Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?

Detalhes bibliográficos
Autor(a) principal: Meira e Cruz, Miguel
Data de Publicação: 2020
Outros Autores: Rocha, Isabel, Bruni, Oliviero
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/42503
Resumo: Copyright © Ordem dos Médicos 2020
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spelling Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?Risco cardiometabólico na infância : pode a bilirrubina atuar como mediador associado ao relógio circadiano via disfunção autonómica?Copyright © Ordem dos Médicos 2020The interesting paper from Yu and colleagues on the association of neonatal serum bilirubin and childhood hypertension recently published in Plos One, flagged up a plausible role of bilirubin as a mediator of hypertension in later life. This is a highly important topic since hypertension, a main cause of cardiometabolic associated morbidity and mortality, may affect 2% to 4% of children. Bilirubin is a toxic endproduct of heme catabolism in the body, commonly seen in newborns and causing jaundice. It is detoxified mainly in the liver by means of several steps involving circadian regulated enzymatic processes. A balanced autonomic output to the liver is crucial for maintenance of the circadian rhythmicity that ensures the normal function of liver metabolic enzymes and glucose level.Ordem dos MédicosRepositório da Universidade de LisboaMeira e Cruz, MiguelRocha, IsabelBruni, Oliviero2020-03-19T12:05:12Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/42503engActa Med Port 2020 Jan;33(1):76-801646-075810.20344/amp.12786info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:42:26Zoai:repositorio.ul.pt:10451/42503Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:55:29.223563Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
Risco cardiometabólico na infância : pode a bilirrubina atuar como mediador associado ao relógio circadiano via disfunção autonómica?
title Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
spellingShingle Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
Meira e Cruz, Miguel
title_short Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
title_full Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
title_fullStr Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
title_full_unstemmed Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
title_sort Cardiometabolic risk in childhood : could bilirubin act as a circadian clock-related mediator via autonomic dysfunction?
author Meira e Cruz, Miguel
author_facet Meira e Cruz, Miguel
Rocha, Isabel
Bruni, Oliviero
author_role author
author2 Rocha, Isabel
Bruni, Oliviero
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Meira e Cruz, Miguel
Rocha, Isabel
Bruni, Oliviero
description Copyright © Ordem dos Médicos 2020
publishDate 2020
dc.date.none.fl_str_mv 2020-03-19T12:05:12Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/42503
url http://hdl.handle.net/10451/42503
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Med Port 2020 Jan;33(1):76-80
1646-0758
10.20344/amp.12786
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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