Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/14279 https://doi.org/10.1118/1.4876379 |
Resumo: | PURPOSE: The objectives are: (i) assess the development of the impedance of some arteries during the first decades of life; (ii) determine the influence of pulse rate in arterial impedance; (iii) compare the structure of some arterial segments with optimized structures with respect to blood flow; and (iv) explain the elongation of the ascending aorta throughout life in healthy subjects. METHODS: A model of the arterial network previously developed by the authors, together with data of lengths, diameters, and distensibilities of arterial segments reported in the literature were used. The impedances of the aorta and carotid artery were calculated based on that model. Similarly, the impedances of various arteries corresponding to heart rates of 65 bpm and 120 bpm were calculated. Values observed in arterial segments were compared with the respective optimal values from the viewpoint of hemodynamic performance. This allowed drawing conclusions on the arterial segments that might be critical with regard to hemodynamics. RESULTS: It was found that in healthy people impedances of the aorta and the carotid artery decrease markedly with age especially during body growth. It was also found that impedances of the main arteries do not significantly change with heart rate, even if sharp changes in arterial distensibility are observed. With respect to optimal flow performance, it was found that scaling between diameters of branching arteries is generally close to optimality, while the corresponding length scaling is far from optimality. It was also found that the ascending aorta and aortic arch are among those arterial segments whose lengths are much smaller than the optimum values. An explanation is offered for the age associated elongation of the aorta in healthy people. CONCLUSIONS: In healthy subjects, the human arterial system continues to optimize its performance at least until the age of 60. |
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Structure and adaptation of arteries to pulsatile flow - The case of the ascending aortaPulsatile flowArterial structurePURPOSE: The objectives are: (i) assess the development of the impedance of some arteries during the first decades of life; (ii) determine the influence of pulse rate in arterial impedance; (iii) compare the structure of some arterial segments with optimized structures with respect to blood flow; and (iv) explain the elongation of the ascending aorta throughout life in healthy subjects. METHODS: A model of the arterial network previously developed by the authors, together with data of lengths, diameters, and distensibilities of arterial segments reported in the literature were used. The impedances of the aorta and carotid artery were calculated based on that model. Similarly, the impedances of various arteries corresponding to heart rates of 65 bpm and 120 bpm were calculated. Values observed in arterial segments were compared with the respective optimal values from the viewpoint of hemodynamic performance. This allowed drawing conclusions on the arterial segments that might be critical with regard to hemodynamics. RESULTS: It was found that in healthy people impedances of the aorta and the carotid artery decrease markedly with age especially during body growth. It was also found that impedances of the main arteries do not significantly change with heart rate, even if sharp changes in arterial distensibility are observed. With respect to optimal flow performance, it was found that scaling between diameters of branching arteries is generally close to optimality, while the corresponding length scaling is far from optimality. It was also found that the ascending aorta and aortic arch are among those arterial segments whose lengths are much smaller than the optimum values. An explanation is offered for the age associated elongation of the aorta in healthy people. CONCLUSIONS: In healthy subjects, the human arterial system continues to optimize its performance at least until the age of 60.AIP2015-05-04T16:12:44Z2015-05-042014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/14279http://hdl.handle.net/10174/14279https://doi.org/10.1118/1.4876379engC. Silva, A. H. Reis, “Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta”, Medical Physics 41, 6, 063701 (2014).carlasilva@ipt.pt354Silva, Carlainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:00:30Zoai:dspace.uevora.pt:10174/14279Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:07:35.254661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
title |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
spellingShingle |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta Silva, Carla Pulsatile flow Arterial structure |
title_short |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
title_full |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
title_fullStr |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
title_full_unstemmed |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
title_sort |
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta |
author |
Silva, Carla |
author_facet |
Silva, Carla |
author_role |
author |
dc.contributor.author.fl_str_mv |
Silva, Carla |
dc.subject.por.fl_str_mv |
Pulsatile flow Arterial structure |
topic |
Pulsatile flow Arterial structure |
description |
PURPOSE: The objectives are: (i) assess the development of the impedance of some arteries during the first decades of life; (ii) determine the influence of pulse rate in arterial impedance; (iii) compare the structure of some arterial segments with optimized structures with respect to blood flow; and (iv) explain the elongation of the ascending aorta throughout life in healthy subjects. METHODS: A model of the arterial network previously developed by the authors, together with data of lengths, diameters, and distensibilities of arterial segments reported in the literature were used. The impedances of the aorta and carotid artery were calculated based on that model. Similarly, the impedances of various arteries corresponding to heart rates of 65 bpm and 120 bpm were calculated. Values observed in arterial segments were compared with the respective optimal values from the viewpoint of hemodynamic performance. This allowed drawing conclusions on the arterial segments that might be critical with regard to hemodynamics. RESULTS: It was found that in healthy people impedances of the aorta and the carotid artery decrease markedly with age especially during body growth. It was also found that impedances of the main arteries do not significantly change with heart rate, even if sharp changes in arterial distensibility are observed. With respect to optimal flow performance, it was found that scaling between diameters of branching arteries is generally close to optimality, while the corresponding length scaling is far from optimality. It was also found that the ascending aorta and aortic arch are among those arterial segments whose lengths are much smaller than the optimum values. An explanation is offered for the age associated elongation of the aorta in healthy people. CONCLUSIONS: In healthy subjects, the human arterial system continues to optimize its performance at least until the age of 60. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01T00:00:00Z 2015-05-04T16:12:44Z 2015-05-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/14279 http://hdl.handle.net/10174/14279 https://doi.org/10.1118/1.4876379 |
url |
http://hdl.handle.net/10174/14279 https://doi.org/10.1118/1.4876379 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
C. Silva, A. H. Reis, “Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta”, Medical Physics 41, 6, 063701 (2014). carlasilva@ipt.pt 354 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
AIP |
publisher.none.fl_str_mv |
AIP |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136560322445312 |