Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks

Detalhes bibliográficos
Autor(a) principal: Cardoso, Manuela
Data de Publicação: 2023
Outros Autores: Virella, Daniel, Papoila, Ana Luísa, Alves, Marta, Macedo, Israel, E Silva, Diana, Pereira-da-Silva, Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151627
Resumo: Funding: This study was partially supported by the Portuguese Neonatal Society through the Grant ‘Nutricia Early Life Nutrition 2019’.
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spelling Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 WeeksA Mixed-Cohort Studyadipositybody compositiongrowth velocityhuman milk fortificationpreterm infantsFood ScienceNutrition and DieteticsFunding: This study was partially supported by the Portuguese Neonatal Society through the Grant ‘Nutricia Early Life Nutrition 2019’.The optimal method for human milk (HM) fortification has not yet been determined. This study assessed whether fortification relying on measured HM macronutrient content (Miris AB analyzer, Upsala, Sweden) composition is superior to fortification based on assumed HM macronutrient content, to optimize the nutrition support, growth, and body composition in infants born at <33 weeks' gestation. In a mixed-cohort study, 57 infants fed fortified HM based on its measured content were compared with 58 infants fed fortified HM based on its assumed content, for a median of 28 and 23 exposure days, respectively. The ESPGHAN 2010 guidelines for preterm enteral nutrition were followed. Growth assessment was based on body weight, length, and head circumference Δ z-scores, and the respective growth velocities until discharge. Body composition was assessed using air displacement plethysmography. Fortification based on measured HM content provided significantly higher energy, fat, and carbohydrate intakes, although with a lower protein intake in infants weighing ≥ 1 kg and lower protein-to-energy ratio in infants weighing < 1 kg. Infants fed fortified HM based on its measured content were discharged with significantly better weight gain, length, and head growth. These infants had significantly lower adiposity and greater lean mass near term-equivalent age, despite receiving higher in-hospital energy and fat intakes, with a mean fat intake higher than the maximum recommended and a median protein-to-energy ratio intake (in infants weighing < 1 kg) lower than the minimum recommended.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNCardoso, ManuelaVirella, DanielPapoila, Ana LuísaAlves, MartaMacedo, IsraelE Silva, DianaPereira-da-Silva, Luís2023-04-05T22:18:15Z2023-03-222023-03-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/151627eng1422-8599PURE: 57708558https://doi.org/10.3390/nu15061533info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:10:50Zoai:run.unl.pt:10362/151627Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:10:50Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
A Mixed-Cohort Study
title Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
spellingShingle Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
Cardoso, Manuela
adiposity
body composition
growth velocity
human milk fortification
preterm infants
Food Science
Nutrition and Dietetics
title_short Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
title_full Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
title_fullStr Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
title_full_unstemmed Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
title_sort Individualized Fortification Based on Measured Macronutrient Content of Human Milk Improves Growth and Body Composition in Infants Born Less than 33 Weeks
author Cardoso, Manuela
author_facet Cardoso, Manuela
Virella, Daniel
Papoila, Ana Luísa
Alves, Marta
Macedo, Israel
E Silva, Diana
Pereira-da-Silva, Luís
author_role author
author2 Virella, Daniel
Papoila, Ana Luísa
Alves, Marta
Macedo, Israel
E Silva, Diana
Pereira-da-Silva, Luís
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Cardoso, Manuela
Virella, Daniel
Papoila, Ana Luísa
Alves, Marta
Macedo, Israel
E Silva, Diana
Pereira-da-Silva, Luís
dc.subject.por.fl_str_mv adiposity
body composition
growth velocity
human milk fortification
preterm infants
Food Science
Nutrition and Dietetics
topic adiposity
body composition
growth velocity
human milk fortification
preterm infants
Food Science
Nutrition and Dietetics
description Funding: This study was partially supported by the Portuguese Neonatal Society through the Grant ‘Nutricia Early Life Nutrition 2019’.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-05T22:18:15Z
2023-03-22
2023-03-22T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151627
url http://hdl.handle.net/10362/151627
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-8599
PURE: 57708558
https://doi.org/10.3390/nu15061533
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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