A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/123684 |
Resumo: | Several problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where the active compound is transported to the target site, minimizing undesirable side effects. In situ-forming hydrogels that can be injected as viscous liquids and jellify under physiological conditions and biocompatible clay nanoparticles have been used in DDS development. In this work, polymer–clay composites based on Pluronics (F127 and F68) and nanoclays were developed, aiming at a biocompatible and injectable system for long-term controlled delivery of methylene blue (MB) as a model drug. MB release from the systems produced was carried out at 37◦C in a pH 7.4 medium. The Pluronic formulation selected (F127/F68 18/2 wt.%) displayed a sol/gel transition at approx. 30◦C, needing a 2.5 N force to be injected at 25◦C. The addition of 2 wt.% of Na116 clay decreased the sol/gel transition to 28◦C and significantly enhanced its viscoelastic modulus. The most suitable DDS for long-term application was the Na116-MB hybrid from which, after 15 days, only 3% of the encapsulated MB was released. The system developed in this work proved to be injectable, with a long-term drug delivery profile up to 45 days. |
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A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclayBiomaterialsInjectable hydrogelsLong-term drug deliveryNanoclayChemical Engineering(all)Materials Science(all)Several problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where the active compound is transported to the target site, minimizing undesirable side effects. In situ-forming hydrogels that can be injected as viscous liquids and jellify under physiological conditions and biocompatible clay nanoparticles have been used in DDS development. In this work, polymer–clay composites based on Pluronics (F127 and F68) and nanoclays were developed, aiming at a biocompatible and injectable system for long-term controlled delivery of methylene blue (MB) as a model drug. MB release from the systems produced was carried out at 37◦C in a pH 7.4 medium. The Pluronic formulation selected (F127/F68 18/2 wt.%) displayed a sol/gel transition at approx. 30◦C, needing a 2.5 N force to be injected at 25◦C. The addition of 2 wt.% of Na116 clay decreased the sol/gel transition to 28◦C and significantly enhanced its viscoelastic modulus. The most suitable DDS for long-term application was the Na116-MB hybrid from which, after 15 days, only 3% of the encapsulated MB was released. The system developed in this work proved to be injectable, with a long-term drug delivery profile up to 45 days.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DF – Departamento de FísicaRUNTipa, CezarCidade, Maria T.Vieira, TâniaSilva, Jorge CarvalhoSoares, Paula I. P.Borges, João Paulo2021-09-03T00:11:52Z2021-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22application/pdfhttp://hdl.handle.net/10362/123684eng2079-4991PURE: 27600205https://doi.org/10.3390/nano11010025info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:05:01Zoai:run.unl.pt:10362/123684Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:08.653106Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
title |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
spellingShingle |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay Tipa, Cezar Biomaterials Injectable hydrogels Long-term drug delivery Nanoclay Chemical Engineering(all) Materials Science(all) |
title_short |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
title_full |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
title_fullStr |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
title_full_unstemmed |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
title_sort |
A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay |
author |
Tipa, Cezar |
author_facet |
Tipa, Cezar Cidade, Maria T. Vieira, Tânia Silva, Jorge Carvalho Soares, Paula I. P. Borges, João Paulo |
author_role |
author |
author2 |
Cidade, Maria T. Vieira, Tânia Silva, Jorge Carvalho Soares, Paula I. P. Borges, João Paulo |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
DCM - Departamento de Ciência dos Materiais CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DF – Departamento de Física RUN |
dc.contributor.author.fl_str_mv |
Tipa, Cezar Cidade, Maria T. Vieira, Tânia Silva, Jorge Carvalho Soares, Paula I. P. Borges, João Paulo |
dc.subject.por.fl_str_mv |
Biomaterials Injectable hydrogels Long-term drug delivery Nanoclay Chemical Engineering(all) Materials Science(all) |
topic |
Biomaterials Injectable hydrogels Long-term drug delivery Nanoclay Chemical Engineering(all) Materials Science(all) |
description |
Several problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where the active compound is transported to the target site, minimizing undesirable side effects. In situ-forming hydrogels that can be injected as viscous liquids and jellify under physiological conditions and biocompatible clay nanoparticles have been used in DDS development. In this work, polymer–clay composites based on Pluronics (F127 and F68) and nanoclays were developed, aiming at a biocompatible and injectable system for long-term controlled delivery of methylene blue (MB) as a model drug. MB release from the systems produced was carried out at 37◦C in a pH 7.4 medium. The Pluronic formulation selected (F127/F68 18/2 wt.%) displayed a sol/gel transition at approx. 30◦C, needing a 2.5 N force to be injected at 25◦C. The addition of 2 wt.% of Na116 clay decreased the sol/gel transition to 28◦C and significantly enhanced its viscoelastic modulus. The most suitable DDS for long-term application was the Na116-MB hybrid from which, after 15 days, only 3% of the encapsulated MB was released. The system developed in this work proved to be injectable, with a long-term drug delivery profile up to 45 days. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-03T00:11:52Z 2021-01 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/123684 |
url |
http://hdl.handle.net/10362/123684 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2079-4991 PURE: 27600205 https://doi.org/10.3390/nano11010025 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
22 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138057376497664 |