The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2824 |
Resumo: | urpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia. |
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The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopescircumpapillary microperimetryglaucomahigh myopiaoptic disc dysgenesispapillary optical coherence tomography giographyperipapillary retinal nerve fiber layer thicknessurpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.Dove Medical PressRepositório Científico do Centro Hospitalar Universitário de Santo AntónioBaptista, Pedro ManuelVieira, RitaFerreira, AndréFigueiredo, AnaSampaio, IsabelReis, RitaMenéres, Maria João2023-10-19T11:30:44Z2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2824engBaptista PM, Vieira R, Ferreira A, et al. The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes. Clin Ophthalmol. 2021;15:1061-1071. doi:10.2147/OPTH.S3017811177-546710.2147/OPTH.S301781info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:03:41Zoai:repositorio.chporto.pt:10400.16/2824Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:59.945237Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
title |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
spellingShingle |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes Baptista, Pedro Manuel circumpapillary microperimetry glaucoma high myopia optic disc dysgenesis papillary optical coherence tomography giography peripapillary retinal nerve fiber layer thickness |
title_short |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
title_full |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
title_fullStr |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
title_full_unstemmed |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
title_sort |
The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes |
author |
Baptista, Pedro Manuel |
author_facet |
Baptista, Pedro Manuel Vieira, Rita Ferreira, André Figueiredo, Ana Sampaio, Isabel Reis, Rita Menéres, Maria João |
author_role |
author |
author2 |
Vieira, Rita Ferreira, André Figueiredo, Ana Sampaio, Isabel Reis, Rita Menéres, Maria João |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Baptista, Pedro Manuel Vieira, Rita Ferreira, André Figueiredo, Ana Sampaio, Isabel Reis, Rita Menéres, Maria João |
dc.subject.por.fl_str_mv |
circumpapillary microperimetry glaucoma high myopia optic disc dysgenesis papillary optical coherence tomography giography peripapillary retinal nerve fiber layer thickness |
topic |
circumpapillary microperimetry glaucoma high myopia optic disc dysgenesis papillary optical coherence tomography giography peripapillary retinal nerve fiber layer thickness |
description |
urpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03 2021-03-01T00:00:00Z 2023-10-19T11:30:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2824 |
url |
http://hdl.handle.net/10400.16/2824 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Baptista PM, Vieira R, Ferreira A, et al. The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes. Clin Ophthalmol. 2021;15:1061-1071. doi:10.2147/OPTH.S301781 1177-5467 10.2147/OPTH.S301781 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Dove Medical Press |
publisher.none.fl_str_mv |
Dove Medical Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133650268192768 |