Neuroprotective activity of Hypericum perforatum and its major components
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/51280 |
Resumo: | Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. Johns wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H. perforatum, as for its chemistry, pharmacological activities, drug interactions and adverse reactions and gather scattered information about its neuroprotective abilities. As for this, it has been demonstrated that H. perforatum extracts and several of its major molecular components have the ability to protect against toxic insults, either directly, through neuroprotective mechanisms, or indirectly, through is antioxidant properties. H. perforatum has therefore the potential to become an effective neuroprotective therapeutic agent, despite further studies that need to be carried out. |
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Neuroprotective activity of Hypericum perforatum and its major componentsHypericum perforatumextractscompoundsneuroprotectionantioxidant activityScience & TechnologyHypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. Johns wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H. perforatum, as for its chemistry, pharmacological activities, drug interactions and adverse reactions and gather scattered information about its neuroprotective abilities. As for this, it has been demonstrated that H. perforatum extracts and several of its major molecular components have the ability to protect against toxic insults, either directly, through neuroprotective mechanisms, or indirectly, through is antioxidant properties. H. perforatum has therefore the potential to become an effective neuroprotective therapeutic agent, despite further studies that need to be carried out.This work was supported by Fundacao para a Ciencia e Tecnologia (FCT), projects PTDC/AGR-ALI/105169/2008, PEst-OE/AGR/UI4033/2014. AO was supported by Escola Superior de Tecnologia da Saude do Porto and Instituto Politecnico do Porto (Programa de Formacao Avancada de Docentes).info:eu-repo/semantics/publishedVersionFrontiers MediaUniversidade do MinhoOliveira, Ana I.Pinho, ClaudiaSarmento, BrunoDias, Alberto Carlos Pires20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/51280eng1664-462X10.3389/fpls.2016.01004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:28:45Zoai:repositorium.sdum.uminho.pt:1822/51280Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:23:36.832924Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neuroprotective activity of Hypericum perforatum and its major components |
title |
Neuroprotective activity of Hypericum perforatum and its major components |
spellingShingle |
Neuroprotective activity of Hypericum perforatum and its major components Oliveira, Ana I. Hypericum perforatum extracts compounds neuroprotection antioxidant activity Science & Technology |
title_short |
Neuroprotective activity of Hypericum perforatum and its major components |
title_full |
Neuroprotective activity of Hypericum perforatum and its major components |
title_fullStr |
Neuroprotective activity of Hypericum perforatum and its major components |
title_full_unstemmed |
Neuroprotective activity of Hypericum perforatum and its major components |
title_sort |
Neuroprotective activity of Hypericum perforatum and its major components |
author |
Oliveira, Ana I. |
author_facet |
Oliveira, Ana I. Pinho, Claudia Sarmento, Bruno Dias, Alberto Carlos Pires |
author_role |
author |
author2 |
Pinho, Claudia Sarmento, Bruno Dias, Alberto Carlos Pires |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Oliveira, Ana I. Pinho, Claudia Sarmento, Bruno Dias, Alberto Carlos Pires |
dc.subject.por.fl_str_mv |
Hypericum perforatum extracts compounds neuroprotection antioxidant activity Science & Technology |
topic |
Hypericum perforatum extracts compounds neuroprotection antioxidant activity Science & Technology |
description |
Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. Johns wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H. perforatum, as for its chemistry, pharmacological activities, drug interactions and adverse reactions and gather scattered information about its neuroprotective abilities. As for this, it has been demonstrated that H. perforatum extracts and several of its major molecular components have the ability to protect against toxic insults, either directly, through neuroprotective mechanisms, or indirectly, through is antioxidant properties. H. perforatum has therefore the potential to become an effective neuroprotective therapeutic agent, despite further studies that need to be carried out. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/51280 |
url |
http://hdl.handle.net/1822/51280 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-462X 10.3389/fpls.2016.01004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132711666843648 |