Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/43980 https://doi.org/10.1007/s00414-016-1321-8 |
Resumo: | Gamma-hydroxybutyric acid (GHB) is an endogenous compound which has a story of clinical use and illicit abuse since the 1960’s. The possibility to use a multi-sample approach of GHB evaluation, including whole blood and hair, to better characterize a forensic toxicology case and evaluate a possible causal association with the death, is an exciting up-to-date issue. In addition, its post-mortem behaviour, namely regarding degradation and metabolism, has been increasingly investigated as a putative biomarker for post-mortem interval (PMI) estimation. Thus, In order to contribute to clarify this specific aspect, whole blood and hair post-mortem GHB levels were evaluated in thirty two real cases with previous information on death and autopsy data. The results obtained suggest that the PMI (until 5 days between death and sampling) influences GHB whole blood concentration, but not GHB levels in hair samples. No differences were encountered for the other parameters evaluated, including age, gender, cause of death and presence or absence of substances. This study brings new insights regarding the usefulness of GHB levels in forensic toxicology, which might be further strengthened with larger, but comparable, studies from other laboratories and institutions in the context of legal medicine. |
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Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem intervalGamma-hydroxybutyric acid (GHB)Post-mortem intervalEndogenous valuesHair and whole blood samplesGamma-hydroxybutyric acid (GHB) is an endogenous compound which has a story of clinical use and illicit abuse since the 1960’s. The possibility to use a multi-sample approach of GHB evaluation, including whole blood and hair, to better characterize a forensic toxicology case and evaluate a possible causal association with the death, is an exciting up-to-date issue. In addition, its post-mortem behaviour, namely regarding degradation and metabolism, has been increasingly investigated as a putative biomarker for post-mortem interval (PMI) estimation. Thus, In order to contribute to clarify this specific aspect, whole blood and hair post-mortem GHB levels were evaluated in thirty two real cases with previous information on death and autopsy data. The results obtained suggest that the PMI (until 5 days between death and sampling) influences GHB whole blood concentration, but not GHB levels in hair samples. No differences were encountered for the other parameters evaluated, including age, gender, cause of death and presence or absence of substances. This study brings new insights regarding the usefulness of GHB levels in forensic toxicology, which might be further strengthened with larger, but comparable, studies from other laboratories and institutions in the context of legal medicine.info:eu-repo/semantics/acceptedVersionSpringer Link2023-02-28T16:42:47Z2023-02-282016-02-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10400.26/43980http://hdl.handle.net/10400.26/43980https://doi.org/10.1007/s00414-016-1321-8engCastro, A.L., Tarelho, S., Dias, M. et al. Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval. Int J Legal Med 130, 959–965 (2016).https://link.springer.com/article/10.1007/s00414-016-1321-8Castro, André LoboTarelho, SóniaDias, MárioReis, FlávioTeixeira, Helena M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-03T04:22:26Zoai:comum.rcaap.pt:10400.26/43980Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:07:48.549445Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
title |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
spellingShingle |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval Castro, André Lobo Gamma-hydroxybutyric acid (GHB) Post-mortem interval Endogenous values Hair and whole blood samples |
title_short |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
title_full |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
title_fullStr |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
title_full_unstemmed |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
title_sort |
Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval |
author |
Castro, André Lobo |
author_facet |
Castro, André Lobo Tarelho, Sónia Dias, Mário Reis, Flávio Teixeira, Helena M. |
author_role |
author |
author2 |
Tarelho, Sónia Dias, Mário Reis, Flávio Teixeira, Helena M. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Castro, André Lobo Tarelho, Sónia Dias, Mário Reis, Flávio Teixeira, Helena M. |
dc.subject.por.fl_str_mv |
Gamma-hydroxybutyric acid (GHB) Post-mortem interval Endogenous values Hair and whole blood samples |
topic |
Gamma-hydroxybutyric acid (GHB) Post-mortem interval Endogenous values Hair and whole blood samples |
description |
Gamma-hydroxybutyric acid (GHB) is an endogenous compound which has a story of clinical use and illicit abuse since the 1960’s. The possibility to use a multi-sample approach of GHB evaluation, including whole blood and hair, to better characterize a forensic toxicology case and evaluate a possible causal association with the death, is an exciting up-to-date issue. In addition, its post-mortem behaviour, namely regarding degradation and metabolism, has been increasingly investigated as a putative biomarker for post-mortem interval (PMI) estimation. Thus, In order to contribute to clarify this specific aspect, whole blood and hair post-mortem GHB levels were evaluated in thirty two real cases with previous information on death and autopsy data. The results obtained suggest that the PMI (until 5 days between death and sampling) influences GHB whole blood concentration, but not GHB levels in hair samples. No differences were encountered for the other parameters evaluated, including age, gender, cause of death and presence or absence of substances. This study brings new insights regarding the usefulness of GHB levels in forensic toxicology, which might be further strengthened with larger, but comparable, studies from other laboratories and institutions in the context of legal medicine. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-04T00:00:00Z 2023-02-28T16:42:47Z 2023-02-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/43980 http://hdl.handle.net/10400.26/43980 https://doi.org/10.1007/s00414-016-1321-8 |
url |
http://hdl.handle.net/10400.26/43980 https://doi.org/10.1007/s00414-016-1321-8 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Castro, A.L., Tarelho, S., Dias, M. et al. Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval. Int J Legal Med 130, 959–965 (2016). https://link.springer.com/article/10.1007/s00414-016-1321-8 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Link |
publisher.none.fl_str_mv |
Springer Link |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137166956167168 |