Anti-MuSK-positive myasthenia gravis diagnosed during pregnancy: New challenges for an old disease

• Autor(a) principal: Neves, AR
• Data de Publicação: 2015
• Outros Autores: Monteiro, P, Matos, A, Santos-Silva, I
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.4/1786
• topic: Miastenia Gravis; Complicações na Gravidez; Recém-Nascido; Anticorpos; Receptores Proteína Tirosina Quinases

Myasthenia gravis is an autoimmune disorder affecting predominantly women in their reproductive age. The course of the disease during pregnancy is unpredictable, although it is more difficult to manage earlier in the gestation. Myasthenia gravis with antibodies against the muscle-specific receptor tyrosine kinase (anti-MuSK) has been described as a subtype of disease with more localised clinical features and a poorer response to treatment than acetylcholine receptor antibody (anti-AChR)-positive patients. Few cases have been reported in pregnant women, with deliveries being performed mainly by caesarean section. We report a successful case of vaginal delivery and describe our experience providing the first review of the management of this subtype of disease during pregnancy.