The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes

Detalhes bibliográficos
Autor(a) principal: Baptista, Pedro Manuel
Data de Publicação: 2021
Outros Autores: Vieira, Rita, Ferreira, André, Figueiredo, Ana, Sampaio, Isabel, Reis, Rita, Menéres, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2824
Resumo: urpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.
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spelling The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopescircumpapillary microperimetryglaucomahigh myopiaoptic disc dysgenesispapillary optical coherence tomography giographyperipapillary retinal nerve fiber layer thicknessurpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.Dove Medical PressRepositório Científico do Centro Hospitalar Universitário de Santo AntónioBaptista, Pedro ManuelVieira, RitaFerreira, AndréFigueiredo, AnaSampaio, IsabelReis, RitaMenéres, Maria João2023-10-19T11:30:44Z2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2824engBaptista PM, Vieira R, Ferreira A, et al. The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes. Clin Ophthalmol. 2021;15:1061-1071. doi:10.2147/OPTH.S3017811177-546710.2147/OPTH.S301781info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:03:41Zoai:repositorio.chporto.pt:10400.16/2824Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:59.945237Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
spellingShingle The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
Baptista, Pedro Manuel
circumpapillary microperimetry
glaucoma
high myopia
optic disc dysgenesis
papillary optical coherence tomography giography
peripapillary retinal nerve fiber layer thickness
title_short The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_full The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_fullStr The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_full_unstemmed The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_sort The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
author Baptista, Pedro Manuel
author_facet Baptista, Pedro Manuel
Vieira, Rita
Ferreira, André
Figueiredo, Ana
Sampaio, Isabel
Reis, Rita
Menéres, Maria João
author_role author
author2 Vieira, Rita
Ferreira, André
Figueiredo, Ana
Sampaio, Isabel
Reis, Rita
Menéres, Maria João
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Baptista, Pedro Manuel
Vieira, Rita
Ferreira, André
Figueiredo, Ana
Sampaio, Isabel
Reis, Rita
Menéres, Maria João
dc.subject.por.fl_str_mv circumpapillary microperimetry
glaucoma
high myopia
optic disc dysgenesis
papillary optical coherence tomography giography
peripapillary retinal nerve fiber layer thickness
topic circumpapillary microperimetry
glaucoma
high myopia
optic disc dysgenesis
papillary optical coherence tomography giography
peripapillary retinal nerve fiber layer thickness
description urpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients. Patients and methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®). Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p<0.001). The GG showed lower values in all ppRNFLTs (p<0.05), lower values in all SVDs (p<0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p<0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively. Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
2021-03-01T00:00:00Z
2023-10-19T11:30:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2824
url http://hdl.handle.net/10400.16/2824
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Baptista PM, Vieira R, Ferreira A, et al. The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes. Clin Ophthalmol. 2021;15:1061-1071. doi:10.2147/OPTH.S301781
1177-5467
10.2147/OPTH.S301781
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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