Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:55:42.909099Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
title |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
spellingShingle |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal Pires, Humberto ELISA Hepatitis E virus Portugal Red deer Risk factors Wild boar |
title_short |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
title_full |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
title_fullStr |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
title_full_unstemmed |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
title_sort |
Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal |
author |
Pires, Humberto |
author_facet |
Pires, Humberto Cardoso, Luís Lopes, Ana Patrícia Fontes, Maria da Conceição Silva, Sérgio Santos Matos, Manuela Pintado, C.S. Figueira, Luis Matos, A.C. Mesquita, João Rodrigo Coelho, Ana Cláudia |
author_role |
author |
author2 |
Cardoso, Luís Lopes, Ana Patrícia Fontes, Maria da Conceição Silva, Sérgio Santos Matos, Manuela Pintado, C.S. Figueira, Luis Matos, A.C. Mesquita, João Rodrigo Coelho, Ana Cláudia |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Castelo Branco |
dc.contributor.author.fl_str_mv |
Pires, Humberto Cardoso, Luís Lopes, Ana Patrícia Fontes, Maria da Conceição Silva, Sérgio Santos Matos, Manuela Pintado, C.S. Figueira, Luis Matos, A.C. Mesquita, João Rodrigo Coelho, Ana Cláudia |
dc.subject.por.fl_str_mv |
ELISA Hepatitis E virus Portugal Red deer Risk factors Wild boar |
topic |
ELISA Hepatitis E virus Portugal Red deer Risk factors Wild boar |
description |
Hepatitis E virus (HEV) is a zoonotic foodborne virus with an annual infection prevalence of 20 million human cases, which seriously affects public health and economic development in both developed and developing countries. To better understand the epidemiology of HEV in Central Portugal, a cross-sectional study was conducted from 2016 to 2023 with sera samples from wild ungulates. The seroprevalence and risk factors for HEV seropositivity were evaluated in the present study. Specifically, antibodies against HEV were determined by a commercial enzyme-linked immunesorbent assay (ELISA). Our results show that in the 650 sera samples collected from 298 wild red deer and 352 wild boars in Portugal, 9.1% red deer and 1.7% wild boar were positive for antibodies to HEV. Regarding age, the seropositivity in juvenile wild ungulates was 1.3%, whereas it was 7.2% in adults. Logistic regression models investigated risk factors for seropositivity. The odds of being seropositive was 3.6 times higher in adults than in juveniles, and the risk was 4.2 times higher in red deer than in wild boar. Both wild ungulate species were exposed to HEV. The higher seroprevalence in red deer suggests that this species may make a major contribution to the ecology of HEV in Central Portugal. Further research is needed to understand how wildlife affects the epidemiology of HEV infections in Portugal. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-19T15:46:45Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.11/8743 |
url |
http://hdl.handle.net/10400.11/8743 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PIRES, H. [et al.] 82023) - Prevalence and risk factors for hepatitis E virus in wild boar and red deer in Portugal. Microorganisms. 11:10, E2576. DOI: https://doi.org/10.3390/microorganisms11102576 10.3390/microorganisms11102576 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136443418804224 |