Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury

Detalhes bibliográficos
Autor(a) principal: Fidalgo, Pedro
Data de Publicação: 2024
Outros Autores: Póvoa, Pedro, Germano, Nuno, Karvellas, Constantine J., Cardoso, Filipe S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163820
Resumo: Publisher Copyright: © 2024 American Medical Association. All rights reserved.
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spelling Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver InjuryA Cohort StudyChronic kidney diseaseLiver failureRenal insufficiencyGastroenterologyPublisher Copyright: © 2024 American Medical Association. All rights reserved.Introduction: Acute liver failure (ALF) is a rare disease with high mortality. Acute kidney injury (AKI) following ALF is frequent. We assessed AKI impact on long-term kidney function among ALF survivors. Methods: Observational cohort study including consecutive adult (age ≥16 years) patients with ALF or acute liver injury (ALI) admitted to a Portuguese tertiary center intensive care unit (ICU) between October 2013 and February 2020. KDIGO criteria were used to define AKI and chronic kidney disease (CKD). Primary outcome was the estimated glomerular filtration rate (eGFR), defined by the Chronic Kidney Disease Epidemiology Collaboration formula, at least 1 year after index ICU admission. Results: Among 104 patients with ALF (n = 74) or ALI (n = 30), mean (SD) age was 43.7 (18.0) years, and 44 were male. Among all patients (n = 104), following adjustment for age and SOFA score, AKI during the first 7 ICU days (n AKI = 57 and n renal replacement therapy [RRT] = 32) was independently associated with all-cause mortality (adjusted HR [95% CI] 11.61 [1.49-90.34]; p = 0.019). Among hospital survivors with long-term kidney function available (n = 56), median (interquartile range) >1 year eGFR was 95.3 (75.0-107.7) mL/min/1.73 m2 (mean [SD] follow-up of 3.1 [1.6] years). Among these hospital survivors, following adjustment for baseline eGFR, AKI during the first 7 ICU days (n AKI = 19 and n RRT = 10) was not associated with >1 year eGFR (p = 0.15). At least 1 year after index ICU admission, 5 patients developed CKD, none RRT-dependent. Conclusions: Among ALF or ALI survivors, AKI was not associated with significant long-term loss of kidney function.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNFidalgo, PedroPóvoa, PedroGermano, NunoKarvellas, Constantine J.Cardoso, Filipe S.2024-02-20T00:07:07Z2024-022024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163820eng2341-4545PURE: 83669928https://doi.org/10.1159/000536216info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:49:07Zoai:run.unl.pt:10362/163820Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:52.972970Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
A Cohort Study
title Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
spellingShingle Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
Fidalgo, Pedro
Chronic kidney disease
Liver failure
Renal insufficiency
Gastroenterology
title_short Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
title_full Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
title_fullStr Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
title_full_unstemmed Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
title_sort Long-Term Follow-Up of Kidney Function after Acute Liver Failure or Acute Liver Injury
author Fidalgo, Pedro
author_facet Fidalgo, Pedro
Póvoa, Pedro
Germano, Nuno
Karvellas, Constantine J.
Cardoso, Filipe S.
author_role author
author2 Póvoa, Pedro
Germano, Nuno
Karvellas, Constantine J.
Cardoso, Filipe S.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Fidalgo, Pedro
Póvoa, Pedro
Germano, Nuno
Karvellas, Constantine J.
Cardoso, Filipe S.
dc.subject.por.fl_str_mv Chronic kidney disease
Liver failure
Renal insufficiency
Gastroenterology
topic Chronic kidney disease
Liver failure
Renal insufficiency
Gastroenterology
description Publisher Copyright: © 2024 American Medical Association. All rights reserved.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-20T00:07:07Z
2024-02
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163820
url http://hdl.handle.net/10362/163820
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2341-4545
PURE: 83669928
https://doi.org/10.1159/000536216
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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