Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/3410 |
Resumo: | Several flaviviruses are important pathogens for humans and animals (Dengue viruses, Japanese encephalitis virus, Yellow-fever virus, Tick-borne encephalitis virus, West Nile virus). In recent years, numerous novel and related flaviviruses without known pathogenic capacity have been isolated worldwide in the natural mosquito population. However, phylogenetic studies have shown that genomic sequences of these viruses diverge from other flaviviruses. Moreover, these viruses seem to be exclusive of insects (they do not seem to grow on vertebrate cell lines), and were already defined as mosquito-only flaviviruses or insect-specific flaviviruses. At least eleven of these viruses were isolated worldwide, and sequences ascribable to other eleven putative viruses were detected in several mosquito species. A large part of the cycle of these viruses is not well known, and their persistence in the environment is poorly understood. These viruses are detected in a wide variety of distinct mosquito species and also in sandflies and chironomids worldwide; a single virus, or the genetic material ascribable to a virus, was detected in several mosquito species in different countries, often in different continents. Furthermore, some of these viruses are carried by invasive mosquitoes, and do not seem to have a depressive action on their fitness. The global distribution and the continuous detection of new viruses in this group point out the likely underestimation of their number, and raise interesting issues about their possible interactions with the pathogenic flaviviruses, and their influence on the bionomics of arthropod hosts. Some enigmatic features, as their integration in the mosquito genome, the recognition of their genetic material in DNA forms in field-collected mosquitoes, or the detection of the same virus in both mosquitoes and sandflies, indicate that the cycle of these viruses has unknown characteristics that could be of use to reach a deeper understanding of the cycle of related pathogenic flaviviruses. |
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Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insectsInfecções Sistémicas e ZoonosesInsect-specific FlavivirusMosquito-only FlavivirusMosquitoSandflyCell Fusing Agent VirusKamiti River VirusCulex FlavivirusAedes FlavivirusQuang Binh VirusOchlerotatus Caspius FlavivirusSeveral flaviviruses are important pathogens for humans and animals (Dengue viruses, Japanese encephalitis virus, Yellow-fever virus, Tick-borne encephalitis virus, West Nile virus). In recent years, numerous novel and related flaviviruses without known pathogenic capacity have been isolated worldwide in the natural mosquito population. However, phylogenetic studies have shown that genomic sequences of these viruses diverge from other flaviviruses. Moreover, these viruses seem to be exclusive of insects (they do not seem to grow on vertebrate cell lines), and were already defined as mosquito-only flaviviruses or insect-specific flaviviruses. At least eleven of these viruses were isolated worldwide, and sequences ascribable to other eleven putative viruses were detected in several mosquito species. A large part of the cycle of these viruses is not well known, and their persistence in the environment is poorly understood. These viruses are detected in a wide variety of distinct mosquito species and also in sandflies and chironomids worldwide; a single virus, or the genetic material ascribable to a virus, was detected in several mosquito species in different countries, often in different continents. Furthermore, some of these viruses are carried by invasive mosquitoes, and do not seem to have a depressive action on their fitness. The global distribution and the continuous detection of new viruses in this group point out the likely underestimation of their number, and raise interesting issues about their possible interactions with the pathogenic flaviviruses, and their influence on the bionomics of arthropod hosts. Some enigmatic features, as their integration in the mosquito genome, the recognition of their genetic material in DNA forms in field-collected mosquitoes, or the detection of the same virus in both mosquitoes and sandflies, indicate that the cycle of these viruses has unknown characteristics that could be of use to reach a deeper understanding of the cycle of related pathogenic flaviviruses.In Italy mosquito collections were performed in the frame of the Regional project on insect borne diseases (COMM07001). In Portugal part of the mosquito collections were performed in a collaboration program with the Algarve Regional Health Administration and the research work was funded by the PTDC/SAU-SAP/119199/2010 FCT project and partially supported and by centre grant (to BioISI, Centre Reference: UID/MULTI/04046/2013) from FCT/MCTES/PIDDAC, Portugal.ElsevierRepositório Científico do Instituto Nacional de SaúdeCalzolari, M.Zé-Zé, LíbiaVásquez, A.Seco, M.P.S.Amaro, FátimaDottori, M.2018-01-01T01:30:10Z2015-07-312015-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3410engInfect Genet Evol. 2016 Jun;40:381-8. doi: 10.1016/j.meegid.2015.07.032. Epub 2015 Jul 31.1567-134810.1016/j.meegid.2015.07.032info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:42Zoai:repositorio.insa.pt:10400.18/3410Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:09.860266Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
