The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma
| Autor(a) principal: | |
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| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/23858 |
Resumo: | We are grateful to Paulo Vieira, Cecília Leão, Manuel T. Silva, Nuno Sousa, Jorge Correia- Pinto, Joana Palha, Margarida Correia-Neves, Margarida Lima and Matthew Berry for all their input throughout these studies and critical reading of the manuscript. We are grateful to the patients who joint this study as well as to all members of the Life and Health Sciences Research Institute and School of Health Sciences, University of Minho, who contributed in any way to the development of this work |
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The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphomatoll-like receptorsnon-Hodgkin lymphomasingle nucleotide polymorphismTLR9Science & TechnologyWe are grateful to Paulo Vieira, Cecília Leão, Manuel T. Silva, Nuno Sousa, Jorge Correia- Pinto, Joana Palha, Margarida Correia-Neves, Margarida Lima and Matthew Berry for all their input throughout these studies and critical reading of the manuscript. We are grateful to the patients who joint this study as well as to all members of the Life and Health Sciences Research Institute and School of Health Sciences, University of Minho, who contributed in any way to the development of this workNon-Hodgkin lymphoma (NHL) has been associated with immunological defects, chronic inflammatory and autoimmune conditions. Given the link between immune dysfunction and NHL, genetic variants in toll-like receptors (TLRs) have been regarded as potential predictive factors of susceptibility to NHL. Adequate anti-tumoral responses are known to depend on TLR9 function, such that the use of its synthetic ligand is being targeted as a therapeutic strategy. We investigated the association between the functional rs5743836 polymorphism in the TLR9 promoter and risk for B-cell NHL and its major subtypes in three independent case-control association studies from Portugal (1160 controls, 797 patients), Italy (468 controls, 494 patients) and the US (972 controls, 868 patients). We found that the rs5743836 polymorphism was significantly overtransmitted in both Portuguese (odds ratio (OR), 1.85; P=7.3E-9) and Italian (OR, 1.84; P=6.0E-5) and not in the US cohort of NHL patients. Moreover, the increased transcriptional activity of TLR9 in mononuclear cells from patients harboring rs5743836 further supports a functional effect of this polymorphism on NHL susceptibility in a population-dependent manner.AC, NSO, MTC, and AJA were financially supported by a fellowship from Fundação para a Ciência e Tecnologia, Portugal. MS is a Ciência 2007 fellow. This study was supported by Fundação para a Ciência e Tecnologia, Portugal (PIC/IC/83313/2007) and by Fundação Calouste Gulbenkian, Serviço de Saúde e Desenvolvimento Humano, Portugal (Grant Number:Proc/60666-MM/734). CFS, PB and LC were supported by National Institutes of Health (NIH) grants CA122663 and CA104682, and PB also by NIH grants CA45614 and CA89745.Nature Publishing GroupUniversidade do MinhoCarvalho, AgostinhoCunha, CristinaAlmeida, A. J.Osório, Nuno S.Saraiva, MargaridaCoelho, Maria TeixeiraPedreiro, SusanaTorrado, EgídioDomingues, NelsonMarques, AntónioLacerda, João F.Silva, Maria Gomes daGomes, MaríliaPinto, Ana C.Torres, FátimaRendeiro, PaulaTavares, PurificaçãoIanni, Mauro deMedeiros, RuiHeutink, PeterBracci, Paige M.Conde, LuciaLudovico, PaulaPedrosa, JorgeMaciel, P.Pitzurra, LuciaAversa, FrancoMarques, HerlanderPaiva, ArturSkibola, Christine F.Romani, LuiginaCastro, António G.Rodrigues, Fernando José dos Santos2012-022012-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/23858eng1466-487910.1038/gene.2011.5921866115http://www.nature.com/gene/journal/v13/n2/full/gene201159a.htmlinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:03:28Zoai:repositorium.sdum.uminho.pt:1822/23858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:53:36.363214Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| title |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| spellingShingle |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma Carvalho, Agostinho toll-like receptors non-Hodgkin lymphoma single nucleotide polymorphism TLR9 Science & Technology |
| title_short |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| title_full |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| title_fullStr |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| title_full_unstemmed |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| title_sort |
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma |
| author |
Carvalho, Agostinho |
| author_facet |
Carvalho, Agostinho Cunha, Cristina Almeida, A. J. Osório, Nuno S. Saraiva, Margarida Coelho, Maria Teixeira Pedreiro, Susana Torrado, Egídio Domingues, Nelson Marques, António Lacerda, João F. Silva, Maria Gomes da Gomes, Marília Pinto, Ana C. Torres, Fátima Rendeiro, Paula Tavares, Purificação Ianni, Mauro de Medeiros, Rui Heutink, Peter Bracci, Paige M. Conde, Lucia Ludovico, Paula Pedrosa, Jorge Maciel, P. Pitzurra, Lucia Aversa, Franco Marques, Herlander Paiva, Artur Skibola, Christine F. Romani, Luigina Castro, António G. Rodrigues, Fernando José dos Santos |
| author_role |
author |
| author2 |
Cunha, Cristina Almeida, A. J. Osório, Nuno S. Saraiva, Margarida Coelho, Maria Teixeira Pedreiro, Susana Torrado, Egídio Domingues, Nelson Marques, António Lacerda, João F. Silva, Maria Gomes da Gomes, Marília Pinto, Ana C. Torres, Fátima Rendeiro, Paula Tavares, Purificação Ianni, Mauro de Medeiros, Rui Heutink, Peter Bracci, Paige M. Conde, Lucia Ludovico, Paula Pedrosa, Jorge Maciel, P. Pitzurra, Lucia Aversa, Franco Marques, Herlander Paiva, Artur Skibola, Christine F. Romani, Luigina Castro, António G. Rodrigues, Fernando José dos Santos |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Carvalho, Agostinho Cunha, Cristina Almeida, A. J. Osório, Nuno S. Saraiva, Margarida Coelho, Maria Teixeira Pedreiro, Susana Torrado, Egídio Domingues, Nelson Marques, António Lacerda, João F. Silva, Maria Gomes da Gomes, Marília Pinto, Ana C. Torres, Fátima Rendeiro, Paula Tavares, Purificação Ianni, Mauro de Medeiros, Rui Heutink, Peter Bracci, Paige M. Conde, Lucia Ludovico, Paula Pedrosa, Jorge Maciel, P. Pitzurra, Lucia Aversa, Franco Marques, Herlander Paiva, Artur Skibola, Christine F. Romani, Luigina Castro, António G. Rodrigues, Fernando José dos Santos |
| dc.subject.por.fl_str_mv |
toll-like receptors non-Hodgkin lymphoma single nucleotide polymorphism TLR9 Science & Technology |
| topic |
toll-like receptors non-Hodgkin lymphoma single nucleotide polymorphism TLR9 Science & Technology |
| description |
We are grateful to Paulo Vieira, Cecília Leão, Manuel T. Silva, Nuno Sousa, Jorge Correia- Pinto, Joana Palha, Margarida Correia-Neves, Margarida Lima and Matthew Berry for all their input throughout these studies and critical reading of the manuscript. We are grateful to the patients who joint this study as well as to all members of the Life and Health Sciences Research Institute and School of Health Sciences, University of Minho, who contributed in any way to the development of this work |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-02 2012-02-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1822/23858 |
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http://hdl.handle.net/1822/23858 |
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eng |
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eng |
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1466-4879 10.1038/gene.2011.59 21866115 http://www.nature.com/gene/journal/v13/n2/full/gene201159a.html |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Nature Publishing Group |
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Nature Publishing Group |
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