Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017

Detalhes bibliográficos
Autor(a) principal: Barradas, PF
Data de Publicação: 2020
Outros Autores: Neto, Z, Mateus, TL, Teodoro, AC, Duarte, L, Goncalves, H, Ferreira, P, Gärtner, F, Sousa, R, Amorim, I
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/143559
Resumo: Spotted fever group Rickettsia (SFGR) is one among the aetiologies that cause fever of unknown origin in Angola. Despite their occurrence, there is little information about its magnitude in this country either because it is misdiagnosed or due to the lack of diagnostic resources. For this purpose, eighty-seven selected malaria- A nd yellow fever-negative serum specimens collected between February 2016 and March 2017 as part of the National Laboratory of Febrile Syndromes, from patients with fever (=37.5°C) for at least 4 days and of unknown origin, were screened for Rickettsia antibodies through an immunofluorescence assay (IFA). Serological results were interpreted according to the 2017 guidelines for the detection of Rickettsia spp. Three seroreactive patients had detectable IgM antibodies to Rickettsia with an endpoint titre of 32 and IgG antibodies with endpoint titres of 128 and 256. These findings supported a diagnosis of Rickettsia exposure amongst these patients and highlight that rickettsioses may be among the cause of unknown febrile syndromes in Angola. Therefore, physicians must be aware of this reality and must include this vector-borne disease as part of aetiologies that should be considered and systematically tested in order to delineate appropriate strategies of diagnostic and control of Rickettsia in Angola.
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spelling Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017Spotted fever group Rickettsia (SFGR) is one among the aetiologies that cause fever of unknown origin in Angola. Despite their occurrence, there is little information about its magnitude in this country either because it is misdiagnosed or due to the lack of diagnostic resources. For this purpose, eighty-seven selected malaria- A nd yellow fever-negative serum specimens collected between February 2016 and March 2017 as part of the National Laboratory of Febrile Syndromes, from patients with fever (=37.5°C) for at least 4 days and of unknown origin, were screened for Rickettsia antibodies through an immunofluorescence assay (IFA). Serological results were interpreted according to the 2017 guidelines for the detection of Rickettsia spp. Three seroreactive patients had detectable IgM antibodies to Rickettsia with an endpoint titre of 32 and IgG antibodies with endpoint titres of 128 and 256. These findings supported a diagnosis of Rickettsia exposure amongst these patients and highlight that rickettsioses may be among the cause of unknown febrile syndromes in Angola. Therefore, physicians must be aware of this reality and must include this vector-borne disease as part of aetiologies that should be considered and systematically tested in order to delineate appropriate strategies of diagnostic and control of Rickettsia in Angola.Hindawi20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143559eng1687-708X10.1155/2020/4905783Barradas, PFNeto, ZMateus, TLTeodoro, ACDuarte, LGoncalves, HFerreira, PGärtner, FSousa, RAmorim, Iinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:31:02Zoai:repositorio-aberto.up.pt:10216/143559Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:02:56.540461Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
title Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
spellingShingle Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
Barradas, PF
title_short Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
title_full Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
title_fullStr Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
title_full_unstemmed Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
title_sort Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017
author Barradas, PF
author_facet Barradas, PF
Neto, Z
Mateus, TL
Teodoro, AC
Duarte, L
Goncalves, H
Ferreira, P
Gärtner, F
Sousa, R
Amorim, I
author_role author
author2 Neto, Z
Mateus, TL
Teodoro, AC
Duarte, L
Goncalves, H
Ferreira, P
Gärtner, F
Sousa, R
Amorim, I
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barradas, PF
Neto, Z
Mateus, TL
Teodoro, AC
Duarte, L
Goncalves, H
Ferreira, P
Gärtner, F
Sousa, R
Amorim, I
description Spotted fever group Rickettsia (SFGR) is one among the aetiologies that cause fever of unknown origin in Angola. Despite their occurrence, there is little information about its magnitude in this country either because it is misdiagnosed or due to the lack of diagnostic resources. For this purpose, eighty-seven selected malaria- A nd yellow fever-negative serum specimens collected between February 2016 and March 2017 as part of the National Laboratory of Febrile Syndromes, from patients with fever (=37.5°C) for at least 4 days and of unknown origin, were screened for Rickettsia antibodies through an immunofluorescence assay (IFA). Serological results were interpreted according to the 2017 guidelines for the detection of Rickettsia spp. Three seroreactive patients had detectable IgM antibodies to Rickettsia with an endpoint titre of 32 and IgG antibodies with endpoint titres of 128 and 256. These findings supported a diagnosis of Rickettsia exposure amongst these patients and highlight that rickettsioses may be among the cause of unknown febrile syndromes in Angola. Therefore, physicians must be aware of this reality and must include this vector-borne disease as part of aetiologies that should be considered and systematically tested in order to delineate appropriate strategies of diagnostic and control of Rickettsia in Angola.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
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