Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/119319 |
Resumo: | Funding: This study was supported in part by a grant from the French government through the «Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). The funders of the study had no role in the study design, data collection, analysis, or interpreta tion, writing of the report, or decision to submit for publication. |
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Relationship between ventilator-associated pneumonia and mortality in COVID-19 patientsa planned ancillary analysis of the coVAPid cohortCOVID-19MortalityVentilator-associated pneumoniaCritical Care and Intensive Care MedicineFunding: This study was supported in part by a grant from the French government through the «Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). The funders of the study had no role in the study design, data collection, analysis, or interpreta tion, writing of the report, or decision to submit for publication.BACKGROUND: Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients. METHODS: Planned ancillary analysis of a multicenter retrospective European cohort. VAP was diagnosed using clinical, radiological and quantitative microbiological criteria. Univariable and multivariable marginal Cox's regression models, with cause-specific hazard for duration of mechanical ventilation and ICU stay, were used to compare outcomes between study groups. Extubation, and ICU discharge alive were considered as events of interest, and mortality as competing event. FINDINGS: Of 1576 included patients, 568 were SARS-CoV-2 pneumonia, 482 influenza pneumonia, and 526 no evidence of viral infection at ICU admission. VAP was associated with significantly higher risk for 28-day mortality in SARS-CoV-2 (adjusted HR 1.70 (95% CI 1.16-2.47), p = 0.006), and influenza groups (1.75 (1.03-3.02), p = 0.045), but not in the no viral infection group (1.07 (0.64-1.78), p = 0.79). VAP was associated with significantly longer duration of mechanical ventilation in the SARS-CoV-2 group, but not in the influenza or no viral infection groups. VAP was associated with significantly longer duration of ICU stay in the 3 study groups. No significant difference was found in heterogeneity of outcomes related to VAP between the 3 groups, suggesting that the impact of VAP on mortality was not different between study groups. INTERPRETATION: VAP was associated with significantly increased 28-day mortality rate in SARS-CoV-2 patients. However, SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, did not significantly modify the relationship between VAP and 28-day mortality. CLINICAL TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov, number NCT04359693.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNNseir, SaadMartin-Loeches, IgnacioPovoa, PedroMetzelard, MatthieuDu Cheyron, DamienLambiotte, FabienTamion, FabienneLabruyere, MarieMakris, DemosthenesBoulle Geronimi, ClairePinetonde Chambrun, MarcNyunga, MartinePouly, OlivierMégarbane, BrunoSaade, AnastasiaGomà, GemmaMagira, EleniLlitjos, Jean FrançoisTorres, AntoniIoannidou, IlianaPierre, AlexandreCoelho, LuisReignier, JeanGarot, DenisKreitmann, LouisBaudel, Jean LucVoiriot, GuillaumeContou, DamienBeurton, AlexandraAsfar, PierreBoyer, AlexandreThille, Arnaud W.Mekontso-Dessap, ArmandTsolaki, VassilikiVinsonneau, ChristopheFloch, Pierre EdouardLe Guennec, LoïcCeccato, AdrianArtigas, AntonioBouchereau, MathildeLabreuche, JulienDuhamel, AlainRouzé, Anahita2021-06-15T22:21:14Z2021-05-252021-05-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttp://hdl.handle.net/10362/119319eng1364-8535PURE: 31822732https://doi.org/10.1186/s13054-021-03588-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:01:50Zoai:run.unl.pt:10362/119319Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:01.727309Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients a planned ancillary analysis of the coVAPid cohort |
| title |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients |
| spellingShingle |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients Nseir, Saad COVID-19 Mortality Ventilator-associated pneumonia Critical Care and Intensive Care Medicine |
| title_short |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients |
| title_full |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients |
| title_fullStr |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients |
| title_full_unstemmed |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients |
| title_sort |
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients |
| author |
Nseir, Saad |
| author_facet |
Nseir, Saad Martin-Loeches, Ignacio Povoa, Pedro Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien Tamion, Fabienne Labruyere, Marie Makris, Demosthenes Boulle Geronimi, Claire Pinetonde Chambrun, Marc Nyunga, Martine Pouly, Olivier Mégarbane, Bruno Saade, Anastasia Gomà, Gemma Magira, Eleni Llitjos, Jean François Torres, Antoni Ioannidou, Iliana Pierre, Alexandre Coelho, Luis Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean Luc Voiriot, Guillaume Contou, Damien Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Thille, Arnaud W. Mekontso-Dessap, Armand Tsolaki, Vassiliki Vinsonneau, Christophe Floch, Pierre Edouard Le Guennec, Loïc Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde Labreuche, Julien Duhamel, Alain Rouzé, Anahita |
| author_role |
author |
| author2 |
Martin-Loeches, Ignacio Povoa, Pedro Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien Tamion, Fabienne Labruyere, Marie Makris, Demosthenes Boulle Geronimi, Claire Pinetonde Chambrun, Marc Nyunga, Martine Pouly, Olivier Mégarbane, Bruno Saade, Anastasia Gomà, Gemma Magira, Eleni Llitjos, Jean François Torres, Antoni Ioannidou, Iliana Pierre, Alexandre Coelho, Luis Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean Luc Voiriot, Guillaume Contou, Damien Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Thille, Arnaud W. Mekontso-Dessap, Armand Tsolaki, Vassiliki Vinsonneau, Christophe Floch, Pierre Edouard Le Guennec, Loïc Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde Labreuche, Julien Duhamel, Alain Rouzé, Anahita |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Nseir, Saad Martin-Loeches, Ignacio Povoa, Pedro Metzelard, Matthieu Du Cheyron, Damien Lambiotte, Fabien Tamion, Fabienne Labruyere, Marie Makris, Demosthenes Boulle Geronimi, Claire Pinetonde Chambrun, Marc Nyunga, Martine Pouly, Olivier Mégarbane, Bruno Saade, Anastasia Gomà, Gemma Magira, Eleni Llitjos, Jean François Torres, Antoni Ioannidou, Iliana Pierre, Alexandre Coelho, Luis Reignier, Jean Garot, Denis Kreitmann, Louis Baudel, Jean Luc Voiriot, Guillaume Contou, Damien Beurton, Alexandra Asfar, Pierre Boyer, Alexandre Thille, Arnaud W. Mekontso-Dessap, Armand Tsolaki, Vassiliki Vinsonneau, Christophe Floch, Pierre Edouard Le Guennec, Loïc Ceccato, Adrian Artigas, Antonio Bouchereau, Mathilde Labreuche, Julien Duhamel, Alain Rouzé, Anahita |
| dc.subject.por.fl_str_mv |
COVID-19 Mortality Ventilator-associated pneumonia Critical Care and Intensive Care Medicine |
| topic |
COVID-19 Mortality Ventilator-associated pneumonia Critical Care and Intensive Care Medicine |
| description |
Funding: This study was supported in part by a grant from the French government through the «Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). The funders of the study had no role in the study design, data collection, analysis, or interpreta tion, writing of the report, or decision to submit for publication. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-06-15T22:21:14Z 2021-05-25 2021-05-25T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/119319 |
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http://hdl.handle.net/10362/119319 |
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eng |
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eng |
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1364-8535 PURE: 31822732 https://doi.org/10.1186/s13054-021-03588-4 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1 application/pdf |
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