The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Detalhes bibliográficos
Autor(a) principal: Paragomi, P
Data de Publicação: 2022
Outros Autores: Dabo, B, Pelucchi, C, Bonzi, R, Bako, AT, Sanusi, NM, Nguyen, QH, Zhang, Z-F, Palli, D, Ferraroni, M, Vu, KT, Yu, G-P, Turati, F, Zaridze, D, Maximovitch, D, Hu, J, Mu, L, Boccia, S, Pastorino, R, Tsugane, S, Hidaka, A, Kurtz, RC, Lagiou, A, Lagiou, P, Camargo, MC, Curado, MP, Lunet, N, Vioque, J, Boffetta, P, Negri, E, La Vecchia, C, Luu, HN
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/151476
Resumo: Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk. © 2022 by the authors.
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spelling The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortiumduodenal ulcers (DUs); gastric cancer; Gastric ulcers (Gus); risk factorsBackground. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk. © 2022 by the authors.MDPI20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/151476eng2072-669410.3390/cancers14194905Paragomi, PDabo, BPelucchi, CBonzi, RBako, ATSanusi, NMNguyen, QHZhang, Z-FPalli, DFerraroni, MVu, KTYu, G-PTurati, FZaridze, DMaximovitch, DHu, JMu, LBoccia, SPastorino, RTsugane, SHidaka, AKurtz, RCLagiou, ALagiou, PCamargo, MCCurado, MPLunet, NVioque, JBoffetta, PNegri, ELa Vecchia, CLuu, HNinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:11:02Zoai:repositorio-aberto.up.pt:10216/151476Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:56:35.235202Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
title The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
spellingShingle The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
Paragomi, P
duodenal ulcers (DUs); gastric cancer; Gastric ulcers (Gus); risk factors
title_short The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
title_full The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
title_fullStr The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
title_full_unstemmed The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
title_sort The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium
author Paragomi, P
author_facet Paragomi, P
Dabo, B
Pelucchi, C
Bonzi, R
Bako, AT
Sanusi, NM
Nguyen, QH
Zhang, Z-F
Palli, D
Ferraroni, M
Vu, KT
Yu, G-P
Turati, F
Zaridze, D
Maximovitch, D
Hu, J
Mu, L
Boccia, S
Pastorino, R
Tsugane, S
Hidaka, A
Kurtz, RC
Lagiou, A
Lagiou, P
Camargo, MC
Curado, MP
Lunet, N
Vioque, J
Boffetta, P
Negri, E
La Vecchia, C
Luu, HN
author_role author
author2 Dabo, B
Pelucchi, C
Bonzi, R
Bako, AT
Sanusi, NM
Nguyen, QH
Zhang, Z-F
Palli, D
Ferraroni, M
Vu, KT
Yu, G-P
Turati, F
Zaridze, D
Maximovitch, D
Hu, J
Mu, L
Boccia, S
Pastorino, R
Tsugane, S
Hidaka, A
Kurtz, RC
Lagiou, A
Lagiou, P
Camargo, MC
Curado, MP
Lunet, N
Vioque, J
Boffetta, P
Negri, E
La Vecchia, C
Luu, HN
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paragomi, P
Dabo, B
Pelucchi, C
Bonzi, R
Bako, AT
Sanusi, NM
Nguyen, QH
Zhang, Z-F
Palli, D
Ferraroni, M
Vu, KT
Yu, G-P
Turati, F
Zaridze, D
Maximovitch, D
Hu, J
Mu, L
Boccia, S
Pastorino, R
Tsugane, S
Hidaka, A
Kurtz, RC
Lagiou, A
Lagiou, P
Camargo, MC
Curado, MP
Lunet, N
Vioque, J
Boffetta, P
Negri, E
La Vecchia, C
Luu, HN
dc.subject.por.fl_str_mv duodenal ulcers (DUs); gastric cancer; Gastric ulcers (Gus); risk factors
topic duodenal ulcers (DUs); gastric cancer; Gastric ulcers (Gus); risk factors
description Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk. © 2022 by the authors.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/151476
url https://hdl.handle.net/10216/151476
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
10.3390/cancers14194905
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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