title |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
spellingShingle |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects Calzolari, M. Infecções Sistémicas e Zoonoses Insect-specific Flavivirus Mosquito-only Flavivirus Mosquito Sandfly Cell Fusing Agent Virus Kamiti River Virus Culex Flavivirus Aedes Flavivirus Quang Binh Virus Ochlerotatus Caspius Flavivirus |
title_short |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
title_full |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
title_fullStr |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
title_full_unstemmed |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
title_sort |
Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects |
author |
Calzolari, M. |
author_facet |
Calzolari, M. Zé-Zé, Líbia Vásquez, A. Seco, M.P.S. Amaro, Fátima Dottori, M. |
author_role |
author |
author2 |
Zé-Zé, Líbia Vásquez, A. Seco, M.P.S. Amaro, Fátima Dottori, M. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Calzolari, M. Zé-Zé, Líbia Vásquez, A. Seco, M.P.S. Amaro, Fátima Dottori, M. |
dc.subject.por.fl_str_mv |
Infecções Sistémicas e Zoonoses Insect-specific Flavivirus Mosquito-only Flavivirus Mosquito Sandfly Cell Fusing Agent Virus Kamiti River Virus Culex Flavivirus Aedes Flavivirus Quang Binh Virus Ochlerotatus Caspius Flavivirus |
topic |
Infecções Sistémicas e Zoonoses Insect-specific Flavivirus Mosquito-only Flavivirus Mosquito Sandfly Cell Fusing Agent Virus Kamiti River Virus Culex Flavivirus Aedes Flavivirus Quang Binh Virus Ochlerotatus Caspius Flavivirus |
description |
Several flaviviruses are important pathogens for humans and animals (Dengue viruses, Japanese encephalitis virus, Yellow-fever virus, Tick-borne encephalitis virus, West Nile virus). In recent years, numerous novel and related flaviviruses without known pathogenic capacity have been isolated worldwide in the natural mosquito population. However, phylogenetic studies have shown that genomic sequences of these viruses diverge from other flaviviruses. Moreover, these viruses seem to be exclusive of insects (they do not seem to grow on vertebrate cell lines), and were already defined as mosquito-only flaviviruses or insect-specific flaviviruses. At least eleven of these viruses were isolated worldwide, and sequences ascribable to other eleven putative viruses were detected in several mosquito species. A large part of the cycle of these viruses is not well known, and their persistence in the environment is poorly understood. These viruses are detected in a wide variety of distinct mosquito species and also in sandflies and chironomids worldwide; a single virus, or the genetic material ascribable to a virus, was detected in several mosquito species in different countries, often in different continents. Furthermore, some of these viruses are carried by invasive mosquitoes, and do not seem to have a depressive action on their fitness. The global distribution and the continuous detection of new viruses in this group point out the likely underestimation of their number, and raise interesting issues about their possible interactions with the pathogenic flaviviruses, and their influence on the bionomics of arthropod hosts. Some enigmatic features, as their integration in the mosquito genome, the recognition of their genetic material in DNA forms in field-collected mosquitoes, or the detection of the same virus in both mosquitoes and sandflies, indicate that the cycle of these viruses has unknown characteristics that could be of use to reach a deeper understanding of the cycle of related pathogenic flaviviruses. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-31 2015-07-31T00:00:00Z 2018-01-01T01:30:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/3410 |
url |
http://hdl.handle.net/10400.18/3410 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Infect Genet Evol. 2016 Jun;40:381-8. doi: 10.1016/j.meegid.2015.07.032. Epub 2015 Jul 31. 1567-1348 10.1016/j.meegid.2015.07.032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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