Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult

Detalhes bibliográficos
Autor(a) principal: Luís, Helena
Data de Publicação: 2021
Outros Autores: Barros, Carolina, Gomes, Mariana, Andrade, José Luís, Faria, Nancy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/37857
Resumo: Cytomegalovirus (CMV) is a linear double-stranded DNA virus that may cause severe and potentially fatal infection in immunocompromised hosts. In immunocompetent individuals, the infection is typically mild or asymptomatic. However, in the last years, some cases of severe cytomegalovirus infection in immunocompetent individuals have been described. Clinical Presentation. 'e authors present a male patient aged 42 years, without specific medical history, who presented a 15-day history of fever, headache, night sweats, odynophagia, and bilateral otalgia, without improvement after four days of therapy with amoxicillin/clavulanic acid. Blood count and biochemistry were performed with liver cytolysis pattern. Chest teleradiography showed diffuse interstitial infiltrate. 'oracic CT scan revealed areas in a ground glass with a cross-linking component in the left and right upper lung lobes compatible with an inflammatory/infectious process. Blood serology was positive for CMV IgG and IgM. 'e detection on blood and bronchoalveolar lavage of CMV DNA by polymerase chain reaction (PCR) was also positive. Ganciclovir was started based on the clinical features and the result of CMV serology. After 48 hours, there was a significant clinical improvement, with remission of fever, and he was discharged on the 13th day of hospitalization with oral valganciclovir, completing a 21-day antiviral course at home. Conclusion. With this clinical case, the authors highlight the importance of considering CMV infection in evaluating patients with pneumonia, even in immunocompetent ones, particularly in those with no clinical improvement with antibiotics instituted for bacterial pneumonia, and when other causes have been ruled out
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spelling Cytomegalovirus Pulmonary Involvement in an Immunocompetent AdultCytomegalovirus Pulmonary InvolvementPulmonary DiseaseMadeira IslandPortugalRegião Autónoma da Madeiraimmunocompromized patientCMV infectionpneumoniaCytomegalovirus (CMV) is a linear double-stranded DNA virus that may cause severe and potentially fatal infection in immunocompromised hosts. In immunocompetent individuals, the infection is typically mild or asymptomatic. However, in the last years, some cases of severe cytomegalovirus infection in immunocompetent individuals have been described. Clinical Presentation. 'e authors present a male patient aged 42 years, without specific medical history, who presented a 15-day history of fever, headache, night sweats, odynophagia, and bilateral otalgia, without improvement after four days of therapy with amoxicillin/clavulanic acid. Blood count and biochemistry were performed with liver cytolysis pattern. Chest teleradiography showed diffuse interstitial infiltrate. 'oracic CT scan revealed areas in a ground glass with a cross-linking component in the left and right upper lung lobes compatible with an inflammatory/infectious process. Blood serology was positive for CMV IgG and IgM. 'e detection on blood and bronchoalveolar lavage of CMV DNA by polymerase chain reaction (PCR) was also positive. Ganciclovir was started based on the clinical features and the result of CMV serology. After 48 hours, there was a significant clinical improvement, with remission of fever, and he was discharged on the 13th day of hospitalization with oral valganciclovir, completing a 21-day antiviral course at home. Conclusion. With this clinical case, the authors highlight the importance of considering CMV infection in evaluating patients with pneumonia, even in immunocompetent ones, particularly in those with no clinical improvement with antibiotics instituted for bacterial pneumonia, and when other causes have been ruled outHindawiRepositório ComumLuís, HelenaBarros, CarolinaGomes, MarianaAndrade, José LuísFaria, Nancy2021-10-29T15:56:30Z2021-05-272021-05-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/37857engHindawi Case Reports in Infectious Diseases Volume 2021, Article ID 4226386, 6 pages10.1155/2021/4226386info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-10T02:18:40Zoai:comum.rcaap.pt:10400.26/37857Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:34:35.858829Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
title Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
spellingShingle Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
Luís, Helena
Cytomegalovirus Pulmonary Involvement
Pulmonary Disease
Madeira Island
Portugal
Região Autónoma da Madeira
immunocompromized patient
CMV infection
pneumonia
title_short Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
title_full Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
title_fullStr Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
title_full_unstemmed Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
title_sort Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult
author Luís, Helena
author_facet Luís, Helena
Barros, Carolina
Gomes, Mariana
Andrade, José Luís
Faria, Nancy
author_role author
author2 Barros, Carolina
Gomes, Mariana
Andrade, José Luís
Faria, Nancy
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Luís, Helena
Barros, Carolina
Gomes, Mariana
Andrade, José Luís
Faria, Nancy
dc.subject.por.fl_str_mv Cytomegalovirus Pulmonary Involvement
Pulmonary Disease
Madeira Island
Portugal
Região Autónoma da Madeira
immunocompromized patient
CMV infection
pneumonia
topic Cytomegalovirus Pulmonary Involvement
Pulmonary Disease
Madeira Island
Portugal
Região Autónoma da Madeira
immunocompromized patient
CMV infection
pneumonia
description Cytomegalovirus (CMV) is a linear double-stranded DNA virus that may cause severe and potentially fatal infection in immunocompromised hosts. In immunocompetent individuals, the infection is typically mild or asymptomatic. However, in the last years, some cases of severe cytomegalovirus infection in immunocompetent individuals have been described. Clinical Presentation. 'e authors present a male patient aged 42 years, without specific medical history, who presented a 15-day history of fever, headache, night sweats, odynophagia, and bilateral otalgia, without improvement after four days of therapy with amoxicillin/clavulanic acid. Blood count and biochemistry were performed with liver cytolysis pattern. Chest teleradiography showed diffuse interstitial infiltrate. 'oracic CT scan revealed areas in a ground glass with a cross-linking component in the left and right upper lung lobes compatible with an inflammatory/infectious process. Blood serology was positive for CMV IgG and IgM. 'e detection on blood and bronchoalveolar lavage of CMV DNA by polymerase chain reaction (PCR) was also positive. Ganciclovir was started based on the clinical features and the result of CMV serology. After 48 hours, there was a significant clinical improvement, with remission of fever, and he was discharged on the 13th day of hospitalization with oral valganciclovir, completing a 21-day antiviral course at home. Conclusion. With this clinical case, the authors highlight the importance of considering CMV infection in evaluating patients with pneumonia, even in immunocompetent ones, particularly in those with no clinical improvement with antibiotics instituted for bacterial pneumonia, and when other causes have been ruled out
publishDate 2021
dc.date.none.fl_str_mv 2021-10-29T15:56:30Z
2021-05-27
2021-05-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/37857
url http://hdl.handle.net/10400.26/37857
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hindawi Case Reports in Infectious Diseases Volume 2021, Article ID 4226386, 6 pages
10.1155/2021/4226386
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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